VPL-DBS on neuropathic pain rat model is effective in mechanical allodynia than cold allodynia

Jaehyung Kim, Jinhyung Kim, Kyou Sik Min, Sung Eun Lee, Sung June Kim, JinWoo Chang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Recently, deep brain stimulation (DBS) is widely used in various types of neurodegenerative disorders for minimal invasiveness and safety of the procedure. Deep brain stimulation is consistently applied for the treatment of patients with neuropathic pain even though the success rate is not as high as other neurodegenerative disorders. Furthermore, it is also unclear how DBS improves neuropathic pain. In this study, we investigated the role of DBS following the stimulation parameter for analgesic effect on mechanical allodynia and cold allodynia in neuropathic pain rats. We used a sciatic nerve injury model to induce neuropathic pain, and observed responses to mechanical and cold stimulation by the von Frey test and acetone test, respectively. We classified the rats into four groups: naïve (naïve, n = 10), naïve + DBS (N + DBS, n = 10), neuropathic pain (NP, n = 10), and neuropathic pain + DBS (NP + DBS, n = 10). We inserted the DBS electrode into the ventral posterolateral nucleus (VPL) into the rats (VPL-DBS). The score for mechanical allodynia was significantly decreased in NP + DBS group (p<0.01). However, the score for cold allodynia did not significantly drop in any groups including NP + DBS group (p>0.05). In this study, we found that the electrical stimulation of the VPL works more effectively with mechanical allodynia than cold one, and pain signal induced by mechanical stimulus and cold stimulus may be processed through different pathways in the brain.

Original languageEnglish
Pages (from-to)1265-1270
Number of pages6
JournalNeurological Sciences
Volume33
Issue number6
DOIs
Publication statusPublished - 2012 Mar 23

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Ventral Thalamic Nuclei
Deep Brain Stimulation
Hyperalgesia
Neuralgia
Neurodegenerative Diseases
Sciatic Nerve
Acetone
Electric Stimulation
Analgesics
Electrodes

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Kim, Jaehyung ; Kim, Jinhyung ; Min, Kyou Sik ; Lee, Sung Eun ; Kim, Sung June ; Chang, JinWoo. / VPL-DBS on neuropathic pain rat model is effective in mechanical allodynia than cold allodynia. In: Neurological Sciences. 2012 ; Vol. 33, No. 6. pp. 1265-1270.
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VPL-DBS on neuropathic pain rat model is effective in mechanical allodynia than cold allodynia. / Kim, Jaehyung; Kim, Jinhyung; Min, Kyou Sik; Lee, Sung Eun; Kim, Sung June; Chang, JinWoo.

In: Neurological Sciences, Vol. 33, No. 6, 23.03.2012, p. 1265-1270.

Research output: Contribution to journalArticle

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