Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients

Jong Suk Park, Min Ho Cho, Ji Sun Nam, Chul Woo Ahn, Bong Soo Cha, Eunjig Lee, Sungkil Lim, Kyung Rae Kim, Hyun Chul Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The inflammatory marker, C-reactive protein (CRP) is associated with long-term cardiovascular events. The aim of the study was to investigate the factors contributing to serum CRP, assess the relationship between CRP level and the parameters of visceral obesity, and examine the association between leptin and CRP level in type 2 diabetic patients. 150 patients with type 2 diabetes were enrolled. These patients were recently diagnosed (≤3 years) with type 2 diabetes and were drug naive or taking sulfonylureas only. BMI, WC, and serum concentration of CRP, glycosylated hemoglobin (HbA1c), glucose, lipids, plasminogen activator-1 (PAI-1) and leptin were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). We measured the carotid intima-media thickness (IMT). Fat mass assessed by dual-energy X-ray absorptionmetry and abdominal fat distribution was determined by CT scan. Serum concentration of CRP was significantly correlated with BMI (γ = 0.257, P<0.01), WC (γ = 0.293, P<0.01), fat mass (γ = 0.213, P<0.01), total adipose tissue (γ = 0.263, P<0.01), visceral adipose tissue (γ = 0.296, P<0.01), insulin (γ = 0.189, P = 0.047), PAI-1 (γ = 0.206, P<0.01), leptin (γ = 0.322, P<0.01), mean IMT (γ = 0.132, P = 0.042), and HOMA-IR (γ = 0.172, P = 0.045). After adjustment for age and gender, multiple regression analysis showed that serum CRP was significantly associated with leptin (β = 0.326, P = 0.01) and visceral adipose tissue (β = 0.265, P = 0.035). In conclusion, serum CRP level is significantly associated with obesity, especially the visceral adipose tissue, and serum leptin is another important independent factor associated with CRP in Korean type 2 diabetic patients.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalActa Diabetologica
Volume47
Issue number2
DOIs
Publication statusPublished - 2010 Jun 1

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Adiposity
Leptin
C-Reactive Protein
Intra-Abdominal Fat
Blood Proteins
Plasminogen Activators
Type 2 Diabetes Mellitus
Insulin Resistance
Serum
Fats
Abdominal Fat
Carotid Intima-Media Thickness
Abdominal Obesity
Glycosylated Hemoglobin A
Adipose Tissue
Homeostasis
Obesity
Regression Analysis
X-Rays
Insulin

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Park, Jong Suk ; Cho, Min Ho ; Nam, Ji Sun ; Ahn, Chul Woo ; Cha, Bong Soo ; Lee, Eunjig ; Lim, Sungkil ; Kim, Kyung Rae ; Lee, Hyun Chul. / Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients. In: Acta Diabetologica. 2010 ; Vol. 47, No. 2. pp. 113-118.
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abstract = "The inflammatory marker, C-reactive protein (CRP) is associated with long-term cardiovascular events. The aim of the study was to investigate the factors contributing to serum CRP, assess the relationship between CRP level and the parameters of visceral obesity, and examine the association between leptin and CRP level in type 2 diabetic patients. 150 patients with type 2 diabetes were enrolled. These patients were recently diagnosed (≤3 years) with type 2 diabetes and were drug naive or taking sulfonylureas only. BMI, WC, and serum concentration of CRP, glycosylated hemoglobin (HbA1c), glucose, lipids, plasminogen activator-1 (PAI-1) and leptin were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). We measured the carotid intima-media thickness (IMT). Fat mass assessed by dual-energy X-ray absorptionmetry and abdominal fat distribution was determined by CT scan. Serum concentration of CRP was significantly correlated with BMI (γ = 0.257, P<0.01), WC (γ = 0.293, P<0.01), fat mass (γ = 0.213, P<0.01), total adipose tissue (γ = 0.263, P<0.01), visceral adipose tissue (γ = 0.296, P<0.01), insulin (γ = 0.189, P = 0.047), PAI-1 (γ = 0.206, P<0.01), leptin (γ = 0.322, P<0.01), mean IMT (γ = 0.132, P = 0.042), and HOMA-IR (γ = 0.172, P = 0.045). After adjustment for age and gender, multiple regression analysis showed that serum CRP was significantly associated with leptin (β = 0.326, P = 0.01) and visceral adipose tissue (β = 0.265, P = 0.035). In conclusion, serum CRP level is significantly associated with obesity, especially the visceral adipose tissue, and serum leptin is another important independent factor associated with CRP in Korean type 2 diabetic patients.",
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Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients. / Park, Jong Suk; Cho, Min Ho; Nam, Ji Sun; Ahn, Chul Woo; Cha, Bong Soo; Lee, Eunjig; Lim, Sungkil; Kim, Kyung Rae; Lee, Hyun Chul.

In: Acta Diabetologica, Vol. 47, No. 2, 01.06.2010, p. 113-118.

Research output: Contribution to journalArticle

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T1 - Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients

AU - Park, Jong Suk

AU - Cho, Min Ho

AU - Nam, Ji Sun

AU - Ahn, Chul Woo

AU - Cha, Bong Soo

AU - Lee, Eunjig

AU - Lim, Sungkil

AU - Kim, Kyung Rae

AU - Lee, Hyun Chul

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N2 - The inflammatory marker, C-reactive protein (CRP) is associated with long-term cardiovascular events. The aim of the study was to investigate the factors contributing to serum CRP, assess the relationship between CRP level and the parameters of visceral obesity, and examine the association between leptin and CRP level in type 2 diabetic patients. 150 patients with type 2 diabetes were enrolled. These patients were recently diagnosed (≤3 years) with type 2 diabetes and were drug naive or taking sulfonylureas only. BMI, WC, and serum concentration of CRP, glycosylated hemoglobin (HbA1c), glucose, lipids, plasminogen activator-1 (PAI-1) and leptin were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). We measured the carotid intima-media thickness (IMT). Fat mass assessed by dual-energy X-ray absorptionmetry and abdominal fat distribution was determined by CT scan. Serum concentration of CRP was significantly correlated with BMI (γ = 0.257, P<0.01), WC (γ = 0.293, P<0.01), fat mass (γ = 0.213, P<0.01), total adipose tissue (γ = 0.263, P<0.01), visceral adipose tissue (γ = 0.296, P<0.01), insulin (γ = 0.189, P = 0.047), PAI-1 (γ = 0.206, P<0.01), leptin (γ = 0.322, P<0.01), mean IMT (γ = 0.132, P = 0.042), and HOMA-IR (γ = 0.172, P = 0.045). After adjustment for age and gender, multiple regression analysis showed that serum CRP was significantly associated with leptin (β = 0.326, P = 0.01) and visceral adipose tissue (β = 0.265, P = 0.035). In conclusion, serum CRP level is significantly associated with obesity, especially the visceral adipose tissue, and serum leptin is another important independent factor associated with CRP in Korean type 2 diabetic patients.

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