Abstract
Recently, deep brain stimulation (DBS) is widely used in various types of neurodegenerative disorders for minimal invasiveness and safety of the procedure. Deep brain stimulation is consistently applied for the treatment of patients with neuropathic pain even though the success rate is not as high as other neurodegenerative disorders. Furthermore, it is also unclear how DBS improves neuropathic pain. In this study, we investigated the role of DBS following the stimulation parameter for analgesic effect on mechanical allodynia and cold allodynia in neuropathic pain rats. We used a sciatic nerve injury model to induce neuropathic pain, and observed responses to mechanical and cold stimulation by the von Frey test and acetone test, respectively. We classified the rats into four groups: naïve (naïve, n = 10), naïve + DBS (N + DBS, n = 10), neuropathic pain (NP, n = 10), and neuropathic pain + DBS (NP + DBS, n = 10). We inserted the DBS electrode into the ventral posterolateral nucleus (VPL) into the rats (VPL-DBS). The score for mechanical allodynia was significantly decreased in NP + DBS group (p<0.01). However, the score for cold allodynia did not significantly drop in any groups including NP + DBS group (p>0.05). In this study, we found that the electrical stimulation of the VPL works more effectively with mechanical allodynia than cold one, and pain signal induced by mechanical stimulus and cold stimulus may be processed through different pathways in the brain.
| Original language | English |
|---|---|
| Pages (from-to) | 1265-1270 |
| Number of pages | 6 |
| Journal | Neurological Sciences |
| Volume | 33 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2012 Mar 23 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Dermatology
- Clinical Neurology
- Psychiatry and Mental health
Cite this
}
VPL-DBS on neuropathic pain rat model is effective in mechanical allodynia than cold allodynia. / Kim, Jaehyung; Kim, Jinhyung; Min, Kyou Sik; Lee, Sung Eun; Kim, Sung June; Chang, JinWoo.
In: Neurological Sciences, Vol. 33, No. 6, 23.03.2012, p. 1265-1270.Research output: Contribution to journal › Article
TY - JOUR
T1 - VPL-DBS on neuropathic pain rat model is effective in mechanical allodynia than cold allodynia
AU - Kim, Jaehyung
AU - Kim, Jinhyung
AU - Min, Kyou Sik
AU - Lee, Sung Eun
AU - Kim, Sung June
AU - Chang, JinWoo
PY - 2012/3/23
Y1 - 2012/3/23
N2 - Recently, deep brain stimulation (DBS) is widely used in various types of neurodegenerative disorders for minimal invasiveness and safety of the procedure. Deep brain stimulation is consistently applied for the treatment of patients with neuropathic pain even though the success rate is not as high as other neurodegenerative disorders. Furthermore, it is also unclear how DBS improves neuropathic pain. In this study, we investigated the role of DBS following the stimulation parameter for analgesic effect on mechanical allodynia and cold allodynia in neuropathic pain rats. We used a sciatic nerve injury model to induce neuropathic pain, and observed responses to mechanical and cold stimulation by the von Frey test and acetone test, respectively. We classified the rats into four groups: naïve (naïve, n = 10), naïve + DBS (N + DBS, n = 10), neuropathic pain (NP, n = 10), and neuropathic pain + DBS (NP + DBS, n = 10). We inserted the DBS electrode into the ventral posterolateral nucleus (VPL) into the rats (VPL-DBS). The score for mechanical allodynia was significantly decreased in NP + DBS group (p<0.01). However, the score for cold allodynia did not significantly drop in any groups including NP + DBS group (p>0.05). In this study, we found that the electrical stimulation of the VPL works more effectively with mechanical allodynia than cold one, and pain signal induced by mechanical stimulus and cold stimulus may be processed through different pathways in the brain.
AB - Recently, deep brain stimulation (DBS) is widely used in various types of neurodegenerative disorders for minimal invasiveness and safety of the procedure. Deep brain stimulation is consistently applied for the treatment of patients with neuropathic pain even though the success rate is not as high as other neurodegenerative disorders. Furthermore, it is also unclear how DBS improves neuropathic pain. In this study, we investigated the role of DBS following the stimulation parameter for analgesic effect on mechanical allodynia and cold allodynia in neuropathic pain rats. We used a sciatic nerve injury model to induce neuropathic pain, and observed responses to mechanical and cold stimulation by the von Frey test and acetone test, respectively. We classified the rats into four groups: naïve (naïve, n = 10), naïve + DBS (N + DBS, n = 10), neuropathic pain (NP, n = 10), and neuropathic pain + DBS (NP + DBS, n = 10). We inserted the DBS electrode into the ventral posterolateral nucleus (VPL) into the rats (VPL-DBS). The score for mechanical allodynia was significantly decreased in NP + DBS group (p<0.01). However, the score for cold allodynia did not significantly drop in any groups including NP + DBS group (p>0.05). In this study, we found that the electrical stimulation of the VPL works more effectively with mechanical allodynia than cold one, and pain signal induced by mechanical stimulus and cold stimulus may be processed through different pathways in the brain.
UR - http://www.scopus.com/inward/record.url?scp=84883510586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883510586&partnerID=8YFLogxK
U2 - 10.1007/s10072-012-1097-7
DO - 10.1007/s10072-012-1097-7
M3 - Article
C2 - 22562402
AN - SCOPUS:84883510586
VL - 33
SP - 1265
EP - 1270
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 6
ER -