Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible

Young Sun Hwang, Sang Sun Han, Ki Rim Kim, Ye Jin Lee, Sun Kyung Lee, Kwang Kyun Park, Won Yoon Chung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Metastatic breast carcinoma has a great tendency to spread to the mandible. It is concomitantly associated with bone destruction, food intake disorder, and a poorer prognosis. Appropriate animal models need to be developed for a better understanding of the mechanisms underlying the metastatic process of breast cancer cells to mandible and to test the effects of potential lead compounds. Here, we assessed the metastasis model of intracardiac injection using luciferase-transfected metastatic breast cancer cells (MDAMB- 231Luc+) by determining the incidences of metastasis, mCT images, and histopathological results. A high bioluminescence signal mainly detected mandibular lesions with less frequent distal femora and proximal tibiae lesions. Extensive mandibular bone destruction occurred in nude mice grafted with metastatic breast cancer cells. This type of animal model might be a useful tool in assessing therapeutic implications and the efficacy of anti-cancer drugs for osteolytic cancers.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalJournal of Applied Oral Science
Volume23
Issue number1
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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