Validation of Rome II criteria for functional gastrointestinal disorders by factor analysis of symptoms in Asian patient sample

Ambrose Chi Pong Kwan, Tran Ngoc Bao, Suriya Chakkaphak, Full Young Chang, Mei Yun Ke, Ngai Moh Law, Somchai Leelakusolvong, Jin Yan Luo, Chudahman Manan, HyoJin Park, Wanich Piyaniran, Akhtar Qureshi, Ta Long, Guo Ming Xu, Liying Xu, Hon Yuen

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Abstract

Background and Aims: It has been unclear as to whether the Rome II criteria could be applied to patients in the Asia region with functional gastrointestinal (GI) diseases. The aim of the present study was to determine if symptoms of Asian patients with functional gastrointestinal disorders formed groups which corresponded to the Rome II diagnostic criteria. Methods: A modified English version of Talley's bowel disease questionnaire was developed in collaboration with various research teams in accordance with the Rome II criteria. This instrument was translated into the local languages of the following nine Asian regions: China, Hong Kong, Indonesia, Korea, Malaysia, Singapore, Taiwan, Thailand and Vietnam. From September to December 2001, newly enrolled outpatients attending 14 GI or medical clinics in these regions were invited to complete the questionnaire. From these respondents, patients with functional gastrointestinal disorders fulfilling the '12 weeks out of 12 months' criteria were separated for further analysis. Principal component factor analysis with varimax rotation was used to identify symptom clusters or factors. These factors were compared with the existing classification of functional GI diseases derived from the Rome II criteria. Results: Factor analysis of symptoms from 1012 functional GI patients supported the Rome II classification of the following groups of functional GI disorders: diarrhea-predominant irritable bowel syndrome, functional constipation, functional dyspepsia, functional abdominal pain syndrome, functional heartburn, and functional vomiting. Functional diarrhea was combined with functional anorectal disorders, and globus merged with functional dysphagia into one factor. Some of the functional dyspepsia, abdominal bloating and belching symptoms were loaded into one factor. Conclusions: Factor analysis of symptoms from a sample of Asian patients with functional GI disorders partially supported the use of the Rome II classification.

Original languageEnglish
Pages (from-to)796-802
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume18
Issue number7
DOIs
Publication statusPublished - 2003 Jul 1

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Gastrointestinal Diseases
Statistical Factor Analysis
Dyspepsia
Diarrhea
Rectal Diseases
Eructation
Heartburn
Indonesia
Vietnam
Irritable Bowel Syndrome
Malaysia
Singapore
Hong Kong
Thailand
Constipation
Korea
Deglutition Disorders
Principal Component Analysis
Taiwan
Abdominal Pain

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kwan, Ambrose Chi Pong ; Bao, Tran Ngoc ; Chakkaphak, Suriya ; Chang, Full Young ; Ke, Mei Yun ; Law, Ngai Moh ; Leelakusolvong, Somchai ; Luo, Jin Yan ; Manan, Chudahman ; Park, HyoJin ; Piyaniran, Wanich ; Qureshi, Akhtar ; Long, Ta ; Xu, Guo Ming ; Xu, Liying ; Yuen, Hon. / Validation of Rome II criteria for functional gastrointestinal disorders by factor analysis of symptoms in Asian patient sample. In: Journal of Gastroenterology and Hepatology (Australia). 2003 ; Vol. 18, No. 7. pp. 796-802.
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abstract = "Background and Aims: It has been unclear as to whether the Rome II criteria could be applied to patients in the Asia region with functional gastrointestinal (GI) diseases. The aim of the present study was to determine if symptoms of Asian patients with functional gastrointestinal disorders formed groups which corresponded to the Rome II diagnostic criteria. Methods: A modified English version of Talley's bowel disease questionnaire was developed in collaboration with various research teams in accordance with the Rome II criteria. This instrument was translated into the local languages of the following nine Asian regions: China, Hong Kong, Indonesia, Korea, Malaysia, Singapore, Taiwan, Thailand and Vietnam. From September to December 2001, newly enrolled outpatients attending 14 GI or medical clinics in these regions were invited to complete the questionnaire. From these respondents, patients with functional gastrointestinal disorders fulfilling the '12 weeks out of 12 months' criteria were separated for further analysis. Principal component factor analysis with varimax rotation was used to identify symptom clusters or factors. These factors were compared with the existing classification of functional GI diseases derived from the Rome II criteria. Results: Factor analysis of symptoms from 1012 functional GI patients supported the Rome II classification of the following groups of functional GI disorders: diarrhea-predominant irritable bowel syndrome, functional constipation, functional dyspepsia, functional abdominal pain syndrome, functional heartburn, and functional vomiting. Functional diarrhea was combined with functional anorectal disorders, and globus merged with functional dysphagia into one factor. Some of the functional dyspepsia, abdominal bloating and belching symptoms were loaded into one factor. Conclusions: Factor analysis of symptoms from a sample of Asian patients with functional GI disorders partially supported the use of the Rome II classification.",
author = "Kwan, {Ambrose Chi Pong} and Bao, {Tran Ngoc} and Suriya Chakkaphak and Chang, {Full Young} and Ke, {Mei Yun} and Law, {Ngai Moh} and Somchai Leelakusolvong and Luo, {Jin Yan} and Chudahman Manan and HyoJin Park and Wanich Piyaniran and Akhtar Qureshi and Ta Long and Xu, {Guo Ming} and Liying Xu and Hon Yuen",
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Kwan, ACP, Bao, TN, Chakkaphak, S, Chang, FY, Ke, MY, Law, NM, Leelakusolvong, S, Luo, JY, Manan, C, Park, H, Piyaniran, W, Qureshi, A, Long, T, Xu, GM, Xu, L & Yuen, H 2003, 'Validation of Rome II criteria for functional gastrointestinal disorders by factor analysis of symptoms in Asian patient sample', Journal of Gastroenterology and Hepatology (Australia), vol. 18, no. 7, pp. 796-802. https://doi.org/10.1046/j.1440-1746.2003.03081.x

Validation of Rome II criteria for functional gastrointestinal disorders by factor analysis of symptoms in Asian patient sample. / Kwan, Ambrose Chi Pong; Bao, Tran Ngoc; Chakkaphak, Suriya; Chang, Full Young; Ke, Mei Yun; Law, Ngai Moh; Leelakusolvong, Somchai; Luo, Jin Yan; Manan, Chudahman; Park, HyoJin; Piyaniran, Wanich; Qureshi, Akhtar; Long, Ta; Xu, Guo Ming; Xu, Liying; Yuen, Hon.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 18, No. 7, 01.07.2003, p. 796-802.

Research output: Contribution to journalArticle

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T1 - Validation of Rome II criteria for functional gastrointestinal disorders by factor analysis of symptoms in Asian patient sample

AU - Kwan, Ambrose Chi Pong

AU - Bao, Tran Ngoc

AU - Chakkaphak, Suriya

AU - Chang, Full Young

AU - Ke, Mei Yun

AU - Law, Ngai Moh

AU - Leelakusolvong, Somchai

AU - Luo, Jin Yan

AU - Manan, Chudahman

AU - Park, HyoJin

AU - Piyaniran, Wanich

AU - Qureshi, Akhtar

AU - Long, Ta

AU - Xu, Guo Ming

AU - Xu, Liying

AU - Yuen, Hon

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Background and Aims: It has been unclear as to whether the Rome II criteria could be applied to patients in the Asia region with functional gastrointestinal (GI) diseases. The aim of the present study was to determine if symptoms of Asian patients with functional gastrointestinal disorders formed groups which corresponded to the Rome II diagnostic criteria. Methods: A modified English version of Talley's bowel disease questionnaire was developed in collaboration with various research teams in accordance with the Rome II criteria. This instrument was translated into the local languages of the following nine Asian regions: China, Hong Kong, Indonesia, Korea, Malaysia, Singapore, Taiwan, Thailand and Vietnam. From September to December 2001, newly enrolled outpatients attending 14 GI or medical clinics in these regions were invited to complete the questionnaire. From these respondents, patients with functional gastrointestinal disorders fulfilling the '12 weeks out of 12 months' criteria were separated for further analysis. Principal component factor analysis with varimax rotation was used to identify symptom clusters or factors. These factors were compared with the existing classification of functional GI diseases derived from the Rome II criteria. Results: Factor analysis of symptoms from 1012 functional GI patients supported the Rome II classification of the following groups of functional GI disorders: diarrhea-predominant irritable bowel syndrome, functional constipation, functional dyspepsia, functional abdominal pain syndrome, functional heartburn, and functional vomiting. Functional diarrhea was combined with functional anorectal disorders, and globus merged with functional dysphagia into one factor. Some of the functional dyspepsia, abdominal bloating and belching symptoms were loaded into one factor. Conclusions: Factor analysis of symptoms from a sample of Asian patients with functional GI disorders partially supported the use of the Rome II classification.

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