Value of ventricular stiffness index and ventriculoarterial interaction in patients with nonischemic dilated cardiomyopathy

Young Her Ae, Jong Youn Kim, Eui Young Choi, Sung Ai Kim, Sang Jae Rhee, Young Shim Chi, Seok Min Kang, Jong Won Ha, Namsik Chung

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Whether echo-Doppler-derived index of ventricular elastance or ventriculoarterial interaction can reliably reflect circulatory efficiency in various conditions was investigated in the present study and whether they can be helpful in predicting exercise capacity in patients with dilated cardiomyopathy (DCM). Methods and Results: The 25 patients with DCM, 25 age- and gender-matched hypertensive patients, and 25 marathon runners underwent symptom-limited graded supine bicycle exercise echocardiography after resting echo-Doppler evaluation. Echo-Doppler-derived left ventricular (LV) diastolic elastance index (Ed), ventricular-vascular coupling index (10xEa/Ees), based on arterial elastance index (Ea) to LV end-systolic elastance index (Ees), and hemodynamic parameters were measured during rest and exercise. DCM patients had lower Ees, higher Ed and Ea/Ees with blunted exercise responses of Ees than the other groups, and the hypertensive patients had lower Ees and ΔEes compared with the marathon runners. Resting Ed, Ea/Ees, and total stiffness index (10x EdxEa/Ees) correlated with exercise duration independent of age and gender. A stiffness index of 0.8 could reliably predict impaired exercise capacity. Conclusions: Echo-derived elastance is predictive of exercise capacity in patients with DCM.

Original languageEnglish
Pages (from-to)1683-1690
Number of pages8
JournalCirculation Journal
Volume73
Issue number9
DOIs
Publication statusPublished - 2009 Sep 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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