Vertical nanowire probes for intracellular signaling of living cells

Ki Young Lee, Ilsoo Kim, So Eun Kim, Du Won Jeong, Ju Jin Kim, Hyewhon Rhim, Jae Pyeong Ahn, Seung Han Park, Heon Jin Choi

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The single living cell action potential was measured in an intracellular mode by using a vertical nanoelectrode. For intracellular interfacing, Si nanowires were vertically grown in a controlled manner, and optimum conditions, such as diameter, length, and nanowire density, were determined by culturing cells on the nanowires. Vertical nanowire probes were then fabricated with a complimentary metal-oxide-semiconductor (CMOS) process including sequential deposition of the passivation and electrode layers on the nanowires, and a subsequent partial etching process. The fabricated nanowire probes had an approximately 60-nm diameter and were intracellular. These probes interfaced with a GH3 cell and measured the spontaneous action potential. It successfully measured the action potential, which rapidly reached a steady state with average peak amplitude of approximately 10 mV, duration of approximately 140 ms, and period of 0.9 Hz.

Original languageEnglish
Article number56
Pages (from-to)1-7
Number of pages7
JournalNanoscale Research Letters
Issue number1
Publication statusPublished - 2014

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant, funded by the Korea government (MEST) (no. 2012R1A2A1A03010558) and the Pioneer Research Program for Converging Technology (no. 2009-008-1529) through the Korea Science and Engineering Foundation funded by the Ministry of Education, Science & Technology.

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics


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