Weekly full-dose gemcitabine and single-dose cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer

S. P. Hong, J. Y. Park, T. J. Jeon, S. Bang, S. W. Park, J. B. Chung, M. S. Park, J. Seong, W. J. Lee, S. Y. Song

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The aim of this study was to evaluate the efficacy and the toxicity of a full dose of gemcitabine and a single dose of cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer. Forty-one patients with locally advanced pancreatic cancer were enrolled. Patients received gemcitabine (1000 mg m-2 on days 1, 8, 15, 29, and 36) and cisplatin (70 mg m-2 on days 1 and 29) with concurrent radiotherapy (45 Gy in 25 fractions). Treatment was completed in 38 out of 41 patients (92.7%). The overall response rate was 24.4% (two complete and eight partial). Six patients (14.6%) underwent definite pancreatic resection and four had negative surgical margins. The intention of the treatment analysis showed that the median survival time and median time to tumour progression were 16.7 and 8.9 months. The 1- and 2-year survival rates were 63.3 and 27.9%, respectively. Overall survival was significantly longer in the low baseline CA19-9 group and therapeutic responders. Toxicities were tolerable and successfully managed by conservative treatments. The therapeutic scheme of a weekly full dose of gemcitabine and a single dose of cisplatin combined with external radiation is effective and might prolong the survival of patients with locally advanced pancreatic cancer.

Original languageEnglish
Pages (from-to)881-887
Number of pages7
JournalBritish journal of cancer
Volume98
Issue number5
DOIs
Publication statusPublished - 2008 Mar 11

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Weekly full-dose gemcitabine and single-dose cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer'. Together they form a unique fingerprint.

  • Cite this

    Hong, S. P., Park, J. Y., Jeon, T. J., Bang, S., Park, S. W., Chung, J. B., Park, M. S., Seong, J., Lee, W. J., & Song, S. Y. (2008). Weekly full-dose gemcitabine and single-dose cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer. British journal of cancer, 98(5), 881-887. https://doi.org/10.1038/sj.bjc.6604247