Vestibular imbalance associated with a lesion in the nucleus prepositus hypoglossi area

Sang Won Seo, Ha Young Shin, Seo Hyun Kim, Sang Won Han, Kyung Yul Lee, Seung Min Kim, Jihoe Heo

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: The nucleus prepositus hypoglossi (NPH) is known to be a neural integrator of horizontal eye movements. Although the role of the human NPH is not well known, it may also function in postural balance, in view of its anatomic connections with the vestibular nuclei and vestibulocerebellum and of lesion studies in experimental animals. Objective: To show that the human NPH contributes to vestibular function in addition to eye movement control. Design: Case series. Setting: University hospital. Patients: Six patients with small and discrete brain-stem infarctions that predominantly involved the NPH-region. Main Outcome Measure: Findings on magnetic resonance images. Results: The NPH was affected at the lower pontine level in 2 patients and at the upper medullary level in 4. In addition to gaze-evoked nystagmus, all patients had vertigo, vomiting, and postural ataxia, suggesting vestibular dysfunction. The patients typically fell contralaterally or bilaterally to the lesion side. Conclusion: The NPH serves a vestibular function in addition to its oculomotor control function.

Original languageEnglish
Pages (from-to)1440-1443
Number of pages4
JournalArchives of Neurology
Volume61
Issue number9
DOIs
Publication statusPublished - 2004 Sep 1

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Eye Movements
Postural Balance
Brain Stem Infarctions
Vestibular Nuclei
Vertigo
Ataxia
Vomiting
Magnetic Resonance Spectroscopy
Outcome Assessment (Health Care)
Lesion
Nucleus
Animals
Case Series

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Seo, Sang Won ; Shin, Ha Young ; Kim, Seo Hyun ; Han, Sang Won ; Lee, Kyung Yul ; Kim, Seung Min ; Heo, Jihoe. / Vestibular imbalance associated with a lesion in the nucleus prepositus hypoglossi area. In: Archives of Neurology. 2004 ; Vol. 61, No. 9. pp. 1440-1443.
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Vestibular imbalance associated with a lesion in the nucleus prepositus hypoglossi area. / Seo, Sang Won; Shin, Ha Young; Kim, Seo Hyun; Han, Sang Won; Lee, Kyung Yul; Kim, Seung Min; Heo, Jihoe.

In: Archives of Neurology, Vol. 61, No. 9, 01.09.2004, p. 1440-1443.

Research output: Contribution to journalArticle

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