Variations in 18F-FDG uptake in breast cancer depending on PET/CT acquisition position

J. H. Lee, T. J. Jeon, S. G. Ahn, Jeong Joon, J. W. Seok, Y. H. Ryu

Research output: Contribution to journalArticle

Abstract

Aim To evaluate the variability of quantitative 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET) combined with computed tomography (CT) parameters depending on acquisition position in a dual-position protocol for breast cancers. Materials and methods For initial staging work-up, whole-body PET/CT was first acquired in a supine position, and then followed by a regional breast scan in a prone position. The maximum standardised uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) were measured on both acquisition positions. MTV50 and TLG50 were calculated with a threshold set to be 50% of SUVmax, and MTV2.5 and TLG2.5 with a fixed SUV threshold of 2.5. Results The median SUVmax of breast cancers measured on the supine scans was 4.88, and 4.49 on the prone images (p<0.05). MTV and TLG also yielded significantly lower values from supine images. Regarding the tendency for the acquisition position to yield different results, a significant disagreement was observed between SUVmax and MTV50 and between SUVmax and TLG50 (kappa = -0156 and -0.001, respectively), while MTV2.5 and TLG2.5 showed a fair to moderate agreement with SUVmax (kappa = 0.311 and 0.416, respectively). Conclusions SUVmax, MTV, and TLG yielded lower values when acquired in the prone position compared to in the supine position. This observation could be due to the partial volume effect. When using 50% of SUVmax as a threshold, there was a significant discordance between SUVmax and volumetric parameters. Thus, acquisition position may affect quantitative PET/CT parameters and the clinical implications.

Original languageEnglish
Pages (from-to)86-91
Number of pages6
JournalClinical Radiology
Volume71
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

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Glycolysis
Tumor Burden
Prone Position
Supine Position
Breast Neoplasms
Glucose
Positron-Emission Tomography
Breast
Tomography
Positron Emission Tomography Computed Tomography

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Lee, J. H. ; Jeon, T. J. ; Ahn, S. G. ; Joon, Jeong ; Seok, J. W. ; Ryu, Y. H. / Variations in 18F-FDG uptake in breast cancer depending on PET/CT acquisition position. In: Clinical Radiology. 2016 ; Vol. 71, No. 1. pp. 86-91.
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abstract = "Aim To evaluate the variability of quantitative 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET) combined with computed tomography (CT) parameters depending on acquisition position in a dual-position protocol for breast cancers. Materials and methods For initial staging work-up, whole-body PET/CT was first acquired in a supine position, and then followed by a regional breast scan in a prone position. The maximum standardised uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) were measured on both acquisition positions. MTV50 and TLG50 were calculated with a threshold set to be 50{\%} of SUVmax, and MTV2.5 and TLG2.5 with a fixed SUV threshold of 2.5. Results The median SUVmax of breast cancers measured on the supine scans was 4.88, and 4.49 on the prone images (p<0.05). MTV and TLG also yielded significantly lower values from supine images. Regarding the tendency for the acquisition position to yield different results, a significant disagreement was observed between SUVmax and MTV50 and between SUVmax and TLG50 (kappa = -0156 and -0.001, respectively), while MTV2.5 and TLG2.5 showed a fair to moderate agreement with SUVmax (kappa = 0.311 and 0.416, respectively). Conclusions SUVmax, MTV, and TLG yielded lower values when acquired in the prone position compared to in the supine position. This observation could be due to the partial volume effect. When using 50{\%} of SUVmax as a threshold, there was a significant discordance between SUVmax and volumetric parameters. Thus, acquisition position may affect quantitative PET/CT parameters and the clinical implications.",
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Variations in 18F-FDG uptake in breast cancer depending on PET/CT acquisition position. / Lee, J. H.; Jeon, T. J.; Ahn, S. G.; Joon, Jeong; Seok, J. W.; Ryu, Y. H.

In: Clinical Radiology, Vol. 71, No. 1, 01.01.2016, p. 86-91.

Research output: Contribution to journalArticle

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