Investigation of the dielectric properties of cell membranes plays an important role in understanding the biological activities that sustain cellular life and realize cellular functionalities. Herein, the variable dielectric polarization characteristics of cell membranes are reported. In controlling the dielectric polarization of a cell using dielectrophoresis force spectroscopy, different cellular crossover frequencies were observed by modulating both the direction and sweep rate of the frequency. The crossover frequencies were used for the extraction of the variable capacitance, which is involved in the dielectric polarization across the cell membranes. In addition, this variable phenomenon was investigated by examining cells whose membranes were cholesterol-depleted with methyl-β-cyclodextrin, which verified a strong correlation between the variable dielectric polarization characteristics and membrane composition changes. This study presented the dielectric polarization properties in live cells' membranes that can be modified by the regulation of external stimuli and provided a powerful platform to explore cellular membrane dielectric polarization.
|Number of pages||7|
|Journal||Journal of Physical Chemistry Letters|
|Publication status||Published - 2020 Sept 3|
Bibliographical noteFunding Information:
This work was supported by National Research Foundation of Korea (NRF) grants (NRF-2017R1A2B2002076 and NRF-2016R1D1A1A02937019) and Brain Korea 21 Plus project (S20SR41D0101) funded by the Korean government.
© 2020 American Chemical Society.
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Physical and Theoretical Chemistry