Vascular soft-tissue sarcomas: A prognostic model from a retrospective single-center study

Kyoung Sook Park, Hyo Song Kim, Yong Jin Cho, Sun Young Rha, Joong Bae Ahn, Woo Ik Yang, Young Han Lee, Jin Suck Suh, Kyoo Ho Shin, Jae Kyung Roh

Research output: Contribution to journalArticle

Abstract

Background: Vascular soft-tissue sarcomas are a rare form of sarcoma. Malignant subtypes exhibit a variety of biological behaviors. We describe the clinicopathological characteristics and patient survival outcomes of malignant vascular soft-tissue sarcomas. Methods: We conducted a retrospective study on a cohort of 84 patients diagnosed with vascular tumors by histological examination at the Yonsei University College of Medicine between April 1987 and August 2011. The primary end point was overall survival (OS). Results: The angiosarcoma patients had a significantly shorter OS than the patients with other subtypes of sarcomas (59.0 and 142.7 months, respectively; p < 0.001). Upon multivariate analysis of survival in patients who underwent surgical resection, the following independent prognostic factors were identified: primary site (trunk, p = 0.001), age (older than 65 years, p < 0.001), pathology (angiosarcoma, p = 0.006) and R2 resection (p = 0.002). Conclusion: The independent prognostic factors for shorter survival are the trunk as the primary site, malignant angiosarcoma and age (>65 years). Complete excision should be attempted for providing a survival advantage in the patients with localized disease. In addition, bleeding episodes are much more frequent in patients with a poor survival outcome.

Original languageEnglish
Pages (from-to)329-335
Number of pages7
JournalOncology (Switzerland)
Volume86
Issue number5-6
DOIs
Publication statusPublished - 2014 Jul

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Park, K. S., Kim, H. S., Cho, Y. J., Rha, S. Y., Ahn, J. B., Yang, W. I., Lee, Y. H., Suh, J. S., Shin, K. H., & Roh, J. K. (2014). Vascular soft-tissue sarcomas: A prognostic model from a retrospective single-center study. Oncology (Switzerland), 86(5-6), 329-335. https://doi.org/10.1159/000358804