Visceral fat thickness is associated with carotid atherosclerosis in peritoneal dialysis patients

Mi Jung Lee, Dong Ho Shin, Seung Jun Kim, Hyung Jung Oh, Dong Eun Yoo, Jwa Kyung Kim, Jung Tak Park, SeungHyeok Han, Shin-Wook Kang, Kyu Hun Choi, TaeHyun Yoo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Visceral fat has been known to associate with atherosclerosis, inflammation, and insulin resistance. However, the influence of visceral fat on cardiovascular disease (CVD) in peritoneal dialysis (PD) patients has never been elucidated. We investigated whether visceral fat thickness (VFT) has a predictive role in carotid atherosclerosis determined by carotid intima-media thickness (cIMT) in PD patients. A cross-sectional study was undertaken in 88 prevalent PD patients. BMI and waist circumference (WC) were measured as anthropometric indexes of obesity. VFT and subcutaneous fat thickness (SFT) were determined by sonographic measurement of abdominal fat. Carotid atherosclerosis was defined as increased cIMT (1.0 mm) or presence of plaque. Thirty-two (36.3%) patients had carotid atherosclerosis. Patients with carotid atherosclerosis showed significantly higher VFT, BMI, and WC. In univariate logistic analysis, BMI, WC, and VFT except SFT were significant risk factors of carotid atherosclerosis. However, multivariate analysis revealed VFT was an independent factor associated with carotid atherosclerosis after adjusting for demographic, biochemical parameters, and anthropometric indexes (per 1 mm increase, odds ratio (OR) = 2.294, 95% confidence interval: 1.048-5.021, P = 0.038). When the patients were divided into three groups according to VFT, log high sensitivity C-reactive protein (hs-CRP), and homeostasis model assessment-insulin resistance (HOMA IR) were both higher in the third tertile compared to other tertiles. In conclusion, VFT, not SFT, is independently associated with carotid atherosclerosis in PD patients. Therefore sonographic measurement of VFT could be useful to stratify the risk of cardiovascular disease in PD patients.

Original languageEnglish
Pages (from-to)1301-1307
Number of pages7
JournalObesity
Volume20
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

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Carotid Artery Diseases
Intra-Abdominal Fat
Peritoneal Dialysis
Subcutaneous Fat
Waist Circumference
Carotid Intima-Media Thickness
Insulin Resistance
Cardiovascular Diseases
Abdominal Fat
C-Reactive Protein
Atherosclerosis
Homeostasis
Multivariate Analysis
Obesity
Cross-Sectional Studies
Odds Ratio
Demography
Confidence Intervals
Inflammation

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Lee, Mi Jung ; Shin, Dong Ho ; Kim, Seung Jun ; Oh, Hyung Jung ; Yoo, Dong Eun ; Kim, Jwa Kyung ; Park, Jung Tak ; Han, SeungHyeok ; Kang, Shin-Wook ; Choi, Kyu Hun ; Yoo, TaeHyun. / Visceral fat thickness is associated with carotid atherosclerosis in peritoneal dialysis patients. In: Obesity. 2012 ; Vol. 20, No. 6. pp. 1301-1307.
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abstract = "Visceral fat has been known to associate with atherosclerosis, inflammation, and insulin resistance. However, the influence of visceral fat on cardiovascular disease (CVD) in peritoneal dialysis (PD) patients has never been elucidated. We investigated whether visceral fat thickness (VFT) has a predictive role in carotid atherosclerosis determined by carotid intima-media thickness (cIMT) in PD patients. A cross-sectional study was undertaken in 88 prevalent PD patients. BMI and waist circumference (WC) were measured as anthropometric indexes of obesity. VFT and subcutaneous fat thickness (SFT) were determined by sonographic measurement of abdominal fat. Carotid atherosclerosis was defined as increased cIMT (1.0 mm) or presence of plaque. Thirty-two (36.3{\%}) patients had carotid atherosclerosis. Patients with carotid atherosclerosis showed significantly higher VFT, BMI, and WC. In univariate logistic analysis, BMI, WC, and VFT except SFT were significant risk factors of carotid atherosclerosis. However, multivariate analysis revealed VFT was an independent factor associated with carotid atherosclerosis after adjusting for demographic, biochemical parameters, and anthropometric indexes (per 1 mm increase, odds ratio (OR) = 2.294, 95{\%} confidence interval: 1.048-5.021, P = 0.038). When the patients were divided into three groups according to VFT, log high sensitivity C-reactive protein (hs-CRP), and homeostasis model assessment-insulin resistance (HOMA IR) were both higher in the third tertile compared to other tertiles. In conclusion, VFT, not SFT, is independently associated with carotid atherosclerosis in PD patients. Therefore sonographic measurement of VFT could be useful to stratify the risk of cardiovascular disease in PD patients.",
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Lee, MJ, Shin, DH, Kim, SJ, Oh, HJ, Yoo, DE, Kim, JK, Park, JT, Han, S, Kang, S-W, Choi, KH & Yoo, T 2012, 'Visceral fat thickness is associated with carotid atherosclerosis in peritoneal dialysis patients', Obesity, vol. 20, no. 6, pp. 1301-1307. https://doi.org/10.1038/oby.2011.245

Visceral fat thickness is associated with carotid atherosclerosis in peritoneal dialysis patients. / Lee, Mi Jung; Shin, Dong Ho; Kim, Seung Jun; Oh, Hyung Jung; Yoo, Dong Eun; Kim, Jwa Kyung; Park, Jung Tak; Han, SeungHyeok; Kang, Shin-Wook; Choi, Kyu Hun; Yoo, TaeHyun.

In: Obesity, Vol. 20, No. 6, 01.06.2012, p. 1301-1307.

Research output: Contribution to journalArticle

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T1 - Visceral fat thickness is associated with carotid atherosclerosis in peritoneal dialysis patients

AU - Lee, Mi Jung

AU - Shin, Dong Ho

AU - Kim, Seung Jun

AU - Oh, Hyung Jung

AU - Yoo, Dong Eun

AU - Kim, Jwa Kyung

AU - Park, Jung Tak

AU - Han, SeungHyeok

AU - Kang, Shin-Wook

AU - Choi, Kyu Hun

AU - Yoo, TaeHyun

PY - 2012/6/1

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N2 - Visceral fat has been known to associate with atherosclerosis, inflammation, and insulin resistance. However, the influence of visceral fat on cardiovascular disease (CVD) in peritoneal dialysis (PD) patients has never been elucidated. We investigated whether visceral fat thickness (VFT) has a predictive role in carotid atherosclerosis determined by carotid intima-media thickness (cIMT) in PD patients. A cross-sectional study was undertaken in 88 prevalent PD patients. BMI and waist circumference (WC) were measured as anthropometric indexes of obesity. VFT and subcutaneous fat thickness (SFT) were determined by sonographic measurement of abdominal fat. Carotid atherosclerosis was defined as increased cIMT (1.0 mm) or presence of plaque. Thirty-two (36.3%) patients had carotid atherosclerosis. Patients with carotid atherosclerosis showed significantly higher VFT, BMI, and WC. In univariate logistic analysis, BMI, WC, and VFT except SFT were significant risk factors of carotid atherosclerosis. However, multivariate analysis revealed VFT was an independent factor associated with carotid atherosclerosis after adjusting for demographic, biochemical parameters, and anthropometric indexes (per 1 mm increase, odds ratio (OR) = 2.294, 95% confidence interval: 1.048-5.021, P = 0.038). When the patients were divided into three groups according to VFT, log high sensitivity C-reactive protein (hs-CRP), and homeostasis model assessment-insulin resistance (HOMA IR) were both higher in the third tertile compared to other tertiles. In conclusion, VFT, not SFT, is independently associated with carotid atherosclerosis in PD patients. Therefore sonographic measurement of VFT could be useful to stratify the risk of cardiovascular disease in PD patients.

AB - Visceral fat has been known to associate with atherosclerosis, inflammation, and insulin resistance. However, the influence of visceral fat on cardiovascular disease (CVD) in peritoneal dialysis (PD) patients has never been elucidated. We investigated whether visceral fat thickness (VFT) has a predictive role in carotid atherosclerosis determined by carotid intima-media thickness (cIMT) in PD patients. A cross-sectional study was undertaken in 88 prevalent PD patients. BMI and waist circumference (WC) were measured as anthropometric indexes of obesity. VFT and subcutaneous fat thickness (SFT) were determined by sonographic measurement of abdominal fat. Carotid atherosclerosis was defined as increased cIMT (1.0 mm) or presence of plaque. Thirty-two (36.3%) patients had carotid atherosclerosis. Patients with carotid atherosclerosis showed significantly higher VFT, BMI, and WC. In univariate logistic analysis, BMI, WC, and VFT except SFT were significant risk factors of carotid atherosclerosis. However, multivariate analysis revealed VFT was an independent factor associated with carotid atherosclerosis after adjusting for demographic, biochemical parameters, and anthropometric indexes (per 1 mm increase, odds ratio (OR) = 2.294, 95% confidence interval: 1.048-5.021, P = 0.038). When the patients were divided into three groups according to VFT, log high sensitivity C-reactive protein (hs-CRP), and homeostasis model assessment-insulin resistance (HOMA IR) were both higher in the third tertile compared to other tertiles. In conclusion, VFT, not SFT, is independently associated with carotid atherosclerosis in PD patients. Therefore sonographic measurement of VFT could be useful to stratify the risk of cardiovascular disease in PD patients.

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