Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients

Eun Seok Kang, Faidon Magkos, Beom Seok Kim, Rihong Zhai, Li Su, Yu Seun Kim, David C. Christiani, Hyun Chul Lee, Christos S. Mantzoros

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Context: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM. Objective: We investigated the association between PTDM and single-nucleotide polymorphisms of ADIPOQ and ADIPOR1 in a cohort of renal allograft recipients. Design, Setting, and Participants: Five hundred seventy-five patients (367 men and 208 women) who receivedkidneytransplantsbetween1989and2007, withoutahistoryofdiabetesandwithapretransplant fasting glucose concentration less than 5.5 mmol/liter. Patients were followed up for a median 10 yr. Genotypes included single-nucleotide polymorphisms of the following: ADIPOQ rs266729, rs822395, rs822396, rs2241766, and rs1501299 and ADIPOR1 rs2232853, rs12733285, and rs1342387. Results: TT-homozygotes in ADIPOQ rs1501299 [hazard ratio (HR) = 1.70, P = 0.032] had greater risk of PTDM after adjusting for age, sex, amount of weight gain, and type of immunosuppressant. There was a significant interaction between sex and ADIPOQ rs1501299 genotype (P = 0.037). In men, but not in women, TT-homozygotes in ADIPOQ rs1501299 were more likely to develop PTDM than the wild GG-homozygotes (HR = 2.50, P = 0.002), whereas GT-heterozygotes had nonsignificantly elevated risk (HR = 1.41, P = 0.128). Conclusion: Genetic variation in ADIPOQ rs1501299 is associated with PTDM in a sex-specific manner.

Original languageEnglish
Pages (from-to)E129-E135
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number1
DOIs
Publication statusPublished - 2012 Jan

Fingerprint

Adiponectin Receptors
Adiponectin
Medical problems
Allografts
Diabetes Mellitus
Genes
Kidney
Polymorphism
Homozygote
Hazards
Single Nucleotide Polymorphism
Genotype
Nucleotides
Transplants
Immunosuppressive Agents
Heterozygote
Type 2 Diabetes Mellitus
Weight Gain
Fasting
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Kang, Eun Seok ; Magkos, Faidon ; Kim, Beom Seok ; Zhai, Rihong ; Su, Li ; Kim, Yu Seun ; Christiani, David C. ; Lee, Hyun Chul ; Mantzoros, Christos S. / Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients. In: Journal of Clinical Endocrinology and Metabolism. 2012 ; Vol. 97, No. 1. pp. E129-E135.
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title = "Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients",
abstract = "Context: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM. Objective: We investigated the association between PTDM and single-nucleotide polymorphisms of ADIPOQ and ADIPOR1 in a cohort of renal allograft recipients. Design, Setting, and Participants: Five hundred seventy-five patients (367 men and 208 women) who receivedkidneytransplantsbetween1989and2007, withoutahistoryofdiabetesandwithapretransplant fasting glucose concentration less than 5.5 mmol/liter. Patients were followed up for a median 10 yr. Genotypes included single-nucleotide polymorphisms of the following: ADIPOQ rs266729, rs822395, rs822396, rs2241766, and rs1501299 and ADIPOR1 rs2232853, rs12733285, and rs1342387. Results: TT-homozygotes in ADIPOQ rs1501299 [hazard ratio (HR) = 1.70, P = 0.032] had greater risk of PTDM after adjusting for age, sex, amount of weight gain, and type of immunosuppressant. There was a significant interaction between sex and ADIPOQ rs1501299 genotype (P = 0.037). In men, but not in women, TT-homozygotes in ADIPOQ rs1501299 were more likely to develop PTDM than the wild GG-homozygotes (HR = 2.50, P = 0.002), whereas GT-heterozygotes had nonsignificantly elevated risk (HR = 1.41, P = 0.128). Conclusion: Genetic variation in ADIPOQ rs1501299 is associated with PTDM in a sex-specific manner.",
author = "Kang, {Eun Seok} and Faidon Magkos and Kim, {Beom Seok} and Rihong Zhai and Li Su and Kim, {Yu Seun} and Christiani, {David C.} and Lee, {Hyun Chul} and Mantzoros, {Christos S.}",
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Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients. / Kang, Eun Seok; Magkos, Faidon; Kim, Beom Seok; Zhai, Rihong; Su, Li; Kim, Yu Seun; Christiani, David C.; Lee, Hyun Chul; Mantzoros, Christos S.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 1, 01.2012, p. E129-E135.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients

AU - Kang, Eun Seok

AU - Magkos, Faidon

AU - Kim, Beom Seok

AU - Zhai, Rihong

AU - Su, Li

AU - Kim, Yu Seun

AU - Christiani, David C.

AU - Lee, Hyun Chul

AU - Mantzoros, Christos S.

PY - 2012/1

Y1 - 2012/1

N2 - Context: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM. Objective: We investigated the association between PTDM and single-nucleotide polymorphisms of ADIPOQ and ADIPOR1 in a cohort of renal allograft recipients. Design, Setting, and Participants: Five hundred seventy-five patients (367 men and 208 women) who receivedkidneytransplantsbetween1989and2007, withoutahistoryofdiabetesandwithapretransplant fasting glucose concentration less than 5.5 mmol/liter. Patients were followed up for a median 10 yr. Genotypes included single-nucleotide polymorphisms of the following: ADIPOQ rs266729, rs822395, rs822396, rs2241766, and rs1501299 and ADIPOR1 rs2232853, rs12733285, and rs1342387. Results: TT-homozygotes in ADIPOQ rs1501299 [hazard ratio (HR) = 1.70, P = 0.032] had greater risk of PTDM after adjusting for age, sex, amount of weight gain, and type of immunosuppressant. There was a significant interaction between sex and ADIPOQ rs1501299 genotype (P = 0.037). In men, but not in women, TT-homozygotes in ADIPOQ rs1501299 were more likely to develop PTDM than the wild GG-homozygotes (HR = 2.50, P = 0.002), whereas GT-heterozygotes had nonsignificantly elevated risk (HR = 1.41, P = 0.128). Conclusion: Genetic variation in ADIPOQ rs1501299 is associated with PTDM in a sex-specific manner.

AB - Context: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM. Objective: We investigated the association between PTDM and single-nucleotide polymorphisms of ADIPOQ and ADIPOR1 in a cohort of renal allograft recipients. Design, Setting, and Participants: Five hundred seventy-five patients (367 men and 208 women) who receivedkidneytransplantsbetween1989and2007, withoutahistoryofdiabetesandwithapretransplant fasting glucose concentration less than 5.5 mmol/liter. Patients were followed up for a median 10 yr. Genotypes included single-nucleotide polymorphisms of the following: ADIPOQ rs266729, rs822395, rs822396, rs2241766, and rs1501299 and ADIPOR1 rs2232853, rs12733285, and rs1342387. Results: TT-homozygotes in ADIPOQ rs1501299 [hazard ratio (HR) = 1.70, P = 0.032] had greater risk of PTDM after adjusting for age, sex, amount of weight gain, and type of immunosuppressant. There was a significant interaction between sex and ADIPOQ rs1501299 genotype (P = 0.037). In men, but not in women, TT-homozygotes in ADIPOQ rs1501299 were more likely to develop PTDM than the wild GG-homozygotes (HR = 2.50, P = 0.002), whereas GT-heterozygotes had nonsignificantly elevated risk (HR = 1.41, P = 0.128). Conclusion: Genetic variation in ADIPOQ rs1501299 is associated with PTDM in a sex-specific manner.

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