Vancomycin-resistant enterococcal bacteremia in a hematology unit

Molecular epidemiology and analysis of clinical course

Jin Hong Yoo, Dong Gun Lee, Mi Choi Su, Jung Hyun Choi, Wan Shik Shin, Myungshin Kim, DongEun Yong, Kyungwon Lee, Woo Sung Min, Chun Choo Kim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

An increase in vancomycin-resistant enterococcal (VRE) bacteremia in hematooncological patients (n=19) in our institution from 2000 through 2001 led us to analyze the molecular epidemiologic patterns and clinical features unique to our cases. The pulsed field gel electrophoresis of the isolates revealed that the bacteremia was not originated from a single done but rather showed endemic pattern of diverse clones with small clusters. A different DNA pattern of blood and stool isolates from one patient suggested exogenous rather than endogenous route of infection. Enterococcus faecium carrying vanA gene was the causative pathogen in all cases. Patients with VRE bacteremia showed similar clinical courses compared with those with vancomycin-susceptible enterococcal (VSE) bacteremia. Vancomycin resistance did not seem to be a poor prognostic factor because of similar mortality (5/8, 62.5%) noted in VSE bacteremia. Initial disease severity and neutropenic status may be major determinants of prognosis in patients with VRE bacteraemia.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalJournal of Korean medical science
Volume20
Issue number2
DOIs
Publication statusPublished - 2005 Jan 1

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Molecular Epidemiology
Hematology
Vancomycin
Bacteremia
Vancomycin Resistance
Enterococcus faecium
Pulsed Field Gel Electrophoresis
Clone Cells
Mortality
DNA
Infection
Genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yoo, Jin Hong ; Lee, Dong Gun ; Su, Mi Choi ; Choi, Jung Hyun ; Shin, Wan Shik ; Kim, Myungshin ; Yong, DongEun ; Lee, Kyungwon ; Min, Woo Sung ; Kim, Chun Choo. / Vancomycin-resistant enterococcal bacteremia in a hematology unit : Molecular epidemiology and analysis of clinical course. In: Journal of Korean medical science. 2005 ; Vol. 20, No. 2. pp. 169-176.
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Vancomycin-resistant enterococcal bacteremia in a hematology unit : Molecular epidemiology and analysis of clinical course. / Yoo, Jin Hong; Lee, Dong Gun; Su, Mi Choi; Choi, Jung Hyun; Shin, Wan Shik; Kim, Myungshin; Yong, DongEun; Lee, Kyungwon; Min, Woo Sung; Kim, Chun Choo.

In: Journal of Korean medical science, Vol. 20, No. 2, 01.01.2005, p. 169-176.

Research output: Contribution to journalArticle

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