Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes

Eun Yeong Choe, Hye Jin Wang, Obin Kwon, Kwang Joon Kim, Bum Seok Kim, byungwan lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Eun Seok Kang, Christos S. Mantzoros

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Abstract

Objective The aim of this study was to examine the association between common polymorphisms of the adiponectin gene (ADIPOQ) and microvascular complications in patients with type 2 diabetes mellitus (T2DM). Research design and methods Rs2241766 and rs1501299 of ADIPOQ were genotyped in 708 patients with T2DM. Fundus photography, nerve conducting velocity, and urine analysis were performed to check for the presence of microvascular complications including diabetic nephropathy, retinopathy and neuropathy. Results The prevalence of diabetic nephropathy tended to be different according to rs2241766 genotype (p = 0.057) and the GG genotype of rs2241766 was associated with diabetic nephropathy [urine albumin/creatinine ratio (UACR) greater than 30 mg/g] after adjusting for age, sex, body mass index, duration of diabetes, HDL-cholesterol, smoking status, and blood pressure (odds ratio = 1.96; 95% confidence interval = 1.01-3.82, p = 0.049). Also, the G allele of rs2241766 demonstrated a trend to be associated with an increase in UACR (p = 0.087). Rs2241766 genotype was not associated with diabetic retinopathy (p = 0.955) and neuropathy (p = 0.104) or any diabetic microvascular complications (p = 0.104). There was no significant association between the rs1501299 genotype of ADIPOQ and the prevalence of diabetic retinopathy and neuropathy or any diabetic microvascular complications even after adjustment. Conclusion These data suggest that the GG genotype at rs2241766 is implicated in the pathogenesis of risk for diabetic nephropathy defined as UACR greater than 30 mg/day in patients with T2DM.

Original languageEnglish
Pages (from-to)677-685
Number of pages9
JournalMetabolism: Clinical and Experimental
Volume62
Issue number5
DOIs
Publication statusPublished - 2013 Jan 1

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Adiponectin
Diabetes Complications
Type 2 Diabetes Mellitus
Diabetic Nephropathies
Genotype
Diabetic Retinopathy
Urine
Albumins
Creatinine
Diabetic Neuropathies
Genes
Social Adjustment
Photography
HDL Cholesterol
Body Mass Index
Research Design
Smoking
Alleles
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Choe, Eun Yeong ; Wang, Hye Jin ; Kwon, Obin ; Kim, Kwang Joon ; Kim, Bum Seok ; lee, byungwan ; Ahn, Chul Woo ; Cha, Bong Soo ; Lee, Hyun Chul ; Kang, Eun Seok ; Mantzoros, Christos S. / Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes. In: Metabolism: Clinical and Experimental. 2013 ; Vol. 62, No. 5. pp. 677-685.
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abstract = "Objective The aim of this study was to examine the association between common polymorphisms of the adiponectin gene (ADIPOQ) and microvascular complications in patients with type 2 diabetes mellitus (T2DM). Research design and methods Rs2241766 and rs1501299 of ADIPOQ were genotyped in 708 patients with T2DM. Fundus photography, nerve conducting velocity, and urine analysis were performed to check for the presence of microvascular complications including diabetic nephropathy, retinopathy and neuropathy. Results The prevalence of diabetic nephropathy tended to be different according to rs2241766 genotype (p = 0.057) and the GG genotype of rs2241766 was associated with diabetic nephropathy [urine albumin/creatinine ratio (UACR) greater than 30 mg/g] after adjusting for age, sex, body mass index, duration of diabetes, HDL-cholesterol, smoking status, and blood pressure (odds ratio = 1.96; 95{\%} confidence interval = 1.01-3.82, p = 0.049). Also, the G allele of rs2241766 demonstrated a trend to be associated with an increase in UACR (p = 0.087). Rs2241766 genotype was not associated with diabetic retinopathy (p = 0.955) and neuropathy (p = 0.104) or any diabetic microvascular complications (p = 0.104). There was no significant association between the rs1501299 genotype of ADIPOQ and the prevalence of diabetic retinopathy and neuropathy or any diabetic microvascular complications even after adjustment. Conclusion These data suggest that the GG genotype at rs2241766 is implicated in the pathogenesis of risk for diabetic nephropathy defined as UACR greater than 30 mg/day in patients with T2DM.",
author = "Choe, {Eun Yeong} and Wang, {Hye Jin} and Obin Kwon and Kim, {Kwang Joon} and Kim, {Bum Seok} and byungwan lee and Ahn, {Chul Woo} and Cha, {Bong Soo} and Lee, {Hyun Chul} and Kang, {Eun Seok} and Mantzoros, {Christos S.}",
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Choe, EY, Wang, HJ, Kwon, O, Kim, KJ, Kim, BS, lee, B, Ahn, CW, Cha, BS, Lee, HC, Kang, ES & Mantzoros, CS 2013, 'Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes', Metabolism: Clinical and Experimental, vol. 62, no. 5, pp. 677-685. https://doi.org/10.1016/j.metabol.2012.11.005

Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes. / Choe, Eun Yeong; Wang, Hye Jin; Kwon, Obin; Kim, Kwang Joon; Kim, Bum Seok; lee, byungwan; Ahn, Chul Woo; Cha, Bong Soo; Lee, Hyun Chul; Kang, Eun Seok; Mantzoros, Christos S.

In: Metabolism: Clinical and Experimental, Vol. 62, No. 5, 01.01.2013, p. 677-685.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes

AU - Choe, Eun Yeong

AU - Wang, Hye Jin

AU - Kwon, Obin

AU - Kim, Kwang Joon

AU - Kim, Bum Seok

AU - lee, byungwan

AU - Ahn, Chul Woo

AU - Cha, Bong Soo

AU - Lee, Hyun Chul

AU - Kang, Eun Seok

AU - Mantzoros, Christos S.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objective The aim of this study was to examine the association between common polymorphisms of the adiponectin gene (ADIPOQ) and microvascular complications in patients with type 2 diabetes mellitus (T2DM). Research design and methods Rs2241766 and rs1501299 of ADIPOQ were genotyped in 708 patients with T2DM. Fundus photography, nerve conducting velocity, and urine analysis were performed to check for the presence of microvascular complications including diabetic nephropathy, retinopathy and neuropathy. Results The prevalence of diabetic nephropathy tended to be different according to rs2241766 genotype (p = 0.057) and the GG genotype of rs2241766 was associated with diabetic nephropathy [urine albumin/creatinine ratio (UACR) greater than 30 mg/g] after adjusting for age, sex, body mass index, duration of diabetes, HDL-cholesterol, smoking status, and blood pressure (odds ratio = 1.96; 95% confidence interval = 1.01-3.82, p = 0.049). Also, the G allele of rs2241766 demonstrated a trend to be associated with an increase in UACR (p = 0.087). Rs2241766 genotype was not associated with diabetic retinopathy (p = 0.955) and neuropathy (p = 0.104) or any diabetic microvascular complications (p = 0.104). There was no significant association between the rs1501299 genotype of ADIPOQ and the prevalence of diabetic retinopathy and neuropathy or any diabetic microvascular complications even after adjustment. Conclusion These data suggest that the GG genotype at rs2241766 is implicated in the pathogenesis of risk for diabetic nephropathy defined as UACR greater than 30 mg/day in patients with T2DM.

AB - Objective The aim of this study was to examine the association between common polymorphisms of the adiponectin gene (ADIPOQ) and microvascular complications in patients with type 2 diabetes mellitus (T2DM). Research design and methods Rs2241766 and rs1501299 of ADIPOQ were genotyped in 708 patients with T2DM. Fundus photography, nerve conducting velocity, and urine analysis were performed to check for the presence of microvascular complications including diabetic nephropathy, retinopathy and neuropathy. Results The prevalence of diabetic nephropathy tended to be different according to rs2241766 genotype (p = 0.057) and the GG genotype of rs2241766 was associated with diabetic nephropathy [urine albumin/creatinine ratio (UACR) greater than 30 mg/g] after adjusting for age, sex, body mass index, duration of diabetes, HDL-cholesterol, smoking status, and blood pressure (odds ratio = 1.96; 95% confidence interval = 1.01-3.82, p = 0.049). Also, the G allele of rs2241766 demonstrated a trend to be associated with an increase in UACR (p = 0.087). Rs2241766 genotype was not associated with diabetic retinopathy (p = 0.955) and neuropathy (p = 0.104) or any diabetic microvascular complications (p = 0.104). There was no significant association between the rs1501299 genotype of ADIPOQ and the prevalence of diabetic retinopathy and neuropathy or any diabetic microvascular complications even after adjustment. Conclusion These data suggest that the GG genotype at rs2241766 is implicated in the pathogenesis of risk for diabetic nephropathy defined as UACR greater than 30 mg/day in patients with T2DM.

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