Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status

Seo Hee Choi, Tae Min Jung, Ji E. Lee, Seung Koo Lee, Young H. Sohn, Phil Hyu Lee

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Abstract

The cholinergic system arising from the substantia innominata (SI) of the basal forebrain has an important role in the cognitive functions of Parkinson's disease (PD). We performed magnetic resonance imaging based volumetric analysis to evaluate the SI volume in patients with PD-intact cognition (PD-IC), PD-mild cognitive impairment (PD-MCI), and PD dementia (PDD). The mean normalized SI volume was significantly decreased in patients with PD-IC (1.54 ± 0.12, p < 0.001), PD-MCI (1.49 ± 0.12, p < 0.001), and PDD (1.39 ± 0.12, p < 0.001) compared with that of control subjects (1.68 ± 0.11). The normalized SI volume did not differ between patients with PD-IC and PD-MCI; however, the normalized SI volume was significantly decreased in patients with PDD compared with that in those with PD-IC (p < 0.001) or PD-MCI (p = 0.016). The normalized SI volume was significantly correlated with general cognitive status (r = 0.51, p < 0.001) as well as with performance in each cognitive subdomain, with a particularly significant independent association with attention (β = 0.33, p = 0.003) and object naming (β = 0.26, p = 0.017). The present study demonstrated that the SI volume in PD differs depending on cognitive status and is significantly correlated with cognitive performance.

Original languageEnglish
Pages (from-to)1265-1272
Number of pages8
JournalNeurobiology of Aging
Volume33
Issue number7
DOIs
Publication statusPublished - 2012 Jul 1

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Substantia Innominata
Parkinson Disease
Dementia
Cognition
Cholinergic Agents

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Choi, Seo Hee ; Jung, Tae Min ; Lee, Ji E. ; Lee, Seung Koo ; Sohn, Young H. ; Lee, Phil Hyu. / Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status. In: Neurobiology of Aging. 2012 ; Vol. 33, No. 7. pp. 1265-1272.
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Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status. / Choi, Seo Hee; Jung, Tae Min; Lee, Ji E.; Lee, Seung Koo; Sohn, Young H.; Lee, Phil Hyu.

In: Neurobiology of Aging, Vol. 33, No. 7, 01.07.2012, p. 1265-1272.

Research output: Contribution to journalArticle

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