Validation of radiation volume by analysis of recurrence pattern in breast-conserving treatment for early breast cancer

Su Jung Shim, Yongbae Kim, Ki Chang Keum, Ik Jae Lee, Hy De Lee, Chang-Ok Suh

Research output: Contribution to journalArticle

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Abstract

Purpose: To assess the appropriateness of radiotherapy volume for patients receiving breast-conserving treatment (BCT) through analysis of recurrence pattern and factors affecting recurrence. Methods: From 1991 to 1996, 362 patients who received BCT were retrospectively evaluated. The radiation volume was the involved breast alone in the patients with less than 4 positive axillary lymph nodes (LNs), and breast and supraclavicular fossa in patients with 4 or more positive axillary LNs. The median follow-up period was 123 months (range, 3-169 months). Results: Ten-year overall, disease-free, local recurrence-free, and regional recurrence-free survival rates were 86.2%, 82.2%, 95.9%, and 95.2%, respectively. Among 310 patients receiving radiotherapy on the breast alone, 15 (4.8%) had regional recurrence. In particular, patients with inner quadrant lesions had high regional recurrence rates (11/98, 11.2%) (p <0.001). Conclusion: These low local recurrence rates may reveal that the current radiotherapy technique was successful. However, in cases of inner quadrant lesions, there were a considerable number of regional recurrences, even in N0 cases. This may suggest a potential role for irradiation on regional LNs in this group.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalJournal of Breast Cancer
Volume12
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1

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Breast
Radiation
Breast Neoplasms
Recurrence
Radiotherapy
Lymph Nodes
Therapeutics
Survival Rate

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "Validation of radiation volume by analysis of recurrence pattern in breast-conserving treatment for early breast cancer",
abstract = "Purpose: To assess the appropriateness of radiotherapy volume for patients receiving breast-conserving treatment (BCT) through analysis of recurrence pattern and factors affecting recurrence. Methods: From 1991 to 1996, 362 patients who received BCT were retrospectively evaluated. The radiation volume was the involved breast alone in the patients with less than 4 positive axillary lymph nodes (LNs), and breast and supraclavicular fossa in patients with 4 or more positive axillary LNs. The median follow-up period was 123 months (range, 3-169 months). Results: Ten-year overall, disease-free, local recurrence-free, and regional recurrence-free survival rates were 86.2{\%}, 82.2{\%}, 95.9{\%}, and 95.2{\%}, respectively. Among 310 patients receiving radiotherapy on the breast alone, 15 (4.8{\%}) had regional recurrence. In particular, patients with inner quadrant lesions had high regional recurrence rates (11/98, 11.2{\%}) (p <0.001). Conclusion: These low local recurrence rates may reveal that the current radiotherapy technique was successful. However, in cases of inner quadrant lesions, there were a considerable number of regional recurrences, even in N0 cases. This may suggest a potential role for irradiation on regional LNs in this group.",
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Validation of radiation volume by analysis of recurrence pattern in breast-conserving treatment for early breast cancer. / Shim, Su Jung; Kim, Yongbae; Keum, Ki Chang; Lee, Ik Jae; Lee, Hy De; Suh, Chang-Ok.

In: Journal of Breast Cancer, Vol. 12, No. 4, 01.12.2009, p. 257-264.

Research output: Contribution to journalArticle

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AU - Suh, Chang-Ok

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