Value of serum cystatin C measurement in the diagnosis of sepsis-induced kidney injury and prediction of renal function recovery

Ah Young Leem, Moo Suk Park, Byung Hoon Park, Won Jai Jung, Kyung Soo Chung, Song Yee Kim, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Young Sam Kim, Se Kyu Kim, Joon Chang, Joo Han Song

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: Acute kidney injury (AKI) is common in critically ill patients. Serum cystatin C has emerged as a reliable marker of AKI. We sought to assess the value of serum cystatin C for early detection and prediction of renal function recovery in patients with sepsis. Materials and Methods: Sepsis patients (113 AKI patients and 49 non-AKI patients) admitted to the intensive care unit (ICU) were included. Serum creatinine and cystatin C levels and glomerular filtration rate were measured on days 0, 1, 3, and 7. Results: Serum cystatin C levels were significantly higher in AKI patients than in non-AKI patients at all time points. Multivariate analysis showed that only serum cystatin C levels on day 0 were associated with AKI development [odds ratio (OR)=19.30; 95% confidence interval (CI)= 2.58–144.50, p<0.001]. Linear mixed model analysis showed significant variation in cystatin C levels between the recovery and non-recovery groups over time (p=0.001). High levels of serum cystatin C at day 0 (OR=1.64; 95% CI=1.00–2.68, p=0.048) were associated with recovery of AKI. Conclusion: Serum cystatin C level was found to be associated with the development and worsening of AKI in ICU patients with sepsis.

Original languageEnglish
Pages (from-to)604-612
Number of pages9
JournalYonsei medical journal
Volume58
Issue number3
DOIs
Publication statusPublished - 2017 May

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Cystatin C
Recovery of Function
Acute Kidney Injury
Sepsis
Kidney
Wounds and Injuries
Serum
Intensive Care Units
Odds Ratio
Confidence Intervals
Glomerular Filtration Rate
Critical Illness
Linear Models
Creatinine
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Leem, Ah Young ; Park, Moo Suk ; Park, Byung Hoon ; Jung, Won Jai ; Chung, Kyung Soo ; Kim, Song Yee ; Kim, Eun Young ; Jung, Ji Ye ; Kang, Young Ae ; Kim, Young Sam ; Kim, Se Kyu ; Chang, Joon ; Song, Joo Han. / Value of serum cystatin C measurement in the diagnosis of sepsis-induced kidney injury and prediction of renal function recovery. In: Yonsei medical journal. 2017 ; Vol. 58, No. 3. pp. 604-612.
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abstract = "Purpose: Acute kidney injury (AKI) is common in critically ill patients. Serum cystatin C has emerged as a reliable marker of AKI. We sought to assess the value of serum cystatin C for early detection and prediction of renal function recovery in patients with sepsis. Materials and Methods: Sepsis patients (113 AKI patients and 49 non-AKI patients) admitted to the intensive care unit (ICU) were included. Serum creatinine and cystatin C levels and glomerular filtration rate were measured on days 0, 1, 3, and 7. Results: Serum cystatin C levels were significantly higher in AKI patients than in non-AKI patients at all time points. Multivariate analysis showed that only serum cystatin C levels on day 0 were associated with AKI development [odds ratio (OR)=19.30; 95{\%} confidence interval (CI)= 2.58–144.50, p<0.001]. Linear mixed model analysis showed significant variation in cystatin C levels between the recovery and non-recovery groups over time (p=0.001). High levels of serum cystatin C at day 0 (OR=1.64; 95{\%} CI=1.00–2.68, p=0.048) were associated with recovery of AKI. Conclusion: Serum cystatin C level was found to be associated with the development and worsening of AKI in ICU patients with sepsis.",
author = "Leem, {Ah Young} and Park, {Moo Suk} and Park, {Byung Hoon} and Jung, {Won Jai} and Chung, {Kyung Soo} and Kim, {Song Yee} and Kim, {Eun Young} and Jung, {Ji Ye} and Kang, {Young Ae} and Kim, {Young Sam} and Kim, {Se Kyu} and Joon Chang and Song, {Joo Han}",
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Leem, AY, Park, MS, Park, BH, Jung, WJ, Chung, KS, Kim, SY, Kim, EY, Jung, JY, Kang, YA, Kim, YS, Kim, SK, Chang, J & Song, JH 2017, 'Value of serum cystatin C measurement in the diagnosis of sepsis-induced kidney injury and prediction of renal function recovery', Yonsei medical journal, vol. 58, no. 3, pp. 604-612. https://doi.org/10.3349/ymj.2017.58.3.604

Value of serum cystatin C measurement in the diagnosis of sepsis-induced kidney injury and prediction of renal function recovery. / Leem, Ah Young; Park, Moo Suk; Park, Byung Hoon; Jung, Won Jai; Chung, Kyung Soo; Kim, Song Yee; Kim, Eun Young; Jung, Ji Ye; Kang, Young Ae; Kim, Young Sam; Kim, Se Kyu; Chang, Joon; Song, Joo Han.

In: Yonsei medical journal, Vol. 58, No. 3, 05.2017, p. 604-612.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Value of serum cystatin C measurement in the diagnosis of sepsis-induced kidney injury and prediction of renal function recovery

AU - Leem, Ah Young

AU - Park, Moo Suk

AU - Park, Byung Hoon

AU - Jung, Won Jai

AU - Chung, Kyung Soo

AU - Kim, Song Yee

AU - Kim, Eun Young

AU - Jung, Ji Ye

AU - Kang, Young Ae

AU - Kim, Young Sam

AU - Kim, Se Kyu

AU - Chang, Joon

AU - Song, Joo Han

PY - 2017/5

Y1 - 2017/5

N2 - Purpose: Acute kidney injury (AKI) is common in critically ill patients. Serum cystatin C has emerged as a reliable marker of AKI. We sought to assess the value of serum cystatin C for early detection and prediction of renal function recovery in patients with sepsis. Materials and Methods: Sepsis patients (113 AKI patients and 49 non-AKI patients) admitted to the intensive care unit (ICU) were included. Serum creatinine and cystatin C levels and glomerular filtration rate were measured on days 0, 1, 3, and 7. Results: Serum cystatin C levels were significantly higher in AKI patients than in non-AKI patients at all time points. Multivariate analysis showed that only serum cystatin C levels on day 0 were associated with AKI development [odds ratio (OR)=19.30; 95% confidence interval (CI)= 2.58–144.50, p<0.001]. Linear mixed model analysis showed significant variation in cystatin C levels between the recovery and non-recovery groups over time (p=0.001). High levels of serum cystatin C at day 0 (OR=1.64; 95% CI=1.00–2.68, p=0.048) were associated with recovery of AKI. Conclusion: Serum cystatin C level was found to be associated with the development and worsening of AKI in ICU patients with sepsis.

AB - Purpose: Acute kidney injury (AKI) is common in critically ill patients. Serum cystatin C has emerged as a reliable marker of AKI. We sought to assess the value of serum cystatin C for early detection and prediction of renal function recovery in patients with sepsis. Materials and Methods: Sepsis patients (113 AKI patients and 49 non-AKI patients) admitted to the intensive care unit (ICU) were included. Serum creatinine and cystatin C levels and glomerular filtration rate were measured on days 0, 1, 3, and 7. Results: Serum cystatin C levels were significantly higher in AKI patients than in non-AKI patients at all time points. Multivariate analysis showed that only serum cystatin C levels on day 0 were associated with AKI development [odds ratio (OR)=19.30; 95% confidence interval (CI)= 2.58–144.50, p<0.001]. Linear mixed model analysis showed significant variation in cystatin C levels between the recovery and non-recovery groups over time (p=0.001). High levels of serum cystatin C at day 0 (OR=1.64; 95% CI=1.00–2.68, p=0.048) were associated with recovery of AKI. Conclusion: Serum cystatin C level was found to be associated with the development and worsening of AKI in ICU patients with sepsis.

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