Vitamin E supplementation alters HDL-cholesterol concentration and paraoxonase activity in rabbits fed high-cholesterol diet: Comparison with probucol

Seon Min Jeon, Yong Bok Park, Oh Shin Kwon, Tae Lin Huh, Won Ha Lee, Kyung Min Do, Taesun Park, Myung Sook Choi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Vitamin E and probucol are well-known antioxidants that prevent cells from the oxidative stress, which is a risk factor of atherosclerosis. Male rabbits were fed either 0.03% vitamin E or 0.05% probucol in a 0.5% high-cholesterol (HC) diet for 8 weeks. Vitamin E and probucol significantly suppressed an increase in plasma total-cholesterol (total-C) and low-density lipoprotein cholesterol compared to HC-control group. However, plasma high-density lipoprotein-cholesterol (HDL-C) and HDL-C/total-C ratio levels and plasma paraoxonase activity were only significantly higher in vitamin E group after 8 weeks. Hepatic ACAT activity was significantly lower in both vitamin E and probucol groups than in HC-control group, while HMG-CoA reductase activity was the highest only in the probucol group. Total fecal sterol content was significantly higher in probucol and vitamin E groups than in the two control groups. Some atherogenic signs were discovered in the aortic fatty streak of HC-control group, yet not in other groups. Hepatic mRNA expressions of apo B-100 and apo C-III were significantly lower in probucol group than in other groups. Vitamin E supplementation was found to alter the plasma HDL-C-related factors; meanwhile, probucol supplementation was very effective in enhancing cholesterol metabolism, except for a negative effect that reduced plasma HDL-C concentration.

Original languageEnglish
Pages (from-to)336-346
Number of pages11
JournalJournal of Biochemical and Molecular Toxicology
Volume19
Issue number5
DOIs
Publication statusPublished - 2005 Nov 28

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Probucol
Aryldialkylphosphatase
Nutrition
Vitamin E
HDL Cholesterol
Cholesterol
Diet
Rabbits
Plasmas
Control Groups
Apolipoprotein C-III
Apolipoprotein B-100
Hydroxymethylglutaryl CoA Reductases
Oxidative stress
Liver
Sterols
Metabolism
LDL Cholesterol
Atherosclerosis
Oxidative Stress

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Jeon, Seon Min ; Park, Yong Bok ; Kwon, Oh Shin ; Huh, Tae Lin ; Lee, Won Ha ; Do, Kyung Min ; Park, Taesun ; Choi, Myung Sook. / Vitamin E supplementation alters HDL-cholesterol concentration and paraoxonase activity in rabbits fed high-cholesterol diet : Comparison with probucol. In: Journal of Biochemical and Molecular Toxicology. 2005 ; Vol. 19, No. 5. pp. 336-346.
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Vitamin E supplementation alters HDL-cholesterol concentration and paraoxonase activity in rabbits fed high-cholesterol diet : Comparison with probucol. / Jeon, Seon Min; Park, Yong Bok; Kwon, Oh Shin; Huh, Tae Lin; Lee, Won Ha; Do, Kyung Min; Park, Taesun; Choi, Myung Sook.

In: Journal of Biochemical and Molecular Toxicology, Vol. 19, No. 5, 28.11.2005, p. 336-346.

Research output: Contribution to journalArticle

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T1 - Vitamin E supplementation alters HDL-cholesterol concentration and paraoxonase activity in rabbits fed high-cholesterol diet

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AU - Jeon, Seon Min

AU - Park, Yong Bok

AU - Kwon, Oh Shin

AU - Huh, Tae Lin

AU - Lee, Won Ha

AU - Do, Kyung Min

AU - Park, Taesun

AU - Choi, Myung Sook

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N2 - Vitamin E and probucol are well-known antioxidants that prevent cells from the oxidative stress, which is a risk factor of atherosclerosis. Male rabbits were fed either 0.03% vitamin E or 0.05% probucol in a 0.5% high-cholesterol (HC) diet for 8 weeks. Vitamin E and probucol significantly suppressed an increase in plasma total-cholesterol (total-C) and low-density lipoprotein cholesterol compared to HC-control group. However, plasma high-density lipoprotein-cholesterol (HDL-C) and HDL-C/total-C ratio levels and plasma paraoxonase activity were only significantly higher in vitamin E group after 8 weeks. Hepatic ACAT activity was significantly lower in both vitamin E and probucol groups than in HC-control group, while HMG-CoA reductase activity was the highest only in the probucol group. Total fecal sterol content was significantly higher in probucol and vitamin E groups than in the two control groups. Some atherogenic signs were discovered in the aortic fatty streak of HC-control group, yet not in other groups. Hepatic mRNA expressions of apo B-100 and apo C-III were significantly lower in probucol group than in other groups. Vitamin E supplementation was found to alter the plasma HDL-C-related factors; meanwhile, probucol supplementation was very effective in enhancing cholesterol metabolism, except for a negative effect that reduced plasma HDL-C concentration.

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