Warranty period of zero coronary artery calcium score for predicting all-cause mortality according to cardiac risk burden in asymptomatic Korean adults

Ji Hyun Lee, Donghee Han, Bríain ó Hartaigh, Asim Rizvi, Heidi Gransar, Hyung Bok Park, Hyo Eun Park, Su Yeon Choi, Eun Ju Chun, Jidong Sung, Sung Hak Park, Hae Won Han, James K. Min, Hyuk-Jae Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The aim of this study was to examine whether zero coronary artery calcium (CAC) score is associated with favorable prognosis of all-cause mortality (ACM) according to a panel of conventional risk factors (RF) in asymptomatic Korean adults. Methods and Results: A total of 48,215 individuals were stratified according to presence/absence of CAC, and the following RF were examined: hypertension, diabetes, current smoking, high low-density lipoprotein cholesterol, and low high-density lipoprotein cholesterol. The RF were summed on composite score as 0, 1–2, or ≥3 RF present. The warranty period was defined as the time to cumulative mortality rate >1%. Across a median follow-up of 4.4 years (IQR, 2.7–6.6), 415 (0.9%) deaths occurred. Incidence per 1,000 person-years for ACM was consistently higher in subjects with any CAC, irrespective of number of RF. The warranty period was substantially longer (eg, 9 vs. 5 years) for CAC=0 compared with CAC >0. The latter observation did not change materially according to pre-specified RF, but difference in warranty period according to presence/absence of CAC reduced somewhat when RF burden increased. Conclusions: In asymptomatic Korean adults, the absence of CAC evoked a strong protective effect against ACM as reflected by longer warranty period, when no other RF were present. The usefulness of zero CAC score and its warranty period requires further validation in the presence of multiple RF.

Original languageEnglish
Pages (from-to)2356-2361
Number of pages6
JournalCirculation Journal
Volume80
Issue number11
DOIs
Publication statusPublished - 2016 Jan 1

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Coronary Vessels
Calcium
Mortality
LDL Cholesterol
HDL Cholesterol
Smoking
Observation
Hypertension
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Lee, Ji Hyun ; Han, Donghee ; ó Hartaigh, Bríain ; Rizvi, Asim ; Gransar, Heidi ; Park, Hyung Bok ; Park, Hyo Eun ; Choi, Su Yeon ; Chun, Eun Ju ; Sung, Jidong ; Park, Sung Hak ; Han, Hae Won ; Min, James K. ; Chang, Hyuk-Jae. / Warranty period of zero coronary artery calcium score for predicting all-cause mortality according to cardiac risk burden in asymptomatic Korean adults. In: Circulation Journal. 2016 ; Vol. 80, No. 11. pp. 2356-2361.
@article{c34c7f0f65a34993bcb014a9ec06d5c5,
title = "Warranty period of zero coronary artery calcium score for predicting all-cause mortality according to cardiac risk burden in asymptomatic Korean adults",
abstract = "Background: The aim of this study was to examine whether zero coronary artery calcium (CAC) score is associated with favorable prognosis of all-cause mortality (ACM) according to a panel of conventional risk factors (RF) in asymptomatic Korean adults. Methods and Results: A total of 48,215 individuals were stratified according to presence/absence of CAC, and the following RF were examined: hypertension, diabetes, current smoking, high low-density lipoprotein cholesterol, and low high-density lipoprotein cholesterol. The RF were summed on composite score as 0, 1–2, or ≥3 RF present. The warranty period was defined as the time to cumulative mortality rate >1{\%}. Across a median follow-up of 4.4 years (IQR, 2.7–6.6), 415 (0.9{\%}) deaths occurred. Incidence per 1,000 person-years for ACM was consistently higher in subjects with any CAC, irrespective of number of RF. The warranty period was substantially longer (eg, 9 vs. 5 years) for CAC=0 compared with CAC >0. The latter observation did not change materially according to pre-specified RF, but difference in warranty period according to presence/absence of CAC reduced somewhat when RF burden increased. Conclusions: In asymptomatic Korean adults, the absence of CAC evoked a strong protective effect against ACM as reflected by longer warranty period, when no other RF were present. The usefulness of zero CAC score and its warranty period requires further validation in the presence of multiple RF.",
author = "Lee, {Ji Hyun} and Donghee Han and {{\'o} Hartaigh}, Br{\'i}ain and Asim Rizvi and Heidi Gransar and Park, {Hyung Bok} and Park, {Hyo Eun} and Choi, {Su Yeon} and Chun, {Eun Ju} and Jidong Sung and Park, {Sung Hak} and Han, {Hae Won} and Min, {James K.} and Hyuk-Jae Chang",
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Lee, JH, Han, D, ó Hartaigh, B, Rizvi, A, Gransar, H, Park, HB, Park, HE, Choi, SY, Chun, EJ, Sung, J, Park, SH, Han, HW, Min, JK & Chang, H-J 2016, 'Warranty period of zero coronary artery calcium score for predicting all-cause mortality according to cardiac risk burden in asymptomatic Korean adults', Circulation Journal, vol. 80, no. 11, pp. 2356-2361. https://doi.org/10.1253/circj.CJ-16-0731

Warranty period of zero coronary artery calcium score for predicting all-cause mortality according to cardiac risk burden in asymptomatic Korean adults. / Lee, Ji Hyun; Han, Donghee; ó Hartaigh, Bríain; Rizvi, Asim; Gransar, Heidi; Park, Hyung Bok; Park, Hyo Eun; Choi, Su Yeon; Chun, Eun Ju; Sung, Jidong; Park, Sung Hak; Han, Hae Won; Min, James K.; Chang, Hyuk-Jae.

In: Circulation Journal, Vol. 80, No. 11, 01.01.2016, p. 2356-2361.

Research output: Contribution to journalArticle

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T1 - Warranty period of zero coronary artery calcium score for predicting all-cause mortality according to cardiac risk burden in asymptomatic Korean adults

AU - Lee, Ji Hyun

AU - Han, Donghee

AU - ó Hartaigh, Bríain

AU - Rizvi, Asim

AU - Gransar, Heidi

AU - Park, Hyung Bok

AU - Park, Hyo Eun

AU - Choi, Su Yeon

AU - Chun, Eun Ju

AU - Sung, Jidong

AU - Park, Sung Hak

AU - Han, Hae Won

AU - Min, James K.

AU - Chang, Hyuk-Jae

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: The aim of this study was to examine whether zero coronary artery calcium (CAC) score is associated with favorable prognosis of all-cause mortality (ACM) according to a panel of conventional risk factors (RF) in asymptomatic Korean adults. Methods and Results: A total of 48,215 individuals were stratified according to presence/absence of CAC, and the following RF were examined: hypertension, diabetes, current smoking, high low-density lipoprotein cholesterol, and low high-density lipoprotein cholesterol. The RF were summed on composite score as 0, 1–2, or ≥3 RF present. The warranty period was defined as the time to cumulative mortality rate >1%. Across a median follow-up of 4.4 years (IQR, 2.7–6.6), 415 (0.9%) deaths occurred. Incidence per 1,000 person-years for ACM was consistently higher in subjects with any CAC, irrespective of number of RF. The warranty period was substantially longer (eg, 9 vs. 5 years) for CAC=0 compared with CAC >0. The latter observation did not change materially according to pre-specified RF, but difference in warranty period according to presence/absence of CAC reduced somewhat when RF burden increased. Conclusions: In asymptomatic Korean adults, the absence of CAC evoked a strong protective effect against ACM as reflected by longer warranty period, when no other RF were present. The usefulness of zero CAC score and its warranty period requires further validation in the presence of multiple RF.

AB - Background: The aim of this study was to examine whether zero coronary artery calcium (CAC) score is associated with favorable prognosis of all-cause mortality (ACM) according to a panel of conventional risk factors (RF) in asymptomatic Korean adults. Methods and Results: A total of 48,215 individuals were stratified according to presence/absence of CAC, and the following RF were examined: hypertension, diabetes, current smoking, high low-density lipoprotein cholesterol, and low high-density lipoprotein cholesterol. The RF were summed on composite score as 0, 1–2, or ≥3 RF present. The warranty period was defined as the time to cumulative mortality rate >1%. Across a median follow-up of 4.4 years (IQR, 2.7–6.6), 415 (0.9%) deaths occurred. Incidence per 1,000 person-years for ACM was consistently higher in subjects with any CAC, irrespective of number of RF. The warranty period was substantially longer (eg, 9 vs. 5 years) for CAC=0 compared with CAC >0. The latter observation did not change materially according to pre-specified RF, but difference in warranty period according to presence/absence of CAC reduced somewhat when RF burden increased. Conclusions: In asymptomatic Korean adults, the absence of CAC evoked a strong protective effect against ACM as reflected by longer warranty period, when no other RF were present. The usefulness of zero CAC score and its warranty period requires further validation in the presence of multiple RF.

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