Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

Ivan Gusachenko, Mingzhou Chen, Kishan Dholakia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Raman spectroscopy is a valuable tool for non-invasive and label-free identification of sample chemical composition. Recently a few miniaturized optical probes emerged driven by the need to address areas of difficult access, such as in endoscopy. However, imaging modality is still out of reach for most of them. Separately, recent advances in wavefront shaping enabled different microscopies to be applied in various complex media including multimode fibers. Here we present the first and thinnest to date Raman fiber imaging probe based on wavefront shaping through a single multimode fiber without use of any additional optics. We image agglomerates of bacteria and pharmaceuticals to demonstrate the capability of our method. This work paves the way towards compact and flexible Raman endoscopy.

Original languageEnglish
Title of host publicationBiomedical Imaging and Sensing Conference
EditorsYasuhiro Awatsuji, Osamu Matoba, Yoshihisa Aizu, Toyohiko Yatagai
PublisherSPIE
ISBN (Electronic)9781510610033
DOIs
Publication statusPublished - 2017 Jan 1
Event3rd Biomedical Imaging and Sensing Conference - Yokohama, Japan
Duration: 2017 Apr 192017 Apr 21

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume10251
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

Conference3rd Biomedical Imaging and Sensing Conference
CountryJapan
CityYokohama
Period17/4/1917/4/21

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All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Gusachenko, I., Chen, M., & Dholakia, K. (2017). Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes. In Y. Awatsuji, O. Matoba, Y. Aizu, & T. Yatagai (Eds.), Biomedical Imaging and Sensing Conference [1025104] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10251). SPIE. https://doi.org/10.1117/12.2274974