Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics

Joohee Kim, Minji Kim, Mi Sun Lee, Kukjoo Kim, Sangyoon Ji, Yun Tae Kim, Jihun Park, Kyungmin Na, Kwi Hyun Bae, Hong Kyun Kim, Franklin Bien, Chang Young Lee, Jang Ung Park

Research output: Contribution to journalArticlepeer-review

302 Citations (Scopus)

Abstract

Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses.

Original languageEnglish
Article number14997
JournalNature communications
Volume8
DOIs
Publication statusPublished - 2017

Bibliographical note

Funding Information:
This work was supported by the Ministry of Science, ICT & Future Planning and the Ministry of Trade, Industry and Energy (MOTIE) of Korea through the National Research Foundation (2016R1A2B3013592 and 2016R1A5A1009926), the Technology Innovation Program (Grant 10044410), the Nano Material Technology Development Program (2015M3A7B4050308 and 2016M3A7B4910635), the Convergence Technology Development Program for Bionic Arm (NRF-2014M3C1B2048198), the Pioneer Research Center Program (NRF-2014M3C1A3001208), the Human Resource Training Program for Regional Innovation and Creativity (NRF-2014H1C1A1073051). Also, the authors thank CooperVision Awards and financial support by the Development Program of Manufacturing Technology for Flexible Electronics with High Performance (SC0970) funded by the Korea Institute of Machinery and Materials, and by the Development Program of Internet of Nature System (1.150090.01) funded by UNIST.

Publisher Copyright:
© The Author(s) 2017.

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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