Waldeyer's ring marginal zone B cell lymphoma: Are the clinical and prognostic features nodal or extranodal? A study by the Consortium for Improving Survival of Lymphoma (CISL)

Sung Yong Oh, Won Seog Kim, Jin Seok Kim, Seok Jin Kim, Suee Lee, Dae Ho Lee, Soon Il Lee, Hye Jin Kang, Chul Won Choi, Jinny Park, Moo Kon Song, Hyo Jung Kim, Jung Hye Kwon, Jae Yong Kwak, Sung Hwa Bae, Byeong Bae Park, Young Rok Do, Ho Sup Lee, Seong Hyun Jeong, Cheolwon SuhHyo Jin Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

There has been controversy surrounding Waldeyer's ring (WR), especially focused on the question of whether it should be regarded as a nodal or an extranodal site. We conducted retrospective analyses of marginal zone B cell lymphomas involving WR (WR-MZLs) to observe their clinical features and prognosis, with specific regard to the nodal-or-extranodal question. A total of 52 patients with histological diagnosis of WR-MZL were retrospectively analyzed. The most common involvement site was the tonsil (40.4 %). Ann Arbor stage III/VI disease was present in 48.1 % (25 of 52). The response rate of the 27 stage I/II patients was 88.9 %, with 21 complete remissions and three partial remissions. The median time to progression (TTP) was 3.7 years (95 % CI 2.5-4.9 years). The estimated 5-year TTP and overall survival rates were 39.4 and 90.5 %, respectively. In a comparison with the historical data regarding extra-WR MALT lymphoma and nodal MZL (N-MZL), MALT lymphoma showed better TTP results than did WR-MZL and N-MZL (P\0.001).

Original languageEnglish
Pages (from-to)631-637
Number of pages7
JournalInternational Journal of Hematology
Volume96
Issue number5
DOIs
Publication statusPublished - 2012 Nov 1

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Marginal Zone B-Cell Lymphoma
Lymphoma
Survival
Palatine Tonsil
Survival Rate

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Oh, Sung Yong ; Kim, Won Seog ; Kim, Jin Seok ; Kim, Seok Jin ; Lee, Suee ; Lee, Dae Ho ; Lee, Soon Il ; Kang, Hye Jin ; Choi, Chul Won ; Park, Jinny ; Song, Moo Kon ; Kim, Hyo Jung ; Kwon, Jung Hye ; Kwak, Jae Yong ; Bae, Sung Hwa ; Park, Byeong Bae ; Do, Young Rok ; Lee, Ho Sup ; Jeong, Seong Hyun ; Suh, Cheolwon ; Kim, Hyo Jin. / Waldeyer's ring marginal zone B cell lymphoma : Are the clinical and prognostic features nodal or extranodal? A study by the Consortium for Improving Survival of Lymphoma (CISL). In: International Journal of Hematology. 2012 ; Vol. 96, No. 5. pp. 631-637.
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title = "Waldeyer's ring marginal zone B cell lymphoma: Are the clinical and prognostic features nodal or extranodal? A study by the Consortium for Improving Survival of Lymphoma (CISL)",
abstract = "There has been controversy surrounding Waldeyer's ring (WR), especially focused on the question of whether it should be regarded as a nodal or an extranodal site. We conducted retrospective analyses of marginal zone B cell lymphomas involving WR (WR-MZLs) to observe their clinical features and prognosis, with specific regard to the nodal-or-extranodal question. A total of 52 patients with histological diagnosis of WR-MZL were retrospectively analyzed. The most common involvement site was the tonsil (40.4 {\%}). Ann Arbor stage III/VI disease was present in 48.1 {\%} (25 of 52). The response rate of the 27 stage I/II patients was 88.9 {\%}, with 21 complete remissions and three partial remissions. The median time to progression (TTP) was 3.7 years (95 {\%} CI 2.5-4.9 years). The estimated 5-year TTP and overall survival rates were 39.4 and 90.5 {\%}, respectively. In a comparison with the historical data regarding extra-WR MALT lymphoma and nodal MZL (N-MZL), MALT lymphoma showed better TTP results than did WR-MZL and N-MZL (P\0.001).",
author = "Oh, {Sung Yong} and Kim, {Won Seog} and Kim, {Jin Seok} and Kim, {Seok Jin} and Suee Lee and Lee, {Dae Ho} and Lee, {Soon Il} and Kang, {Hye Jin} and Choi, {Chul Won} and Jinny Park and Song, {Moo Kon} and Kim, {Hyo Jung} and Kwon, {Jung Hye} and Kwak, {Jae Yong} and Bae, {Sung Hwa} and Park, {Byeong Bae} and Do, {Young Rok} and Lee, {Ho Sup} and Jeong, {Seong Hyun} and Cheolwon Suh and Kim, {Hyo Jin}",
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Oh, SY, Kim, WS, Kim, JS, Kim, SJ, Lee, S, Lee, DH, Lee, SI, Kang, HJ, Choi, CW, Park, J, Song, MK, Kim, HJ, Kwon, JH, Kwak, JY, Bae, SH, Park, BB, Do, YR, Lee, HS, Jeong, SH, Suh, C & Kim, HJ 2012, 'Waldeyer's ring marginal zone B cell lymphoma: Are the clinical and prognostic features nodal or extranodal? A study by the Consortium for Improving Survival of Lymphoma (CISL)', International Journal of Hematology, vol. 96, no. 5, pp. 631-637. https://doi.org/10.1007/s12185-012-1200-0

Waldeyer's ring marginal zone B cell lymphoma : Are the clinical and prognostic features nodal or extranodal? A study by the Consortium for Improving Survival of Lymphoma (CISL). / Oh, Sung Yong; Kim, Won Seog; Kim, Jin Seok; Kim, Seok Jin; Lee, Suee; Lee, Dae Ho; Lee, Soon Il; Kang, Hye Jin; Choi, Chul Won; Park, Jinny; Song, Moo Kon; Kim, Hyo Jung; Kwon, Jung Hye; Kwak, Jae Yong; Bae, Sung Hwa; Park, Byeong Bae; Do, Young Rok; Lee, Ho Sup; Jeong, Seong Hyun; Suh, Cheolwon; Kim, Hyo Jin.

In: International Journal of Hematology, Vol. 96, No. 5, 01.11.2012, p. 631-637.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Waldeyer's ring marginal zone B cell lymphoma

T2 - Are the clinical and prognostic features nodal or extranodal? A study by the Consortium for Improving Survival of Lymphoma (CISL)

AU - Oh, Sung Yong

AU - Kim, Won Seog

AU - Kim, Jin Seok

AU - Kim, Seok Jin

AU - Lee, Suee

AU - Lee, Dae Ho

AU - Lee, Soon Il

AU - Kang, Hye Jin

AU - Choi, Chul Won

AU - Park, Jinny

AU - Song, Moo Kon

AU - Kim, Hyo Jung

AU - Kwon, Jung Hye

AU - Kwak, Jae Yong

AU - Bae, Sung Hwa

AU - Park, Byeong Bae

AU - Do, Young Rok

AU - Lee, Ho Sup

AU - Jeong, Seong Hyun

AU - Suh, Cheolwon

AU - Kim, Hyo Jin

PY - 2012/11/1

Y1 - 2012/11/1

N2 - There has been controversy surrounding Waldeyer's ring (WR), especially focused on the question of whether it should be regarded as a nodal or an extranodal site. We conducted retrospective analyses of marginal zone B cell lymphomas involving WR (WR-MZLs) to observe their clinical features and prognosis, with specific regard to the nodal-or-extranodal question. A total of 52 patients with histological diagnosis of WR-MZL were retrospectively analyzed. The most common involvement site was the tonsil (40.4 %). Ann Arbor stage III/VI disease was present in 48.1 % (25 of 52). The response rate of the 27 stage I/II patients was 88.9 %, with 21 complete remissions and three partial remissions. The median time to progression (TTP) was 3.7 years (95 % CI 2.5-4.9 years). The estimated 5-year TTP and overall survival rates were 39.4 and 90.5 %, respectively. In a comparison with the historical data regarding extra-WR MALT lymphoma and nodal MZL (N-MZL), MALT lymphoma showed better TTP results than did WR-MZL and N-MZL (P\0.001).

AB - There has been controversy surrounding Waldeyer's ring (WR), especially focused on the question of whether it should be regarded as a nodal or an extranodal site. We conducted retrospective analyses of marginal zone B cell lymphomas involving WR (WR-MZLs) to observe their clinical features and prognosis, with specific regard to the nodal-or-extranodal question. A total of 52 patients with histological diagnosis of WR-MZL were retrospectively analyzed. The most common involvement site was the tonsil (40.4 %). Ann Arbor stage III/VI disease was present in 48.1 % (25 of 52). The response rate of the 27 stage I/II patients was 88.9 %, with 21 complete remissions and three partial remissions. The median time to progression (TTP) was 3.7 years (95 % CI 2.5-4.9 years). The estimated 5-year TTP and overall survival rates were 39.4 and 90.5 %, respectively. In a comparison with the historical data regarding extra-WR MALT lymphoma and nodal MZL (N-MZL), MALT lymphoma showed better TTP results than did WR-MZL and N-MZL (P\0.001).

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SN - 0925-5710

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