Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome

Heyon Na Jo; Jieun Kim; Seong Yeon Hwang; Jun Won Seo; Da Young Kim; Na Ra Yun; Dong Min Kim; Choon Mee Kim; Sook In Jung; Uh Jin Kim; Seong Eun Kim; Hyunah Kim; Eu Suk Kim; Jian Hur; Young Keun Kim; Hye Won Jeong; Jung Yeon Heo; Dong Sik Jung; Hyungdon Lee; Sun Hee Park; Yee Gyung Kwak; Sujin Lee; Seungjin Lim

doi:10.3390/v14050881

Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome

Heyon Na Jo, Jieun Kim, Seong Yeon Hwang, Jun Won Seo, Da Young Kim, Na Ra Yun, Dong Min Kim, Choon Mee Kim, Sook In Jung, Uh Jin Kim, Seong Eun Kim, Hyunah Kim, Eu Suk Kim, Jian Hur, Young Keun Kim, Hye Won Jeong, Jung Yeon Heo, Dong Sik Jung, Hyungdon Lee, Sun Hee ParkYee Gyung Kwak, Sujin Lee, Seungjin Lim

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years) (p = 0.003). The survival rates were 91.7% and 8.3% in patients with Ct values ≥30 and differed significantly (p = 0.001) in the survival and non-survival groups, respectively. The survival rates were 52.4% and 47.6% in patients with viral copy numbers ≥10,000 and 94.3% and 5.7% in patients with viral copy numbers <10,000 in the survival and non-survival groups, respectively (p = 0.001). In a multivariate analysis, viral copy numbers and initial Acute Psychologic Assessment and Chronic Health Evaluation II (APACHE II) scores were identified as the factors affecting fatality (p = 0.015 and 0.011, respectively). SFTS viral RNA loads can be useful markers for the clinical prediction of mortality and survival.

Original language	English
Article number	881
Journal	Viruses
Volume	14
Issue number	5
DOIs	https://doi.org/10.3390/v14050881
Publication status	Published - 2022 May

Bibliographical note

Funding Information:
Funding: This study was supported by a research fund from Chosun University Hospital, 2021. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2022, MDPI. All rights reserved.

All Science Journal Classification (ASJC) codes

Infectious Diseases
Virology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Jo, H. N., Kim, J., Hwang, S. Y., Seo, J. W., Kim, D. Y., Yun, N. R., Kim, D. M., Kim, C. M., Jung, S. I., Kim, U. J., Kim, S. E., Kim, H., Kim, E. S., Hur, J., Kim, Y. K., Jeong, H. W., Heo, J. Y., Jung, D. S., Lee, H., ... Lim, S. (2022). Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome. Viruses, 14(5), [881]. https://doi.org/10.3390/v14050881

@article{eeab54b56ac841519ca77af9773bad45,

title = "Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome",

abstract = "The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years) (p = 0.003). The survival rates were 91.7% and 8.3% in patients with Ct values ≥30 and differed significantly (p = 0.001) in the survival and non-survival groups, respectively. The survival rates were 52.4% and 47.6% in patients with viral copy numbers ≥10,000 and 94.3% and 5.7% in patients with viral copy numbers <10,000 in the survival and non-survival groups, respectively (p = 0.001). In a multivariate analysis, viral copy numbers and initial Acute Psychologic Assessment and Chronic Health Evaluation II (APACHE II) scores were identified as the factors affecting fatality (p = 0.015 and 0.011, respectively). SFTS viral RNA loads can be useful markers for the clinical prediction of mortality and survival.",

author = "Jo, {Heyon Na} and Jieun Kim and Hwang, {Seong Yeon} and Seo, {Jun Won} and Kim, {Da Young} and Yun, {Na Ra} and Kim, {Dong Min} and Kim, {Choon Mee} and Jung, {Sook In} and Kim, {Uh Jin} and Kim, {Seong Eun} and Hyunah Kim and Kim, {Eu Suk} and Jian Hur and Kim, {Young Keun} and Jeong, {Hye Won} and Heo, {Jung Yeon} and Jung, {Dong Sik} and Hyungdon Lee and Park, {Sun Hee} and Kwak, {Yee Gyung} and Sujin Lee and Seungjin Lim",

note = "Funding Information: Funding: This study was supported by a research fund from Chosun University Hospital, 2021. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2022, MDPI. All rights reserved.",

year = "2022",

month = may,

doi = "10.3390/v14050881",

language = "English",

volume = "14",

journal = "Viruses",

issn = "1999-4915",

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Jo, HN, Kim, J, Hwang, SY, Seo, JW, Kim, DY, Yun, NR, Kim, DM, Kim, CM, Jung, SI, Kim, UJ, Kim, SE, Kim, H, Kim, ES, Hur, J, Kim, YK, Jeong, HW, Heo, JY, Jung, DS, Lee, H, Park, SH, Kwak, YG, Lee, S & Lim, S 2022, 'Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome', Viruses, vol. 14, no. 5, 881. https://doi.org/10.3390/v14050881

TY - JOUR

T1 - Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome

AU - Jo, Heyon Na

AU - Kim, Jieun

AU - Hwang, Seong Yeon

AU - Seo, Jun Won

AU - Kim, Da Young

AU - Yun, Na Ra

AU - Kim, Dong Min

AU - Kim, Choon Mee

AU - Jung, Sook In

AU - Kim, Uh Jin

AU - Kim, Seong Eun

AU - Kim, Hyunah

AU - Kim, Eu Suk

AU - Hur, Jian

AU - Kim, Young Keun

AU - Jeong, Hye Won

AU - Heo, Jung Yeon

AU - Jung, Dong Sik

AU - Lee, Hyungdon

AU - Park, Sun Hee

AU - Kwak, Yee Gyung

AU - Lee, Sujin

AU - Lim, Seungjin

N1 - Funding Information: Funding: This study was supported by a research fund from Chosun University Hospital, 2021. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022, MDPI. All rights reserved.

PY - 2022/5

Y1 - 2022/5

N2 - The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years) (p = 0.003). The survival rates were 91.7% and 8.3% in patients with Ct values ≥30 and differed significantly (p = 0.001) in the survival and non-survival groups, respectively. The survival rates were 52.4% and 47.6% in patients with viral copy numbers ≥10,000 and 94.3% and 5.7% in patients with viral copy numbers <10,000 in the survival and non-survival groups, respectively (p = 0.001). In a multivariate analysis, viral copy numbers and initial Acute Psychologic Assessment and Chronic Health Evaluation II (APACHE II) scores were identified as the factors affecting fatality (p = 0.015 and 0.011, respectively). SFTS viral RNA loads can be useful markers for the clinical prediction of mortality and survival.

AB - The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years) (p = 0.003). The survival rates were 91.7% and 8.3% in patients with Ct values ≥30 and differed significantly (p = 0.001) in the survival and non-survival groups, respectively. The survival rates were 52.4% and 47.6% in patients with viral copy numbers ≥10,000 and 94.3% and 5.7% in patients with viral copy numbers <10,000 in the survival and non-survival groups, respectively (p = 0.001). In a multivariate analysis, viral copy numbers and initial Acute Psychologic Assessment and Chronic Health Evaluation II (APACHE II) scores were identified as the factors affecting fatality (p = 0.015 and 0.011, respectively). SFTS viral RNA loads can be useful markers for the clinical prediction of mortality and survival.

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U2 - 10.3390/v14050881

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VL - 14

JO - Viruses

JF - Viruses

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ER -

Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome

Abstract

Bibliographical note

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UN SDGs

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