Volumetric investigation of the frontal-subcortical circuitry in patients with obsessive-compulsive disorder

Do Hyung Kang, Jae Jin Kim, Jung Seok Choi, Young Il Kim, Chi Won Kim, Tak Youn, Moon Hee Han, Kee Hyun Chang, Jun Soo Kwon

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The pathophysiology of obsessive-compulsive disorder (OCD) is thought to involve disturbance of the frontal-subcortical circuitry. To investigate the morphological characteristics of this circuitry, we examined the volume of the orbitofrontal cortex, anterior cingulate, thalamus, caudate, and the putamen in 36 age- and sex-matched OCD patients and normal control subjects using three-dimensional magnetic resonance (MR) brain imaging. The left orbitofrontal volumes were found to be significantly smaller in the OCD patients and showed significant negative correlations with obsessive-compulsive symptom severity. These findings suggest that a structural abnormality of this brain region is implicated in the pathophysiology of OCD.

Original languageEnglish
Pages (from-to)342-349
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume16
Issue number3
DOIs
Publication statusPublished - 2004 Jan 1

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Obsessive-Compulsive Disorder
Putamen
Gyrus Cinguli
Prefrontal Cortex
Thalamus
Neuroimaging
Magnetic Resonance Imaging
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Kang, Do Hyung ; Kim, Jae Jin ; Choi, Jung Seok ; Kim, Young Il ; Kim, Chi Won ; Youn, Tak ; Han, Moon Hee ; Chang, Kee Hyun ; Kwon, Jun Soo. / Volumetric investigation of the frontal-subcortical circuitry in patients with obsessive-compulsive disorder. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2004 ; Vol. 16, No. 3. pp. 342-349.
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Volumetric investigation of the frontal-subcortical circuitry in patients with obsessive-compulsive disorder. / Kang, Do Hyung; Kim, Jae Jin; Choi, Jung Seok; Kim, Young Il; Kim, Chi Won; Youn, Tak; Han, Moon Hee; Chang, Kee Hyun; Kwon, Jun Soo.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 16, No. 3, 01.01.2004, p. 342-349.

Research output: Contribution to journalArticle

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