Variation in lung function and alterations in cardiac structure and function—Analysis of the UK Biobank cardiovascular magnetic resonance imaging substudy

Ross J. Thomson, Nay Aung, Mihir M. Sanghvi, Jose Miguel Paiva, Aaron M. Lee, Filip Zemrak, Kenneth Fung, Paul E. Pfeffer, Alexander J. Mackay, Tricia M. McKeever, Elena Lukaschuk, Valentina Carapella, Youngjin Kim, Charlotte E. Bolton, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen

Research output: Contribution to journalArticle

Abstract

Background Reduced lung function is common and associated with increased cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and cardiovascular structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored. Methods UK Biobank is a prospective cohort study of community participants in the United Kingdom. Individuals self-reported demographics and co-morbidities, and a subset underwent cardiovascular magnetic resonance (CMR) imaging and spirometry. CMR images were analysed to derive ventricular volumes and mass. The relationships between CMR-derived measures and spirometry and age were modelled with multivariable linear regression, taking account of the effects of possible confounders. Results Data were available for 4,975 individuals, and after exclusion of those with pre-existing cardiorespiratory disease and unacceptable spirometry, 1,406 were included in the analyses. In fully-adjusted multivariable linear models lower FEV1 and FVC were associated with smaller left ventricular end-diastolic (−5.21ml per standard deviation (SD) change in FEV1, −5.69ml per SD change in FVC), end-systolic (−2.34ml, −2.56ml) and stroke volumes (−2.85ml, −3.11ml); right ventricular end-diastolic (−5.62ml, −5.84ml), end-systolic (−2.47ml, −2.46ml) and stroke volumes (−3.13ml, −3.36ml); and with lower left ventricular mass (−2.29g, −2.46g). Changes of comparable magnitude and direction were observed per decade increase in age. Conclusions This study shows that reduced FEV1 and FVC are associated with smaller ventricular volumes and reduced ventricular mass. The changes seen per standard deviation change in FEV1 and FVC are comparable to one decade of ageing.

Original languageEnglish
Article numbere0194434
JournalPloS one
Volume13
Issue number3
DOIs
Publication statusPublished - 2018 Mar 1

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lung function
Spirometry
Magnetic resonance
magnetic resonance imaging
Pulmonary diseases
Magnetic Resonance Imaging
Imaging techniques
Stroke Volume
Lung
Linear Models
Magnetic Resonance Spectroscopy
stroke
respiratory tract diseases
Morbidity
Preexisting Condition Coverage
Linear regression
Lung Diseases
Cohort Studies
Aging of materials
cohort studies

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Thomson, Ross J. ; Aung, Nay ; Sanghvi, Mihir M. ; Paiva, Jose Miguel ; Lee, Aaron M. ; Zemrak, Filip ; Fung, Kenneth ; Pfeffer, Paul E. ; Mackay, Alexander J. ; McKeever, Tricia M. ; Lukaschuk, Elena ; Carapella, Valentina ; Kim, Youngjin ; Bolton, Charlotte E. ; Piechnik, Stefan K. ; Neubauer, Stefan ; Petersen, Steffen E. / Variation in lung function and alterations in cardiac structure and function—Analysis of the UK Biobank cardiovascular magnetic resonance imaging substudy. In: PloS one. 2018 ; Vol. 13, No. 3.
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abstract = "Background Reduced lung function is common and associated with increased cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and cardiovascular structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored. Methods UK Biobank is a prospective cohort study of community participants in the United Kingdom. Individuals self-reported demographics and co-morbidities, and a subset underwent cardiovascular magnetic resonance (CMR) imaging and spirometry. CMR images were analysed to derive ventricular volumes and mass. The relationships between CMR-derived measures and spirometry and age were modelled with multivariable linear regression, taking account of the effects of possible confounders. Results Data were available for 4,975 individuals, and after exclusion of those with pre-existing cardiorespiratory disease and unacceptable spirometry, 1,406 were included in the analyses. In fully-adjusted multivariable linear models lower FEV1 and FVC were associated with smaller left ventricular end-diastolic (−5.21ml per standard deviation (SD) change in FEV1, −5.69ml per SD change in FVC), end-systolic (−2.34ml, −2.56ml) and stroke volumes (−2.85ml, −3.11ml); right ventricular end-diastolic (−5.62ml, −5.84ml), end-systolic (−2.47ml, −2.46ml) and stroke volumes (−3.13ml, −3.36ml); and with lower left ventricular mass (−2.29g, −2.46g). Changes of comparable magnitude and direction were observed per decade increase in age. Conclusions This study shows that reduced FEV1 and FVC are associated with smaller ventricular volumes and reduced ventricular mass. The changes seen per standard deviation change in FEV1 and FVC are comparable to one decade of ageing.",
author = "Thomson, {Ross J.} and Nay Aung and Sanghvi, {Mihir M.} and Paiva, {Jose Miguel} and Lee, {Aaron M.} and Filip Zemrak and Kenneth Fung and Pfeffer, {Paul E.} and Mackay, {Alexander J.} and McKeever, {Tricia M.} and Elena Lukaschuk and Valentina Carapella and Youngjin Kim and Bolton, {Charlotte E.} and Piechnik, {Stefan K.} and Stefan Neubauer and Petersen, {Steffen E.}",
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Thomson, RJ, Aung, N, Sanghvi, MM, Paiva, JM, Lee, AM, Zemrak, F, Fung, K, Pfeffer, PE, Mackay, AJ, McKeever, TM, Lukaschuk, E, Carapella, V, Kim, Y, Bolton, CE, Piechnik, SK, Neubauer, S & Petersen, SE 2018, 'Variation in lung function and alterations in cardiac structure and function—Analysis of the UK Biobank cardiovascular magnetic resonance imaging substudy', PloS one, vol. 13, no. 3, e0194434. https://doi.org/10.1371/journal.pone.0194434

Variation in lung function and alterations in cardiac structure and function—Analysis of the UK Biobank cardiovascular magnetic resonance imaging substudy. / Thomson, Ross J.; Aung, Nay; Sanghvi, Mihir M.; Paiva, Jose Miguel; Lee, Aaron M.; Zemrak, Filip; Fung, Kenneth; Pfeffer, Paul E.; Mackay, Alexander J.; McKeever, Tricia M.; Lukaschuk, Elena; Carapella, Valentina; Kim, Youngjin; Bolton, Charlotte E.; Piechnik, Stefan K.; Neubauer, Stefan; Petersen, Steffen E.

In: PloS one, Vol. 13, No. 3, e0194434, 01.03.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Variation in lung function and alterations in cardiac structure and function—Analysis of the UK Biobank cardiovascular magnetic resonance imaging substudy

AU - Thomson, Ross J.

AU - Aung, Nay

AU - Sanghvi, Mihir M.

AU - Paiva, Jose Miguel

AU - Lee, Aaron M.

AU - Zemrak, Filip

AU - Fung, Kenneth

AU - Pfeffer, Paul E.

AU - Mackay, Alexander J.

AU - McKeever, Tricia M.

AU - Lukaschuk, Elena

AU - Carapella, Valentina

AU - Kim, Youngjin

AU - Bolton, Charlotte E.

AU - Piechnik, Stefan K.

AU - Neubauer, Stefan

AU - Petersen, Steffen E.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background Reduced lung function is common and associated with increased cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and cardiovascular structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored. Methods UK Biobank is a prospective cohort study of community participants in the United Kingdom. Individuals self-reported demographics and co-morbidities, and a subset underwent cardiovascular magnetic resonance (CMR) imaging and spirometry. CMR images were analysed to derive ventricular volumes and mass. The relationships between CMR-derived measures and spirometry and age were modelled with multivariable linear regression, taking account of the effects of possible confounders. Results Data were available for 4,975 individuals, and after exclusion of those with pre-existing cardiorespiratory disease and unacceptable spirometry, 1,406 were included in the analyses. In fully-adjusted multivariable linear models lower FEV1 and FVC were associated with smaller left ventricular end-diastolic (−5.21ml per standard deviation (SD) change in FEV1, −5.69ml per SD change in FVC), end-systolic (−2.34ml, −2.56ml) and stroke volumes (−2.85ml, −3.11ml); right ventricular end-diastolic (−5.62ml, −5.84ml), end-systolic (−2.47ml, −2.46ml) and stroke volumes (−3.13ml, −3.36ml); and with lower left ventricular mass (−2.29g, −2.46g). Changes of comparable magnitude and direction were observed per decade increase in age. Conclusions This study shows that reduced FEV1 and FVC are associated with smaller ventricular volumes and reduced ventricular mass. The changes seen per standard deviation change in FEV1 and FVC are comparable to one decade of ageing.

AB - Background Reduced lung function is common and associated with increased cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and cardiovascular structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored. Methods UK Biobank is a prospective cohort study of community participants in the United Kingdom. Individuals self-reported demographics and co-morbidities, and a subset underwent cardiovascular magnetic resonance (CMR) imaging and spirometry. CMR images were analysed to derive ventricular volumes and mass. The relationships between CMR-derived measures and spirometry and age were modelled with multivariable linear regression, taking account of the effects of possible confounders. Results Data were available for 4,975 individuals, and after exclusion of those with pre-existing cardiorespiratory disease and unacceptable spirometry, 1,406 were included in the analyses. In fully-adjusted multivariable linear models lower FEV1 and FVC were associated with smaller left ventricular end-diastolic (−5.21ml per standard deviation (SD) change in FEV1, −5.69ml per SD change in FVC), end-systolic (−2.34ml, −2.56ml) and stroke volumes (−2.85ml, −3.11ml); right ventricular end-diastolic (−5.62ml, −5.84ml), end-systolic (−2.47ml, −2.46ml) and stroke volumes (−3.13ml, −3.36ml); and with lower left ventricular mass (−2.29g, −2.46g). Changes of comparable magnitude and direction were observed per decade increase in age. Conclusions This study shows that reduced FEV1 and FVC are associated with smaller ventricular volumes and reduced ventricular mass. The changes seen per standard deviation change in FEV1 and FVC are comparable to one decade of ageing.

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