Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours: an initial experience

Suyon Chang, Jin Hur, Dong Jin Im, Young Joo Suh, Yoo Jin Hong, Hye Jeong Lee, Youngjin Kim, Kyunghwa Han, Dae Joon Kim, Chang Young Lee, Ha Young Shin, Byoung Wook Choi

Research output: Contribution to journalArticle

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Abstract

Objectives: To investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas. Materials: Our institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis. Results: Of the 37 thymic tumours, 23 (62.2 %) were low-risk thymomas, five (13.5 %) were high-risk thymomas and nine (24.3 %) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively). Conclusion: DECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning. Key Points: • IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas • IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas • Dual-energy CT helps differentiate among thymic epithelial tumours.

Original languageEnglish
Pages (from-to)1992-2001
Number of pages10
JournalEuropean Radiology
Volume27
Issue number5
DOIs
Publication statusPublished - 2017 May 1

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Thymoma
Tomography
Iodine
Thymic epithelial tumor
Thymus Neoplasms
Research Ethics Committees
Informed Consent

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Chang, Suyon ; Hur, Jin ; Im, Dong Jin ; Suh, Young Joo ; Hong, Yoo Jin ; Lee, Hye Jeong ; Kim, Youngjin ; Han, Kyunghwa ; Kim, Dae Joon ; Lee, Chang Young ; Shin, Ha Young ; Choi, Byoung Wook. / Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours : an initial experience. In: European Radiology. 2017 ; Vol. 27, No. 5. pp. 1992-2001.
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title = "Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours: an initial experience",
abstract = "Objectives: To investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas. Materials: Our institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis. Results: Of the 37 thymic tumours, 23 (62.2 {\%}) were low-risk thymomas, five (13.5 {\%}) were high-risk thymomas and nine (24.3 {\%}) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively). Conclusion: DECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning. Key Points: • IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas • IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas • Dual-energy CT helps differentiate among thymic epithelial tumours.",
author = "Suyon Chang and Jin Hur and Im, {Dong Jin} and Suh, {Young Joo} and Hong, {Yoo Jin} and Lee, {Hye Jeong} and Youngjin Kim and Kyunghwa Han and Kim, {Dae Joon} and Lee, {Chang Young} and Shin, {Ha Young} and Choi, {Byoung Wook}",
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Chang, S, Hur, J, Im, DJ, Suh, YJ, Hong, YJ, Lee, HJ, Kim, Y, Han, K, Kim, DJ, Lee, CY, Shin, HY & Choi, BW 2017, 'Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours: an initial experience', European Radiology, vol. 27, no. 5, pp. 1992-2001. https://doi.org/10.1007/s00330-016-4542-9

Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours : an initial experience. / Chang, Suyon; Hur, Jin; Im, Dong Jin; Suh, Young Joo; Hong, Yoo Jin; Lee, Hye Jeong; Kim, Youngjin; Han, Kyunghwa; Kim, Dae Joon; Lee, Chang Young; Shin, Ha Young; Choi, Byoung Wook.

In: European Radiology, Vol. 27, No. 5, 01.05.2017, p. 1992-2001.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours

T2 - an initial experience

AU - Chang, Suyon

AU - Hur, Jin

AU - Im, Dong Jin

AU - Suh, Young Joo

AU - Hong, Yoo Jin

AU - Lee, Hye Jeong

AU - Kim, Youngjin

AU - Han, Kyunghwa

AU - Kim, Dae Joon

AU - Lee, Chang Young

AU - Shin, Ha Young

AU - Choi, Byoung Wook

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objectives: To investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas. Materials: Our institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis. Results: Of the 37 thymic tumours, 23 (62.2 %) were low-risk thymomas, five (13.5 %) were high-risk thymomas and nine (24.3 %) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively). Conclusion: DECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning. Key Points: • IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas • IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas • Dual-energy CT helps differentiate among thymic epithelial tumours.

AB - Objectives: To investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas. Materials: Our institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis. Results: Of the 37 thymic tumours, 23 (62.2 %) were low-risk thymomas, five (13.5 %) were high-risk thymomas and nine (24.3 %) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively). Conclusion: DECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning. Key Points: • IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas • IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas • Dual-energy CT helps differentiate among thymic epithelial tumours.

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