Volumetric investigation of the frontal-subcortical circuitry in patients with obsessive-compulsive disorder

Do Hyung Kang, Jae Jin Kim, Jung Seok Choi, Young Il Kim, Chi Won Kim, Tak Youn, Moon Hee Han, Kee Hyun Chang, Jun Soo Kwon

Research output: Contribution to journalArticle

77 Citations (Scopus)


The pathophysiology of obsessive-compulsive disorder (OCD) is thought to involve disturbance of the frontal-subcortical circuitry. To investigate the morphological characteristics of this circuitry, we examined the volume of the orbitofrontal cortex, anterior cingulate, thalamus, caudate, and the putamen in 36 age- and sex-matched OCD patients and normal control subjects using three-dimensional magnetic resonance (MR) brain imaging. The left orbitofrontal volumes were found to be significantly smaller in the OCD patients and showed significant negative correlations with obsessive-compulsive symptom severity. These findings suggest that a structural abnormality of this brain region is implicated in the pathophysiology of OCD.

Original languageEnglish
Pages (from-to)342-349
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number3
Publication statusPublished - 2004 Jan 1


All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health

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