Validation of pulse pressure variation and corrected flow time as predictors of fluid responsiveness in patients in the prone position

S. Y. Yang, J. K. Shim, Y. Song, S. J. Seo, Y. L. Kwak

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Abstract

BackgroundThe aim of this prospective trial was to investigate the ability of pulse pressure variation (PPV) and corrected flow time (FTc) to predict fluid responsiveness in the prone position.MethodsForty-four patients undergoing lumbar spine surgery in the prone position on a Wilson frame were prospectively studied. PPV and FTc were measured before and after a colloid bolus (6 ml kg-1) both in the supine and in the prone positions. Fluid responsiveness was defined as an increase in the stroke volume index of ≥10% as measured by oesophageal Doppler.ResultsIn the supine position, 26 patients were responders and the areas under the curve (AUC) of the receiver-operator characteristic (ROC) curves of PPV and FTc were 0.935 [95% confidence interval (CI): 0.870-0.999, P<0.001] and 0.822 (95% CI: 0.682-0.961, P<0.001), respectively. The optimal cut-off PPV and FTc values were 15% (sensitivity 73%, specificity 94%) and 358 ms (sensitivity 88%, specificity 78%), respectively. In the prone position, 34 patients were responders and the AUCs of PPV and FTc were 0.969 (95% CI: 0.912-1.000, P<0.001) and 0.846 (95% CI: 0.706-0.985, P=0.001), respectively. The optimal cut-off PPV and FTc values were 14% (sensitivity 97%, specificity 90%) and 331 ms (sensitivity 77%, specificity 90%), respectively.ConclusionsWhile the predictability of PPV was significantly higher than that of FTc in the prone position, both variables showed high predictability and remained as useful indices for guiding fluid therapy in prone patients with minimal alterations in their optimal cut-off values to predict fluid responsiveness.

Original languageEnglish
Pages (from-to)713-720
Number of pages8
JournalBritish Journal of Anaesthesia
Volume110
Issue number5
DOIs
Publication statusPublished - 2013 May

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Prone Position
Blood Pressure
Confidence Intervals
Sensitivity and Specificity
Area Under Curve
Fluid Therapy
Supine Position
Colloids
Stroke Volume
Spine

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

@article{389088139c7a4b69b91002cbbdfdafcc,
title = "Validation of pulse pressure variation and corrected flow time as predictors of fluid responsiveness in patients in the prone position",
abstract = "BackgroundThe aim of this prospective trial was to investigate the ability of pulse pressure variation (PPV) and corrected flow time (FTc) to predict fluid responsiveness in the prone position.MethodsForty-four patients undergoing lumbar spine surgery in the prone position on a Wilson frame were prospectively studied. PPV and FTc were measured before and after a colloid bolus (6 ml kg-1) both in the supine and in the prone positions. Fluid responsiveness was defined as an increase in the stroke volume index of ≥10{\%} as measured by oesophageal Doppler.ResultsIn the supine position, 26 patients were responders and the areas under the curve (AUC) of the receiver-operator characteristic (ROC) curves of PPV and FTc were 0.935 [95{\%} confidence interval (CI): 0.870-0.999, P<0.001] and 0.822 (95{\%} CI: 0.682-0.961, P<0.001), respectively. The optimal cut-off PPV and FTc values were 15{\%} (sensitivity 73{\%}, specificity 94{\%}) and 358 ms (sensitivity 88{\%}, specificity 78{\%}), respectively. In the prone position, 34 patients were responders and the AUCs of PPV and FTc were 0.969 (95{\%} CI: 0.912-1.000, P<0.001) and 0.846 (95{\%} CI: 0.706-0.985, P=0.001), respectively. The optimal cut-off PPV and FTc values were 14{\%} (sensitivity 97{\%}, specificity 90{\%}) and 331 ms (sensitivity 77{\%}, specificity 90{\%}), respectively.ConclusionsWhile the predictability of PPV was significantly higher than that of FTc in the prone position, both variables showed high predictability and remained as useful indices for guiding fluid therapy in prone patients with minimal alterations in their optimal cut-off values to predict fluid responsiveness.",
author = "Yang, {S. Y.} and Shim, {J. K.} and Y. Song and Seo, {S. J.} and Kwak, {Y. L.}",
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Validation of pulse pressure variation and corrected flow time as predictors of fluid responsiveness in patients in the prone position. / Yang, S. Y.; Shim, J. K.; Song, Y.; Seo, S. J.; Kwak, Y. L.

In: British Journal of Anaesthesia, Vol. 110, No. 5, 05.2013, p. 713-720.

Research output: Contribution to journalArticle

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N2 - BackgroundThe aim of this prospective trial was to investigate the ability of pulse pressure variation (PPV) and corrected flow time (FTc) to predict fluid responsiveness in the prone position.MethodsForty-four patients undergoing lumbar spine surgery in the prone position on a Wilson frame were prospectively studied. PPV and FTc were measured before and after a colloid bolus (6 ml kg-1) both in the supine and in the prone positions. Fluid responsiveness was defined as an increase in the stroke volume index of ≥10% as measured by oesophageal Doppler.ResultsIn the supine position, 26 patients were responders and the areas under the curve (AUC) of the receiver-operator characteristic (ROC) curves of PPV and FTc were 0.935 [95% confidence interval (CI): 0.870-0.999, P<0.001] and 0.822 (95% CI: 0.682-0.961, P<0.001), respectively. The optimal cut-off PPV and FTc values were 15% (sensitivity 73%, specificity 94%) and 358 ms (sensitivity 88%, specificity 78%), respectively. In the prone position, 34 patients were responders and the AUCs of PPV and FTc were 0.969 (95% CI: 0.912-1.000, P<0.001) and 0.846 (95% CI: 0.706-0.985, P=0.001), respectively. The optimal cut-off PPV and FTc values were 14% (sensitivity 97%, specificity 90%) and 331 ms (sensitivity 77%, specificity 90%), respectively.ConclusionsWhile the predictability of PPV was significantly higher than that of FTc in the prone position, both variables showed high predictability and remained as useful indices for guiding fluid therapy in prone patients with minimal alterations in their optimal cut-off values to predict fluid responsiveness.

AB - BackgroundThe aim of this prospective trial was to investigate the ability of pulse pressure variation (PPV) and corrected flow time (FTc) to predict fluid responsiveness in the prone position.MethodsForty-four patients undergoing lumbar spine surgery in the prone position on a Wilson frame were prospectively studied. PPV and FTc were measured before and after a colloid bolus (6 ml kg-1) both in the supine and in the prone positions. Fluid responsiveness was defined as an increase in the stroke volume index of ≥10% as measured by oesophageal Doppler.ResultsIn the supine position, 26 patients were responders and the areas under the curve (AUC) of the receiver-operator characteristic (ROC) curves of PPV and FTc were 0.935 [95% confidence interval (CI): 0.870-0.999, P<0.001] and 0.822 (95% CI: 0.682-0.961, P<0.001), respectively. The optimal cut-off PPV and FTc values were 15% (sensitivity 73%, specificity 94%) and 358 ms (sensitivity 88%, specificity 78%), respectively. In the prone position, 34 patients were responders and the AUCs of PPV and FTc were 0.969 (95% CI: 0.912-1.000, P<0.001) and 0.846 (95% CI: 0.706-0.985, P=0.001), respectively. The optimal cut-off PPV and FTc values were 14% (sensitivity 97%, specificity 90%) and 331 ms (sensitivity 77%, specificity 90%), respectively.ConclusionsWhile the predictability of PPV was significantly higher than that of FTc in the prone position, both variables showed high predictability and remained as useful indices for guiding fluid therapy in prone patients with minimal alterations in their optimal cut-off values to predict fluid responsiveness.

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