Variations of Prevalence and Incidence of Atrial Fibrillation and Oral Anticoagulation Rate According to Different Analysis Approaches

Pil Sung Yang, Soorack Ryu, Daehoon Kim, Eunsun Jang, Hee Tae Yu, Tae Hoon Kim, Jinseub Hwang, Boyoung Joung, Gregory Y.H. Lip

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The reported incidence and prevalence of atrial fibrillation (AF) has been inconsistent across published studies. Using the National Health Insurance Service database of Korea, the prevalence and incidence of AF, and oral anticoagulation (OAC) use of AF patients were explored according to three different approaches; 'formal approach', considering individual AF diagnosis and mortality; 'limited diagnosis approach', using upper 5 main diagnosis; and 'medical use approach', using the number of medical use AF population by year without considering individual AF history and mortality. The AF prevalence progressively increased by 2.46-fold from 0.50% in 2004 to 1.54% in 2015 when using a 'formal approach' (p for trend <0.001). The overall prevalence was 1.09% and 0.97% when using a 'formal approach' and 'limited diagnosis approaches', respectively. Overall prevalence decreased to 0.52% with a 'medical use approach'. The trend of annual AF incidence was stable when using a 'formal approach', but increased by 15% when using a 'medical use approach'. OAC rate in 2015 was 2.1 times higher when using a 'medical use approach' compared to using a 'formal approach' (40.3% vs. 19.1%, p < 0.001). Given the wide variability in prevalence and incidence figures with different analysis approaches, careful attention to the analysis methodology is needed.

Original languageEnglish
Article number6856
JournalScientific reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

Fingerprint

Atrial Fibrillation
Incidence
National Health Programs
Mortality
Korea
Databases
Population

All Science Journal Classification (ASJC) codes

  • General

Cite this

Yang, Pil Sung ; Ryu, Soorack ; Kim, Daehoon ; Jang, Eunsun ; Yu, Hee Tae ; Kim, Tae Hoon ; Hwang, Jinseub ; Joung, Boyoung ; Lip, Gregory Y.H. / Variations of Prevalence and Incidence of Atrial Fibrillation and Oral Anticoagulation Rate According to Different Analysis Approaches. In: Scientific reports. 2018 ; Vol. 8, No. 1.
@article{cb31b77480a54a13907dade7d5f0c5e9,
title = "Variations of Prevalence and Incidence of Atrial Fibrillation and Oral Anticoagulation Rate According to Different Analysis Approaches",
abstract = "The reported incidence and prevalence of atrial fibrillation (AF) has been inconsistent across published studies. Using the National Health Insurance Service database of Korea, the prevalence and incidence of AF, and oral anticoagulation (OAC) use of AF patients were explored according to three different approaches; 'formal approach', considering individual AF diagnosis and mortality; 'limited diagnosis approach', using upper 5 main diagnosis; and 'medical use approach', using the number of medical use AF population by year without considering individual AF history and mortality. The AF prevalence progressively increased by 2.46-fold from 0.50{\%} in 2004 to 1.54{\%} in 2015 when using a 'formal approach' (p for trend <0.001). The overall prevalence was 1.09{\%} and 0.97{\%} when using a 'formal approach' and 'limited diagnosis approaches', respectively. Overall prevalence decreased to 0.52{\%} with a 'medical use approach'. The trend of annual AF incidence was stable when using a 'formal approach', but increased by 15{\%} when using a 'medical use approach'. OAC rate in 2015 was 2.1 times higher when using a 'medical use approach' compared to using a 'formal approach' (40.3{\%} vs. 19.1{\%}, p < 0.001). Given the wide variability in prevalence and incidence figures with different analysis approaches, careful attention to the analysis methodology is needed.",
author = "Yang, {Pil Sung} and Soorack Ryu and Daehoon Kim and Eunsun Jang and Yu, {Hee Tae} and Kim, {Tae Hoon} and Jinseub Hwang and Boyoung Joung and Lip, {Gregory Y.H.}",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41598-018-25111-6",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

Variations of Prevalence and Incidence of Atrial Fibrillation and Oral Anticoagulation Rate According to Different Analysis Approaches. / Yang, Pil Sung; Ryu, Soorack; Kim, Daehoon; Jang, Eunsun; Yu, Hee Tae; Kim, Tae Hoon; Hwang, Jinseub; Joung, Boyoung; Lip, Gregory Y.H.

In: Scientific reports, Vol. 8, No. 1, 6856, 01.12.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Variations of Prevalence and Incidence of Atrial Fibrillation and Oral Anticoagulation Rate According to Different Analysis Approaches

AU - Yang, Pil Sung

AU - Ryu, Soorack

AU - Kim, Daehoon

AU - Jang, Eunsun

AU - Yu, Hee Tae

AU - Kim, Tae Hoon

AU - Hwang, Jinseub

AU - Joung, Boyoung

AU - Lip, Gregory Y.H.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The reported incidence and prevalence of atrial fibrillation (AF) has been inconsistent across published studies. Using the National Health Insurance Service database of Korea, the prevalence and incidence of AF, and oral anticoagulation (OAC) use of AF patients were explored according to three different approaches; 'formal approach', considering individual AF diagnosis and mortality; 'limited diagnosis approach', using upper 5 main diagnosis; and 'medical use approach', using the number of medical use AF population by year without considering individual AF history and mortality. The AF prevalence progressively increased by 2.46-fold from 0.50% in 2004 to 1.54% in 2015 when using a 'formal approach' (p for trend <0.001). The overall prevalence was 1.09% and 0.97% when using a 'formal approach' and 'limited diagnosis approaches', respectively. Overall prevalence decreased to 0.52% with a 'medical use approach'. The trend of annual AF incidence was stable when using a 'formal approach', but increased by 15% when using a 'medical use approach'. OAC rate in 2015 was 2.1 times higher when using a 'medical use approach' compared to using a 'formal approach' (40.3% vs. 19.1%, p < 0.001). Given the wide variability in prevalence and incidence figures with different analysis approaches, careful attention to the analysis methodology is needed.

AB - The reported incidence and prevalence of atrial fibrillation (AF) has been inconsistent across published studies. Using the National Health Insurance Service database of Korea, the prevalence and incidence of AF, and oral anticoagulation (OAC) use of AF patients were explored according to three different approaches; 'formal approach', considering individual AF diagnosis and mortality; 'limited diagnosis approach', using upper 5 main diagnosis; and 'medical use approach', using the number of medical use AF population by year without considering individual AF history and mortality. The AF prevalence progressively increased by 2.46-fold from 0.50% in 2004 to 1.54% in 2015 when using a 'formal approach' (p for trend <0.001). The overall prevalence was 1.09% and 0.97% when using a 'formal approach' and 'limited diagnosis approaches', respectively. Overall prevalence decreased to 0.52% with a 'medical use approach'. The trend of annual AF incidence was stable when using a 'formal approach', but increased by 15% when using a 'medical use approach'. OAC rate in 2015 was 2.1 times higher when using a 'medical use approach' compared to using a 'formal approach' (40.3% vs. 19.1%, p < 0.001). Given the wide variability in prevalence and incidence figures with different analysis approaches, careful attention to the analysis methodology is needed.

UR - http://www.scopus.com/inward/record.url?scp=85046497081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046497081&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-25111-6

DO - 10.1038/s41598-018-25111-6

M3 - Article

C2 - 29717165

AN - SCOPUS:85046497081

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 6856

ER -