Abstract
Objective: The thalamus, which consists of multiple subnuclei, has been of particular interest in the study of schizophrenia. This study aimed to identify abnormalities in the connectivity-based subregions of the thalamus in patients with schizophrenia. Methods: Thalamic volume was measured by a manual tracing on superimposed images of T1-weighted and diffusion tensor images in 30 patients with schizophrenia and 22 normal volunteers. Cortical regional volumes automatically measured by a surface-based approach and thalamic subregional volumes measured by a connectivity-based technique were compared between the two groups and their correlations between the connected regions were calculated in each group. Results: Volume reduction was observed in the bilateral orbitofrontal cortices and the left cingulate gyrus on the cortical side, whereas in subregions connected to the right orbitofrontal cortex and bilateral parietal cortices on the thalamic side. Significant volumetric correlations were identified between the right dorsal prefrontal cortex and its related thalamic subregion and between the left parietal cortex and its related thalamic subregion only in the normal group. Conclusions: Our results suggest that patients with schizophrenia have a structural deficit in the corticothalamic systems, especially in the orbitofrontal-thalamic system. Our findings may present evidence of corticothalamic connection problems in schizophrenia.
| Original language | English |
|---|---|
| Pages (from-to) | 226-235 |
| Number of pages | 10 |
| Journal | Schizophrenia Research |
| Volume | 97 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 2007 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry
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Volumetric abnormalities in connectivity-based subregions of the thalamus in patients with chronic schizophrenia. / Kim, Jae Jin; Kim, Dae Jin; Kim, Tae Gyun; Seok, Jeong Ho; Chun, Ji Won; Oh, Maeng Keun; Park, Hae Jeong.
In: Schizophrenia Research, Vol. 97, No. 1-3, 01.12.2007, p. 226-235.Research output: Contribution to journal › Article
TY - JOUR
T1 - Volumetric abnormalities in connectivity-based subregions of the thalamus in patients with chronic schizophrenia
AU - Kim, Jae Jin
AU - Kim, Dae Jin
AU - Kim, Tae Gyun
AU - Seok, Jeong Ho
AU - Chun, Ji Won
AU - Oh, Maeng Keun
AU - Park, Hae Jeong
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Objective: The thalamus, which consists of multiple subnuclei, has been of particular interest in the study of schizophrenia. This study aimed to identify abnormalities in the connectivity-based subregions of the thalamus in patients with schizophrenia. Methods: Thalamic volume was measured by a manual tracing on superimposed images of T1-weighted and diffusion tensor images in 30 patients with schizophrenia and 22 normal volunteers. Cortical regional volumes automatically measured by a surface-based approach and thalamic subregional volumes measured by a connectivity-based technique were compared between the two groups and their correlations between the connected regions were calculated in each group. Results: Volume reduction was observed in the bilateral orbitofrontal cortices and the left cingulate gyrus on the cortical side, whereas in subregions connected to the right orbitofrontal cortex and bilateral parietal cortices on the thalamic side. Significant volumetric correlations were identified between the right dorsal prefrontal cortex and its related thalamic subregion and between the left parietal cortex and its related thalamic subregion only in the normal group. Conclusions: Our results suggest that patients with schizophrenia have a structural deficit in the corticothalamic systems, especially in the orbitofrontal-thalamic system. Our findings may present evidence of corticothalamic connection problems in schizophrenia.
AB - Objective: The thalamus, which consists of multiple subnuclei, has been of particular interest in the study of schizophrenia. This study aimed to identify abnormalities in the connectivity-based subregions of the thalamus in patients with schizophrenia. Methods: Thalamic volume was measured by a manual tracing on superimposed images of T1-weighted and diffusion tensor images in 30 patients with schizophrenia and 22 normal volunteers. Cortical regional volumes automatically measured by a surface-based approach and thalamic subregional volumes measured by a connectivity-based technique were compared between the two groups and their correlations between the connected regions were calculated in each group. Results: Volume reduction was observed in the bilateral orbitofrontal cortices and the left cingulate gyrus on the cortical side, whereas in subregions connected to the right orbitofrontal cortex and bilateral parietal cortices on the thalamic side. Significant volumetric correlations were identified between the right dorsal prefrontal cortex and its related thalamic subregion and between the left parietal cortex and its related thalamic subregion only in the normal group. Conclusions: Our results suggest that patients with schizophrenia have a structural deficit in the corticothalamic systems, especially in the orbitofrontal-thalamic system. Our findings may present evidence of corticothalamic connection problems in schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=36048943944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36048943944&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2007.09.007
DO - 10.1016/j.schres.2007.09.007
M3 - Article
C2 - 17913465
AN - SCOPUS:36048943944
VL - 97
SP - 226
EP - 235
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-3
ER -