Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375

Nyung Kim, Mi Jin Sohn, Chang Jin Kim, Ho Jeong Kwon, Won Gon Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC 50 of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 μg/mL, respectively.

Original languageEnglish
Pages (from-to)2503-2506
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number7
DOIs
Publication statusPublished - 2012 Apr 1

Fingerprint

Penicillium
Staphylococcus aureus
Oxidoreductases
Methicillin-Resistant Staphylococcus aureus
Spectrum analysis
verrulactone A
verrulactone B
alternariol

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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abstract = "New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC 50 of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 μg/mL, respectively.",
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Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375. / Kim, Nyung; Sohn, Mi Jin; Kim, Chang Jin; Kwon, Ho Jeong; Kim, Won Gon.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 7, 01.04.2012, p. 2503-2506.

Research output: Contribution to journalArticle

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