Vascular endothelial growth factor, soluble Fms-like tyrosine kinase 1, and the severity of coronary artery disease

Soo Young Kim, Sang Hak Lee, Sungha Park, seokmin kang, Namsik Chung, Won Heum Shim, Seung Yun Cho, Ha Jee Sun Ha Jee, Ichiro Manabe, Yangsoo Jang

Research output: Contribution to journalArticle

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Abstract

Background: The association between vascular endothelial growth factor (VEGF), soluble fms-like tyrosine kinase 1 (sFlt-1), and coronary artery disease (CAD) was investigated. Methods: We enrolled 112 hypertensive patients with proven CAD and 112 hypertensive controls matched for age and gender. The severity of CAD was assessed by the most severe clinical presentation of CAD in patients' history and by the number of diseased vessels. Results: Vascular endothelial growth factor level was lower, whereas sFlt-1 level was higher in the CAD group compared to the controls. Diabetes mellitus (P =.001), smoking (P =.004), and higher sFlt-1 level (P =.01) were independently associated with CAD. Younger age (P =.02), smoking (P =.049), and higher VEGF levels (P =.02) were independently associated with a history of myocardial infarction (MI), whereas higher sFlt-1 level (P =.01) was independently associated with multivessel disease. Conclusion: Plasma sFlt-1 levels are positively associated with the presence of CAD and are associated with angiographical severity of CAD.

Original languageEnglish
Pages (from-to)176-183
Number of pages8
JournalAngiology
Volume62
Issue number2
DOIs
Publication statusPublished - 2011 Feb 1

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Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor A
Coronary Artery Disease
Smoking
Diabetes Mellitus
History
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kim, Soo Young ; Lee, Sang Hak ; Park, Sungha ; kang, seokmin ; Chung, Namsik ; Shim, Won Heum ; Cho, Seung Yun ; Sun Ha Jee, Ha Jee ; Manabe, Ichiro ; Jang, Yangsoo. / Vascular endothelial growth factor, soluble Fms-like tyrosine kinase 1, and the severity of coronary artery disease. In: Angiology. 2011 ; Vol. 62, No. 2. pp. 176-183.
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Vascular endothelial growth factor, soluble Fms-like tyrosine kinase 1, and the severity of coronary artery disease. / Kim, Soo Young; Lee, Sang Hak; Park, Sungha; kang, seokmin; Chung, Namsik; Shim, Won Heum; Cho, Seung Yun; Sun Ha Jee, Ha Jee; Manabe, Ichiro; Jang, Yangsoo.

In: Angiology, Vol. 62, No. 2, 01.02.2011, p. 176-183.

Research output: Contribution to journalArticle

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AU - Kim, Soo Young

AU - Lee, Sang Hak

AU - Park, Sungha

AU - kang, seokmin

AU - Chung, Namsik

AU - Shim, Won Heum

AU - Cho, Seung Yun

AU - Sun Ha Jee, Ha Jee

AU - Manabe, Ichiro

AU - Jang, Yangsoo

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N2 - Background: The association between vascular endothelial growth factor (VEGF), soluble fms-like tyrosine kinase 1 (sFlt-1), and coronary artery disease (CAD) was investigated. Methods: We enrolled 112 hypertensive patients with proven CAD and 112 hypertensive controls matched for age and gender. The severity of CAD was assessed by the most severe clinical presentation of CAD in patients' history and by the number of diseased vessels. Results: Vascular endothelial growth factor level was lower, whereas sFlt-1 level was higher in the CAD group compared to the controls. Diabetes mellitus (P =.001), smoking (P =.004), and higher sFlt-1 level (P =.01) were independently associated with CAD. Younger age (P =.02), smoking (P =.049), and higher VEGF levels (P =.02) were independently associated with a history of myocardial infarction (MI), whereas higher sFlt-1 level (P =.01) was independently associated with multivessel disease. Conclusion: Plasma sFlt-1 levels are positively associated with the presence of CAD and are associated with angiographical severity of CAD.

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