Validation of Relationship between Patients’ Descriptions of Pruritus and Patient-burden of Chronic Pruritus using Structural Equation Modelling

Ji Hoon Ryoo, Seon Hwa Lee, Dae Lyong Ha, Kyung Duck Park, Jaehee Rho, Gyeong Hun Park, Byung Soo Kim, Kapsok Li, Chang Ook Park, Hye One Kim, Hei Sung Kim, Min Soo Jang, Dong Hun Lee, Yang Won Lee, Do Won Kim, Yong Hyun Jang, Seong Jin Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with chronic itch describe their pruritus in a wide variety of ways. However, these subjective descriptions are often not taken into consideration by physicians. This study aimed to validate patients’ descriptions of pruritus, and to investigate the relationship between various descriptions of pruritus and the patient burden of chronic pruritus by examining the mediating effects of sleep disturbance and sexual dysfunction on patient’s quality of life, as predicted by various descriptions of pruritus. Exploratory and confirmatory factor analyses were performed to identify the factor structure measured by 11 descriptions of pruri-tus. The study then analysed differences in the degree of sleep disturbance, sexual dysfunction, and quality of life deterioration factors using a structural equation modelling method. Using data from 419 patients with chronic pruritus, 11 descriptions of pruritus were clas-sified into 2 groups: (i) sensory pruritus (i.e. stinging, stabbing, burning, painful, formication, throbbing, and cold) that are linked with descriptions of pruritus pat-terns; and (ii) affective pruritus (i.e. annoying, unbea-rable, worrisome, and warm) from patient reports of psychological or emotional distress. The study found that affective pruritus decreases patient’s quality of life either directly or indirectly through sleep disturbance. In conclusion, clues about a patients’ sleep disturbance or poor quality of life can be obtained through their descriptions of pruritus.

Original languageEnglish
Article numberadv00819
JournalActa dermato-venereologica
Volume102
DOIs
Publication statusPublished - 2022

Bibliographical note

Funding Information:
This work was supported by the Biomedical Research Institute grant, Kyungpook National University Hospital (2021). This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI15C001).

Funding Information:
This work was supported by the Biomedical Research Institute grant, Kyungpook National University Hospital (2021). This research was also supported by a grant of the Korea Health Techno-logy R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI15C001). Reviewed and approved by the Kyungpook National University Hospital Institutional Review Board (IRB number: KNUH 2021-01-036).

Publisher Copyright:
© 2022, Medical Journals/Acta D-V. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Dermatology

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