Abstract
There has been controversy surrounding Waldeyer's ring (WR), especially focused on the question of whether it should be regarded as a nodal or an extranodal site. We conducted retrospective analyses of marginal zone B cell lymphomas involving WR (WR-MZLs) to observe their clinical features and prognosis, with specific regard to the nodal-or-extranodal question. A total of 52 patients with histological diagnosis of WR-MZL were retrospectively analyzed. The most common involvement site was the tonsil (40.4 %). Ann Arbor stage III/VI disease was present in 48.1 % (25 of 52). The response rate of the 27 stage I/II patients was 88.9 %, with 21 complete remissions and three partial remissions. The median time to progression (TTP) was 3.7 years (95 % CI 2.5-4.9 years). The estimated 5-year TTP and overall survival rates were 39.4 and 90.5 %, respectively. In a comparison with the historical data regarding extra-WR MALT lymphoma and nodal MZL (N-MZL), MALT lymphoma showed better TTP results than did WR-MZL and N-MZL (P\0.001).
| Original language | English |
|---|---|
| Pages (from-to) | 631-637 |
| Number of pages | 7 |
| Journal | International Journal of Hematology |
| Volume | 96 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 Nov 1 |
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All Science Journal Classification (ASJC) codes
- Hematology
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Waldeyer's ring marginal zone B cell lymphoma : Are the clinical and prognostic features nodal or extranodal? A study by the Consortium for Improving Survival of Lymphoma (CISL). / Oh, Sung Yong; Kim, Won Seog; Kim, Jin Seok; Kim, Seok Jin; Lee, Suee; Lee, Dae Ho; Lee, Soon Il; Kang, Hye Jin; Choi, Chul Won; Park, Jinny; Song, Moo Kon; Kim, Hyo Jung; Kwon, Jung Hye; Kwak, Jae Yong; Bae, Sung Hwa; Park, Byeong Bae; Do, Young Rok; Lee, Ho Sup; Jeong, Seong Hyun; Suh, Cheolwon; Kim, Hyo Jin.
In: International Journal of Hematology, Vol. 96, No. 5, 01.11.2012, p. 631-637.Research output: Contribution to journal › Article
TY - JOUR
T1 - Waldeyer's ring marginal zone B cell lymphoma
T2 - Are the clinical and prognostic features nodal or extranodal? A study by the Consortium for Improving Survival of Lymphoma (CISL)
AU - Oh, Sung Yong
AU - Kim, Won Seog
AU - Kim, Jin Seok
AU - Kim, Seok Jin
AU - Lee, Suee
AU - Lee, Dae Ho
AU - Lee, Soon Il
AU - Kang, Hye Jin
AU - Choi, Chul Won
AU - Park, Jinny
AU - Song, Moo Kon
AU - Kim, Hyo Jung
AU - Kwon, Jung Hye
AU - Kwak, Jae Yong
AU - Bae, Sung Hwa
AU - Park, Byeong Bae
AU - Do, Young Rok
AU - Lee, Ho Sup
AU - Jeong, Seong Hyun
AU - Suh, Cheolwon
AU - Kim, Hyo Jin
PY - 2012/11/1
Y1 - 2012/11/1
N2 - There has been controversy surrounding Waldeyer's ring (WR), especially focused on the question of whether it should be regarded as a nodal or an extranodal site. We conducted retrospective analyses of marginal zone B cell lymphomas involving WR (WR-MZLs) to observe their clinical features and prognosis, with specific regard to the nodal-or-extranodal question. A total of 52 patients with histological diagnosis of WR-MZL were retrospectively analyzed. The most common involvement site was the tonsil (40.4 %). Ann Arbor stage III/VI disease was present in 48.1 % (25 of 52). The response rate of the 27 stage I/II patients was 88.9 %, with 21 complete remissions and three partial remissions. The median time to progression (TTP) was 3.7 years (95 % CI 2.5-4.9 years). The estimated 5-year TTP and overall survival rates were 39.4 and 90.5 %, respectively. In a comparison with the historical data regarding extra-WR MALT lymphoma and nodal MZL (N-MZL), MALT lymphoma showed better TTP results than did WR-MZL and N-MZL (P\0.001).
AB - There has been controversy surrounding Waldeyer's ring (WR), especially focused on the question of whether it should be regarded as a nodal or an extranodal site. We conducted retrospective analyses of marginal zone B cell lymphomas involving WR (WR-MZLs) to observe their clinical features and prognosis, with specific regard to the nodal-or-extranodal question. A total of 52 patients with histological diagnosis of WR-MZL were retrospectively analyzed. The most common involvement site was the tonsil (40.4 %). Ann Arbor stage III/VI disease was present in 48.1 % (25 of 52). The response rate of the 27 stage I/II patients was 88.9 %, with 21 complete remissions and three partial remissions. The median time to progression (TTP) was 3.7 years (95 % CI 2.5-4.9 years). The estimated 5-year TTP and overall survival rates were 39.4 and 90.5 %, respectively. In a comparison with the historical data regarding extra-WR MALT lymphoma and nodal MZL (N-MZL), MALT lymphoma showed better TTP results than did WR-MZL and N-MZL (P\0.001).
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U2 - 10.1007/s12185-012-1200-0
DO - 10.1007/s12185-012-1200-0
M3 - Article
C2 - 23065471
AN - SCOPUS:84872180016
VL - 96
SP - 631
EP - 637
JO - International Journal of Hematology
JF - International Journal of Hematology
SN - 0925-5710
IS - 5
ER -