Value of additional von Kossa staining in thyroid nodules with echogenic spots on ultrasound

In Hye Chae, Hyeongju Kwon, Eunkyung Kim, Hee Jung Moon, Jung Hyun Yoon, Hye Sun Lee, jinyoung kwak

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To evaluate the clinical value of additional von Kossa staining on cytology in thyroid nodules with echogenic spots on ultrasound (US). Materials and methods: 342 thyroid nodules were analyzed for cytology and von Kossa staining was performed to detect microcalcifications. We compared diagnostic performances and accuracies of FNA and FNA with von Kossa staining to detect malignancy. We evaluated associations of aggressive pathologic features and von Kossa positivity in the surgically confirmed papillary thyroid carcinoma (PTC) group. Results: Two hundred and thirty two (67.8%) nodules were malignant and 110 (32.2%) were benign on cytopathology. Compared to cytology alone, additional von Kossa staining slightly improved sensitivity from 89.7% to 90.9% (P = 0.081). In 207 cases of surgically confirmed PTC, von Kossa positivity was an independent predictor of central lymph node metastasis in PTCs by multivariate analysis (odds ratio, 2.218; P = 0.021). Conclusions: Adding von Kossa staining to cytology improved the sensitivity of thyroid nodules with echogenic spots on US. Positive von Kossa stains in PTCs may also be useful in predicting central lymph node metastasis.

Original languageEnglish
Pages (from-to)415-420
Number of pages6
JournalPathology Research and Practice
Volume212
Issue number5
DOIs
Publication statusPublished - 2016 May 1

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Thyroid Nodule
Cell Biology
Staining and Labeling
Factor IX
Lymph Nodes
Neoplasm Metastasis
Calcinosis
Coloring Agents
Multivariate Analysis
Odds Ratio
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

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title = "Value of additional von Kossa staining in thyroid nodules with echogenic spots on ultrasound",
abstract = "Purpose: To evaluate the clinical value of additional von Kossa staining on cytology in thyroid nodules with echogenic spots on ultrasound (US). Materials and methods: 342 thyroid nodules were analyzed for cytology and von Kossa staining was performed to detect microcalcifications. We compared diagnostic performances and accuracies of FNA and FNA with von Kossa staining to detect malignancy. We evaluated associations of aggressive pathologic features and von Kossa positivity in the surgically confirmed papillary thyroid carcinoma (PTC) group. Results: Two hundred and thirty two (67.8{\%}) nodules were malignant and 110 (32.2{\%}) were benign on cytopathology. Compared to cytology alone, additional von Kossa staining slightly improved sensitivity from 89.7{\%} to 90.9{\%} (P = 0.081). In 207 cases of surgically confirmed PTC, von Kossa positivity was an independent predictor of central lymph node metastasis in PTCs by multivariate analysis (odds ratio, 2.218; P = 0.021). Conclusions: Adding von Kossa staining to cytology improved the sensitivity of thyroid nodules with echogenic spots on US. Positive von Kossa stains in PTCs may also be useful in predicting central lymph node metastasis.",
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Value of additional von Kossa staining in thyroid nodules with echogenic spots on ultrasound. / Chae, In Hye; Kwon, Hyeongju; Kim, Eunkyung; Moon, Hee Jung; Yoon, Jung Hyun; Lee, Hye Sun; kwak, jinyoung.

In: Pathology Research and Practice, Vol. 212, No. 5, 01.05.2016, p. 415-420.

Research output: Contribution to journalArticle

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AU - Yoon, Jung Hyun

AU - Lee, Hye Sun

AU - kwak, jinyoung

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N2 - Purpose: To evaluate the clinical value of additional von Kossa staining on cytology in thyroid nodules with echogenic spots on ultrasound (US). Materials and methods: 342 thyroid nodules were analyzed for cytology and von Kossa staining was performed to detect microcalcifications. We compared diagnostic performances and accuracies of FNA and FNA with von Kossa staining to detect malignancy. We evaluated associations of aggressive pathologic features and von Kossa positivity in the surgically confirmed papillary thyroid carcinoma (PTC) group. Results: Two hundred and thirty two (67.8%) nodules were malignant and 110 (32.2%) were benign on cytopathology. Compared to cytology alone, additional von Kossa staining slightly improved sensitivity from 89.7% to 90.9% (P = 0.081). In 207 cases of surgically confirmed PTC, von Kossa positivity was an independent predictor of central lymph node metastasis in PTCs by multivariate analysis (odds ratio, 2.218; P = 0.021). Conclusions: Adding von Kossa staining to cytology improved the sensitivity of thyroid nodules with echogenic spots on US. Positive von Kossa stains in PTCs may also be useful in predicting central lymph node metastasis.

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