Previous studies have shown that maturation of the white matter in terms of its relative signal intensity changes on MRI is almost complete at 2-3 years of age. We hypothesized that quantitative analysis may show maturation of the white matter during childhood and adolescence. In the present study we performed multi-echo T2 relaxometry in 33 healthy subjects (girls, 15; boys, 18) aged 3-15 years. T2 relaxation times of the genu and splenium were measured. In healthy subjects, the T2 relaxation times were significantly correlated with age in both girls (r = 0.611, p = .016) and boys (r = 0.721, p = .001) in the splenium, but not in the genu (p > .05). To further confirm genu-to-splenium signal intensity ratio changes, a total of 389 brain MRIs were retrospectively selected from the patients who had normal results (189 girls/women, 200 boys/men; age range, 3-20 years). The genu-to-splenium signal intensity ratio was obtained from the T2-weighted images. In patients with normal MRI, the genu-to-splenium signal intensity ratio was significantly decreased with age (p < .001) by 16 years. The T2 relaxation times gradually increase in the splenium during childhood and adolescence, suggestive of maturation.
|Number of pages||6|
|Journal||International Journal of Developmental Neuroscience|
|Publication status||Published - 2007 Oct|
Bibliographical noteFunding Information:
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV07-0002) (Hae-Jeong Park).
This work was supported by a faculty research grant of Yonsei University College of Medicine for 2005 (No. 2005-0103), a Yonsei University Research Fund of 2005, and a Schering Radiological Research Fund of the Korean Radiological Society of 2005 (Eung Y. Kim).
All Science Journal Classification (ASJC) codes
- Developmental Neuroscience
- Developmental Biology