Utilization of HbA1c in Screening Living Kidney Donors With Prediabetes

Joon Chae Na, Min Gee Yoon, Hyung Ho Lee, Young Eun Yoon, Deok Gie Kim, Kyu Ha Huh, Yu Seun Kim, Woong Kyu Han

Research output: Contribution to journalArticle

Abstract

Objectives: To study the outcome of living kidney donors with prediabetes and to evaluate the utilization of baseline HbA1c to identify donors at high risk for developing diabetes during the postdonation follow-up period. Patients and methods: Living kidney donors with prospectively collected preoperative fasting glucose and HbA1c results were included in the study. Donors were categorized to the high-risk group when both results were in the prediabetic range, the low-risk group when only 1 result was in the prediabetic range, and the control group when both results were normal. Results: Ninety-three donors were followed for 75.9 ± 23.3 months. A higher proportion of donors in the high-risk group progressed to diabetes compared with donors in the low-risk and control groups (31.3% vs 6.5% vs 0.0%, respectively; P < .001). Donors with prediabetes were not at a higher risk for new-onset hypertension (4.4% vs 10.0% vs 7.7%, in control, low-risk, and high-risk groups, respectively; P = .519) or microproteinuria (7.3% vs 10.3% vs 0.0%, in control, low-risk, and high-risk groups, respectively; P = .478) and exhibited equivalent postdonation renal function compared with donors with normal glucose metabolism. Conclusions: HbA1c can identify donors with prediabetes who are at risk for progression to diabetes. Our results indicate that carefully accepted donors with prediabetes are not at increased risk of renal function deterioration in the immediate postdonation period.

Original languageEnglish
Pages (from-to)2527-2532
Number of pages6
JournalTransplantation Proceedings
Volume51
Issue number8
DOIs
Publication statusPublished - 2019 Oct

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Prediabetic State
Living Donors
Kidney
Tissue Donors
Glucose
Control Groups
Fasting

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Na, Joon Chae ; Yoon, Min Gee ; Lee, Hyung Ho ; Yoon, Young Eun ; Kim, Deok Gie ; Huh, Kyu Ha ; Kim, Yu Seun ; Han, Woong Kyu. / Utilization of HbA1c in Screening Living Kidney Donors With Prediabetes. In: Transplantation Proceedings. 2019 ; Vol. 51, No. 8. pp. 2527-2532.
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abstract = "Objectives: To study the outcome of living kidney donors with prediabetes and to evaluate the utilization of baseline HbA1c to identify donors at high risk for developing diabetes during the postdonation follow-up period. Patients and methods: Living kidney donors with prospectively collected preoperative fasting glucose and HbA1c results were included in the study. Donors were categorized to the high-risk group when both results were in the prediabetic range, the low-risk group when only 1 result was in the prediabetic range, and the control group when both results were normal. Results: Ninety-three donors were followed for 75.9 ± 23.3 months. A higher proportion of donors in the high-risk group progressed to diabetes compared with donors in the low-risk and control groups (31.3{\%} vs 6.5{\%} vs 0.0{\%}, respectively; P < .001). Donors with prediabetes were not at a higher risk for new-onset hypertension (4.4{\%} vs 10.0{\%} vs 7.7{\%}, in control, low-risk, and high-risk groups, respectively; P = .519) or microproteinuria (7.3{\%} vs 10.3{\%} vs 0.0{\%}, in control, low-risk, and high-risk groups, respectively; P = .478) and exhibited equivalent postdonation renal function compared with donors with normal glucose metabolism. Conclusions: HbA1c can identify donors with prediabetes who are at risk for progression to diabetes. Our results indicate that carefully accepted donors with prediabetes are not at increased risk of renal function deterioration in the immediate postdonation period.",
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Utilization of HbA1c in Screening Living Kidney Donors With Prediabetes. / Na, Joon Chae; Yoon, Min Gee; Lee, Hyung Ho; Yoon, Young Eun; Kim, Deok Gie; Huh, Kyu Ha; Kim, Yu Seun; Han, Woong Kyu.

In: Transplantation Proceedings, Vol. 51, No. 8, 10.2019, p. 2527-2532.

Research output: Contribution to journalArticle

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AU - Na, Joon Chae

AU - Yoon, Min Gee

AU - Lee, Hyung Ho

AU - Yoon, Young Eun

AU - Kim, Deok Gie

AU - Huh, Kyu Ha

AU - Kim, Yu Seun

AU - Han, Woong Kyu

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N2 - Objectives: To study the outcome of living kidney donors with prediabetes and to evaluate the utilization of baseline HbA1c to identify donors at high risk for developing diabetes during the postdonation follow-up period. Patients and methods: Living kidney donors with prospectively collected preoperative fasting glucose and HbA1c results were included in the study. Donors were categorized to the high-risk group when both results were in the prediabetic range, the low-risk group when only 1 result was in the prediabetic range, and the control group when both results were normal. Results: Ninety-three donors were followed for 75.9 ± 23.3 months. A higher proportion of donors in the high-risk group progressed to diabetes compared with donors in the low-risk and control groups (31.3% vs 6.5% vs 0.0%, respectively; P < .001). Donors with prediabetes were not at a higher risk for new-onset hypertension (4.4% vs 10.0% vs 7.7%, in control, low-risk, and high-risk groups, respectively; P = .519) or microproteinuria (7.3% vs 10.3% vs 0.0%, in control, low-risk, and high-risk groups, respectively; P = .478) and exhibited equivalent postdonation renal function compared with donors with normal glucose metabolism. Conclusions: HbA1c can identify donors with prediabetes who are at risk for progression to diabetes. Our results indicate that carefully accepted donors with prediabetes are not at increased risk of renal function deterioration in the immediate postdonation period.

AB - Objectives: To study the outcome of living kidney donors with prediabetes and to evaluate the utilization of baseline HbA1c to identify donors at high risk for developing diabetes during the postdonation follow-up period. Patients and methods: Living kidney donors with prospectively collected preoperative fasting glucose and HbA1c results were included in the study. Donors were categorized to the high-risk group when both results were in the prediabetic range, the low-risk group when only 1 result was in the prediabetic range, and the control group when both results were normal. Results: Ninety-three donors were followed for 75.9 ± 23.3 months. A higher proportion of donors in the high-risk group progressed to diabetes compared with donors in the low-risk and control groups (31.3% vs 6.5% vs 0.0%, respectively; P < .001). Donors with prediabetes were not at a higher risk for new-onset hypertension (4.4% vs 10.0% vs 7.7%, in control, low-risk, and high-risk groups, respectively; P = .519) or microproteinuria (7.3% vs 10.3% vs 0.0%, in control, low-risk, and high-risk groups, respectively; P = .478) and exhibited equivalent postdonation renal function compared with donors with normal glucose metabolism. Conclusions: HbA1c can identify donors with prediabetes who are at risk for progression to diabetes. Our results indicate that carefully accepted donors with prediabetes are not at increased risk of renal function deterioration in the immediate postdonation period.

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