Wearable Surface-Lighting Micro-Light-Emitting Diode Patch for Melanogenesis Inhibition

Jae Hee Lee; Yuri Ahn; Han Eol Lee; You Na Jang; A. Yeon Park; Shinho Kim; Young Hoon Jung; Sang Hyun Sung; Jung Ho Shin; Seung Hyung Lee; Sang Hyun Park; Ki Soo Kim; Min Seok Jang; Beom Joon Kim; Sang Ho Oh; Keon Jae Lee

doi:10.1002/adhm.202201796

Wearable Surface-Lighting Micro-Light-Emitting Diode Patch for Melanogenesis Inhibition

Jae Hee Lee, Yuri Ahn, Han Eol Lee, You Na Jang, A. Yeon Park, Shinho Kim, Young Hoon Jung, Sang Hyun Sung, Jung Ho Shin, Seung Hyung Lee, Sang Hyun Park, Ki Soo Kim, Min Seok Jang, Beom Joon Kim, Sang Ho Oh, Keon Jae Lee

Department of Dermatology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Wearable light-emitting diode (LED)-based phototherapeutic devices have recently attracted attention as skin care tools for wrinkles, acne, and hyperpigmentation. However, the therapeutic effectiveness and safety of LED stimulators are still controversial due to their inefficient light transfer, high heat generation, and non-uniform spot irradiation. Here, a wearable surface-lighting micro-LED (SµLED) photostimulator is reported for skin care and cosmetic applications. The SµLEDs, consisting of a light diffusion layer (LDL), 900 thin film µLEDs, and polydimethylsiloxane (PDMS), achieve uniform surface-lighting in 2 × 2 cm²-sized area with 100% emission yields. The SµLEDs maximize photostimulation effectiveness on the skin surface by uniform irradiation, high flexibility, and thermal stability. The SµLED's effect on melanogenesis inhibition is evaluated via in vitro and in vivo experiments to human skin equivalents (HSEs) and mouse dorsal skin, respectively. The anti-melanogenic effect of SµLEDs is confirmed by significantly reduced levels of melanin contents, melan-A, tyrosinase, and microphthalmia-associated transcription factor (MITF), compared to a conventional LED (CLED) stimulator.

Original language	English
Article number	2201796
Journal	Advanced Healthcare Materials
Volume	12
Issue number	1
DOIs	https://doi.org/10.1002/adhm.202201796
Publication status	Published - 2023 Jan 2

Bibliographical note

Funding Information:
J.H.L and Y.A contributed equally to this work. This work was supported by the Wearable Platform Materials Technology Center (WMC) funded by the National Research Foundation of Korea (NRF) Grant by the Korean Government (MSIT) (NRF‐2022R1A5A6000846), the Convergent Technology R&D Program for Human Augmentation (NRF‐2020M3C1B8081519) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT, and the Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2016M3D1A1900035 and 2016M3D1A1900038). The authors would like to thank Fronics Co., Ltd for support.

Publisher Copyright:
© 2022 Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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10.1002/adhm.202201796

Cite this

Lee, J. H., Ahn, Y., Lee, H. E., Jang, Y. N., Park, A. Y., Kim, S., Jung, Y. H., Sung, S. H., Shin, J. H., Lee, S. H., Park, S. H., Kim, K. S., Jang, M. S., Kim, B. J., Oh, S. H., & Lee, K. J. (2023). Wearable Surface-Lighting Micro-Light-Emitting Diode Patch for Melanogenesis Inhibition. Advanced Healthcare Materials, 12(1), [2201796]. https://doi.org/10.1002/adhm.202201796

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title = "Wearable Surface-Lighting Micro-Light-Emitting Diode Patch for Melanogenesis Inhibition",

abstract = "Wearable light-emitting diode (LED)-based phototherapeutic devices have recently attracted attention as skin care tools for wrinkles, acne, and hyperpigmentation. However, the therapeutic effectiveness and safety of LED stimulators are still controversial due to their inefficient light transfer, high heat generation, and non-uniform spot irradiation. Here, a wearable surface-lighting micro-LED (SµLED) photostimulator is reported for skin care and cosmetic applications. The SµLEDs, consisting of a light diffusion layer (LDL), 900 thin film µLEDs, and polydimethylsiloxane (PDMS), achieve uniform surface-lighting in 2 × 2 cm2-sized area with 100% emission yields. The SµLEDs maximize photostimulation effectiveness on the skin surface by uniform irradiation, high flexibility, and thermal stability. The SµLED's effect on melanogenesis inhibition is evaluated via in vitro and in vivo experiments to human skin equivalents (HSEs) and mouse dorsal skin, respectively. The anti-melanogenic effect of SµLEDs is confirmed by significantly reduced levels of melanin contents, melan-A, tyrosinase, and microphthalmia-associated transcription factor (MITF), compared to a conventional LED (CLED) stimulator.",

author = "Lee, {Jae Hee} and Yuri Ahn and Lee, {Han Eol} and Jang, {You Na} and Park, {A. Yeon} and Shinho Kim and Jung, {Young Hoon} and Sung, {Sang Hyun} and Shin, {Jung Ho} and Lee, {Seung Hyung} and Park, {Sang Hyun} and Kim, {Ki Soo} and Jang, {Min Seok} and Kim, {Beom Joon} and Oh, {Sang Ho} and Lee, {Keon Jae}",

note = "Funding Information: J.H.L and Y.A contributed equally to this work. This work was supported by the Wearable Platform Materials Technology Center (WMC) funded by the National Research Foundation of Korea (NRF) Grant by the Korean Government (MSIT) (NRF‐2022R1A5A6000846), the Convergent Technology R&D Program for Human Augmentation (NRF‐2020M3C1B8081519) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT, and the Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2016M3D1A1900035 and 2016M3D1A1900038). The authors would like to thank Fronics Co., Ltd for support. Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",

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doi = "10.1002/adhm.202201796",

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AU - Lee, Jae Hee

AU - Ahn, Yuri

AU - Lee, Han Eol

AU - Jang, You Na

AU - Park, A. Yeon

AU - Kim, Shinho

AU - Jung, Young Hoon

AU - Sung, Sang Hyun

AU - Shin, Jung Ho

AU - Lee, Seung Hyung

AU - Park, Sang Hyun

AU - Kim, Ki Soo

AU - Jang, Min Seok

AU - Kim, Beom Joon

AU - Oh, Sang Ho

AU - Lee, Keon Jae

N1 - Funding Information: J.H.L and Y.A contributed equally to this work. This work was supported by the Wearable Platform Materials Technology Center (WMC) funded by the National Research Foundation of Korea (NRF) Grant by the Korean Government (MSIT) (NRF‐2022R1A5A6000846), the Convergent Technology R&D Program for Human Augmentation (NRF‐2020M3C1B8081519) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT, and the Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2016M3D1A1900035 and 2016M3D1A1900038). The authors would like to thank Fronics Co., Ltd for support. Publisher Copyright: © 2022 Wiley-VCH GmbH.

PY - 2023/1/2

Y1 - 2023/1/2

N2 - Wearable light-emitting diode (LED)-based phototherapeutic devices have recently attracted attention as skin care tools for wrinkles, acne, and hyperpigmentation. However, the therapeutic effectiveness and safety of LED stimulators are still controversial due to their inefficient light transfer, high heat generation, and non-uniform spot irradiation. Here, a wearable surface-lighting micro-LED (SµLED) photostimulator is reported for skin care and cosmetic applications. The SµLEDs, consisting of a light diffusion layer (LDL), 900 thin film µLEDs, and polydimethylsiloxane (PDMS), achieve uniform surface-lighting in 2 × 2 cm2-sized area with 100% emission yields. The SµLEDs maximize photostimulation effectiveness on the skin surface by uniform irradiation, high flexibility, and thermal stability. The SµLED's effect on melanogenesis inhibition is evaluated via in vitro and in vivo experiments to human skin equivalents (HSEs) and mouse dorsal skin, respectively. The anti-melanogenic effect of SµLEDs is confirmed by significantly reduced levels of melanin contents, melan-A, tyrosinase, and microphthalmia-associated transcription factor (MITF), compared to a conventional LED (CLED) stimulator.

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Wearable Surface-Lighting Micro-Light-Emitting Diode Patch for Melanogenesis Inhibition

Abstract

Bibliographical note

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