Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants

Young Eun Kwon, Hyunwook Kim, Hyung Jung Oh, Jung Tak Park, SeungHyeok Han, Dong Ryeol Ryu, TaeHyun Yoo, Shin-Wook Kang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Vitamin D deficiency is frequently found in patients with renal transplants (RTxs). Because vitamin D plays indispensable roles in the immune system, there may be an association between vitamin D deficiency and infection in these patients, but this has not been fully elucidated. Therefore, this study investigated the impact of pre-RTx vitamin D deficiency on urinary tract infection (UTI) development after RTx. We measured 25-hydroxyvitamin D3 (25(OH)D3) levels in 410 patients 2 weeks before they underwent RTx. Vitamin D deficiency was defined as 25(OH)D3 <10ng/mL. The primary outcome was UTI occurrence after RTx. Cox proportional hazard analysis determined whether vitamin D deficiency was independently associated with UTI. The mean 25(OH)D3 level was 12.8±6.9ng/mL, and 171 patients (41.7%) were vitamin D deficient. During a median follow-up duration of 7.3 years, the UTI incidence was significantly higher in vitamin D-deficient patients (52 patients, 30.4%) compared with vitamin D-nondeficient patients (40 patients, 16.7%) (P=0.001). Moreover, multivariate Cox proportional hazard analysis showed that vitamin D deficiency was an independent predictor of UTI after RTx (hazard ratio 1.81, 95% confidence interval 1.11-2.97, P=0.02). Vitamin D deficiency was an independent risk factor for UTI after RTx; hence, determining 25(OH)D3 levels might help to predict infectious complications after RTx.

Original languageEnglish
Pages (from-to)e594
JournalMedicine (United States)
Volume94
Issue number9
DOIs
Publication statusPublished - 2015 Mar 7

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Vitamin D Deficiency
Urinary Tract Infections
Transplants
Kidney
Vitamin D
Calcifediol
Immune System
Confidence Intervals
Incidence
Infection

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kwon, Young Eun ; Kim, Hyunwook ; Oh, Hyung Jung ; Park, Jung Tak ; Han, SeungHyeok ; Ryu, Dong Ryeol ; Yoo, TaeHyun ; Kang, Shin-Wook. / Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants. In: Medicine (United States). 2015 ; Vol. 94, No. 9. pp. e594.
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abstract = "Vitamin D deficiency is frequently found in patients with renal transplants (RTxs). Because vitamin D plays indispensable roles in the immune system, there may be an association between vitamin D deficiency and infection in these patients, but this has not been fully elucidated. Therefore, this study investigated the impact of pre-RTx vitamin D deficiency on urinary tract infection (UTI) development after RTx. We measured 25-hydroxyvitamin D3 (25(OH)D3) levels in 410 patients 2 weeks before they underwent RTx. Vitamin D deficiency was defined as 25(OH)D3 <10ng/mL. The primary outcome was UTI occurrence after RTx. Cox proportional hazard analysis determined whether vitamin D deficiency was independently associated with UTI. The mean 25(OH)D3 level was 12.8±6.9ng/mL, and 171 patients (41.7{\%}) were vitamin D deficient. During a median follow-up duration of 7.3 years, the UTI incidence was significantly higher in vitamin D-deficient patients (52 patients, 30.4{\%}) compared with vitamin D-nondeficient patients (40 patients, 16.7{\%}) (P=0.001). Moreover, multivariate Cox proportional hazard analysis showed that vitamin D deficiency was an independent predictor of UTI after RTx (hazard ratio 1.81, 95{\%} confidence interval 1.11-2.97, P=0.02). Vitamin D deficiency was an independent risk factor for UTI after RTx; hence, determining 25(OH)D3 levels might help to predict infectious complications after RTx.",
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Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants. / Kwon, Young Eun; Kim, Hyunwook; Oh, Hyung Jung; Park, Jung Tak; Han, SeungHyeok; Ryu, Dong Ryeol; Yoo, TaeHyun; Kang, Shin-Wook.

In: Medicine (United States), Vol. 94, No. 9, 07.03.2015, p. e594.

Research output: Contribution to journalArticle

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AU - Kwon, Young Eun

AU - Kim, Hyunwook

AU - Oh, Hyung Jung

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AU - Ryu, Dong Ryeol

AU - Yoo, TaeHyun

AU - Kang, Shin-Wook

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