Validation of a quantitative 12-multigene expression assay (Oncotype DX® colon cancer assay) in Korean patients with stage II colon cancer: Implication of ethnic differences contributing to differences in gene expression

Duck Hyoun Jeong, Woo Ram Kim, Byung Soh Min, Young Wan Kim, Mi Kyung Song, Nam Kyu Kim

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5 Citations (Scopus)

Abstract

Purpose: To evaluate the Recurrence Score® of the quantitative 12-multigene expression assay and to determine risk groups based on the continuous Recurrence Score® in Korean patients. Method: A total of 95 patients with pathological T3N0 tumors and mismatch repair-proficient tumors were enrolled. The Recurrence Score® was used to classify risk groups (low risk,,30; intermediate risk, 30–40; high risk, ≥41). Results: Fifty-four patients (56.8%) were aged over 70 years. There were 49 men (51.6%) and 56 cases of right-sided colon cancer (58.9%). Eight cases (8.4%) had well-differentiated tumors, and 86 cases (90.5%) showed moderate differentiation. Only one case (1.1%) had a poorly differentiated tumor. Three patients (3.2%) had lymphovascular invasion. Sixty-one patients were identified as low risk (64.2%) and 34 patients as intermediate risk (35.8%). There were no high-risk patients. Although not significant, the 3-year recurrence risk increased with the Recurrence Score®. Conclusion: Distribution patterns of risk groups based on the Recurrence Score®, particularly the absence of a high-risk group, were different from the prior validation studies. These findings suggest that ethnic differences between Koreans and Western patients are potential contributing factors for different gene expressions in the quantitative 12-multigene expression assay.

Original languageEnglish
Pages (from-to)3817-3825
Number of pages9
JournalOncoTargets and Therapy
Volume8
DOIs
Publication statusPublished - 2015 Dec 17

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Colonic Neoplasms
Gene Expression
Recurrence
Neoplasms
DNA Mismatch Repair
Validation Studies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology (medical)

Cite this

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title = "Validation of a quantitative 12-multigene expression assay (Oncotype DX{\circledR} colon cancer assay) in Korean patients with stage II colon cancer: Implication of ethnic differences contributing to differences in gene expression",
abstract = "Purpose: To evaluate the Recurrence Score{\circledR} of the quantitative 12-multigene expression assay and to determine risk groups based on the continuous Recurrence Score{\circledR} in Korean patients. Method: A total of 95 patients with pathological T3N0 tumors and mismatch repair-proficient tumors were enrolled. The Recurrence Score{\circledR} was used to classify risk groups (low risk,,30; intermediate risk, 30–40; high risk, ≥41). Results: Fifty-four patients (56.8{\%}) were aged over 70 years. There were 49 men (51.6{\%}) and 56 cases of right-sided colon cancer (58.9{\%}). Eight cases (8.4{\%}) had well-differentiated tumors, and 86 cases (90.5{\%}) showed moderate differentiation. Only one case (1.1{\%}) had a poorly differentiated tumor. Three patients (3.2{\%}) had lymphovascular invasion. Sixty-one patients were identified as low risk (64.2{\%}) and 34 patients as intermediate risk (35.8{\%}). There were no high-risk patients. Although not significant, the 3-year recurrence risk increased with the Recurrence Score{\circledR}. Conclusion: Distribution patterns of risk groups based on the Recurrence Score{\circledR}, particularly the absence of a high-risk group, were different from the prior validation studies. These findings suggest that ethnic differences between Koreans and Western patients are potential contributing factors for different gene expressions in the quantitative 12-multigene expression assay.",
author = "Jeong, {Duck Hyoun} and Kim, {Woo Ram} and Min, {Byung Soh} and Kim, {Young Wan} and Song, {Mi Kyung} and Kim, {Nam Kyu}",
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T1 - Validation of a quantitative 12-multigene expression assay (Oncotype DX® colon cancer assay) in Korean patients with stage II colon cancer

T2 - Implication of ethnic differences contributing to differences in gene expression

AU - Jeong, Duck Hyoun

AU - Kim, Woo Ram

AU - Min, Byung Soh

AU - Kim, Young Wan

AU - Song, Mi Kyung

AU - Kim, Nam Kyu

PY - 2015/12/17

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N2 - Purpose: To evaluate the Recurrence Score® of the quantitative 12-multigene expression assay and to determine risk groups based on the continuous Recurrence Score® in Korean patients. Method: A total of 95 patients with pathological T3N0 tumors and mismatch repair-proficient tumors were enrolled. The Recurrence Score® was used to classify risk groups (low risk,,30; intermediate risk, 30–40; high risk, ≥41). Results: Fifty-four patients (56.8%) were aged over 70 years. There were 49 men (51.6%) and 56 cases of right-sided colon cancer (58.9%). Eight cases (8.4%) had well-differentiated tumors, and 86 cases (90.5%) showed moderate differentiation. Only one case (1.1%) had a poorly differentiated tumor. Three patients (3.2%) had lymphovascular invasion. Sixty-one patients were identified as low risk (64.2%) and 34 patients as intermediate risk (35.8%). There were no high-risk patients. Although not significant, the 3-year recurrence risk increased with the Recurrence Score®. Conclusion: Distribution patterns of risk groups based on the Recurrence Score®, particularly the absence of a high-risk group, were different from the prior validation studies. These findings suggest that ethnic differences between Koreans and Western patients are potential contributing factors for different gene expressions in the quantitative 12-multigene expression assay.

AB - Purpose: To evaluate the Recurrence Score® of the quantitative 12-multigene expression assay and to determine risk groups based on the continuous Recurrence Score® in Korean patients. Method: A total of 95 patients with pathological T3N0 tumors and mismatch repair-proficient tumors were enrolled. The Recurrence Score® was used to classify risk groups (low risk,,30; intermediate risk, 30–40; high risk, ≥41). Results: Fifty-four patients (56.8%) were aged over 70 years. There were 49 men (51.6%) and 56 cases of right-sided colon cancer (58.9%). Eight cases (8.4%) had well-differentiated tumors, and 86 cases (90.5%) showed moderate differentiation. Only one case (1.1%) had a poorly differentiated tumor. Three patients (3.2%) had lymphovascular invasion. Sixty-one patients were identified as low risk (64.2%) and 34 patients as intermediate risk (35.8%). There were no high-risk patients. Although not significant, the 3-year recurrence risk increased with the Recurrence Score®. Conclusion: Distribution patterns of risk groups based on the Recurrence Score®, particularly the absence of a high-risk group, were different from the prior validation studies. These findings suggest that ethnic differences between Koreans and Western patients are potential contributing factors for different gene expressions in the quantitative 12-multigene expression assay.

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