Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics

Joohee Kim, Minji Kim, Mi Sun Lee, Kukjoo Kim, Sangyoon Ji, Yun Tae Kim, Jihun Park, Kyungmin Na, Kwi Hyun Bae, Hong Kyun Kim, Franklin Bien, Chang Young Lee, Jang Ung Park

Research output: Contribution to journalArticle

230 Citations (Scopus)

Abstract

Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses.

Original languageEnglish
Article number14997
JournalNature communications
Volume8
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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    Kim, J., Kim, M., Lee, M. S., Kim, K., Ji, S., Kim, Y. T., Park, J., Na, K., Bae, K. H., Kim, H. K., Bien, F., Lee, C. Y., & Park, J. U. (2017). Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics. Nature communications, 8, [14997]. https://doi.org/10.1038/ncomms14997