Weight change is a characteristic non- motor symptom in drug-naïve Parkinson's disease patients with non-Tremor dominant subtype: A nation-wide observational study

Jun Kyu Mun, Jinyoung Youn, Jin Whan Cho, Eung Seok Oh, Ji Sun Kim, Suyeon Park, Wooyoung Jang, Jin Se Park, Seong Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han Joon Kim, Beom S. Jeon, Hae Won Shin, Sun Ah Choi, Sang Jin Kim, Seong Min Choi, Ji Yun Park, Ji Young Kim, Sun Ju ChungChong Sik Lee, Tae Beom Ahn, Won Chan Kim, Hyun Sook Kim, Sang Myung Cheon, Jae Woo Kim, Hee Tae Kim, Jee Young Lee, Eun Joo Kim, Jong Min Kim, Kwang Soo Lee, Joong Seok Kim, Min Jeong Kim, Jong Sam Baik, Ki Jong Park, Hee Jin Kim, Mee Young Park, Ji Hoon Kang, Sook Kun Song, Yong Duk Kim, Ji Young Yun, Ho Won Lee, In Uk Song, Young H. Sohn, philhyu Lee, Jeong Ho Park, Hyung Geun Oh, Kun Woo Park, Do Young Kwon

Research output: Contribution to journalArticle

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Abstract

Despite the clinical impact of non-motor symptoms (NMS) in Parkinson's disease (PD), the characteristicNMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes.We enrolled 136 drug-naïve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor dominant (TD) and non-Tremor dominant (NTD) subtypes. The Non-Motor Symptom Scale and scales for each NMS were completed.We compared NMS and the relationship of NMS with quality of life between normal controls and PD patients, and between the PD subtypes. Comparing with normal controls, PD patients complained of more NMS, especially mood/cognitive symptoms, gastrointestinal symptoms, unexplained pain, weight change, and change in taste or smell. Between the PD subtypes, the NTD subtype showed higher total NMS scale score and sub-score about weight change. Weight change was the characteristicNMS related to NTD subtype even after controlled other variables with logistic regression analysis. Even from the early stage, PD patients suffer from various NMS regardless of dopaminergic medication. Among the various NMS, weight change is the characteristicNMS associated with NTD subtype in PD patients.

Original languageEnglish
Article numbere0162254
JournalPloS one
Volume11
Issue number9
DOIs
Publication statusPublished - 2016 Sep 1

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Parkinson disease
observational studies
signs and symptoms (animals and humans)
Observational Studies
Parkinson Disease
Weights and Measures
drugs
Pharmaceutical Preparations
Disease control
Neurobehavioral Manifestations
Smell
Tremor
Regression analysis
emotions
smell
quality of life
Logistics
drug therapy
pain
regression analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Mun, Jun Kyu ; Youn, Jinyoung ; Cho, Jin Whan ; Oh, Eung Seok ; Kim, Ji Sun ; Park, Suyeon ; Jang, Wooyoung ; Park, Jin Se ; Koh, Seong Beom ; Lee, Jae Hyeok ; Park, Hee Kyung ; Kim, Han Joon ; Jeon, Beom S. ; Shin, Hae Won ; Choi, Sun Ah ; Kim, Sang Jin ; Choi, Seong Min ; Park, Ji Yun ; Kim, Ji Young ; Chung, Sun Ju ; Lee, Chong Sik ; Ahn, Tae Beom ; Kim, Won Chan ; Kim, Hyun Sook ; Cheon, Sang Myung ; Kim, Jae Woo ; Kim, Hee Tae ; Lee, Jee Young ; Kim, Eun Joo ; Kim, Jong Min ; Lee, Kwang Soo ; Kim, Joong Seok ; Kim, Min Jeong ; Baik, Jong Sam ; Park, Ki Jong ; Kim, Hee Jin ; Park, Mee Young ; Kang, Ji Hoon ; Song, Sook Kun ; Kim, Yong Duk ; Yun, Ji Young ; Lee, Ho Won ; Song, In Uk ; Sohn, Young H. ; Lee, philhyu ; Park, Jeong Ho ; Oh, Hyung Geun ; Park, Kun Woo ; Kwon, Do Young. / Weight change is a characteristic non- motor symptom in drug-naïve Parkinson's disease patients with non-Tremor dominant subtype : A nation-wide observational study. In: PloS one. 2016 ; Vol. 11, No. 9.
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title = "Weight change is a characteristic non- motor symptom in drug-na{\"i}ve Parkinson's disease patients with non-Tremor dominant subtype: A nation-wide observational study",
abstract = "Despite the clinical impact of non-motor symptoms (NMS) in Parkinson's disease (PD), the characteristicNMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-na{\"i}ve PD patients and compared NMS between PD subtypes.We enrolled 136 drug-na{\"i}ve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor dominant (TD) and non-Tremor dominant (NTD) subtypes. The Non-Motor Symptom Scale and scales for each NMS were completed.We compared NMS and the relationship of NMS with quality of life between normal controls and PD patients, and between the PD subtypes. Comparing with normal controls, PD patients complained of more NMS, especially mood/cognitive symptoms, gastrointestinal symptoms, unexplained pain, weight change, and change in taste or smell. Between the PD subtypes, the NTD subtype showed higher total NMS scale score and sub-score about weight change. Weight change was the characteristicNMS related to NTD subtype even after controlled other variables with logistic regression analysis. Even from the early stage, PD patients suffer from various NMS regardless of dopaminergic medication. Among the various NMS, weight change is the characteristicNMS associated with NTD subtype in PD patients.",
author = "Mun, {Jun Kyu} and Jinyoung Youn and Cho, {Jin Whan} and Oh, {Eung Seok} and Kim, {Ji Sun} and Suyeon Park and Wooyoung Jang and Park, {Jin Se} and Koh, {Seong Beom} and Lee, {Jae Hyeok} and Park, {Hee Kyung} and Kim, {Han Joon} and Jeon, {Beom S.} and Shin, {Hae Won} and Choi, {Sun Ah} and Kim, {Sang Jin} and Choi, {Seong Min} and Park, {Ji Yun} and Kim, {Ji Young} and Chung, {Sun Ju} and Lee, {Chong Sik} and Ahn, {Tae Beom} and Kim, {Won Chan} and Kim, {Hyun Sook} and Cheon, {Sang Myung} and Kim, {Jae Woo} and Kim, {Hee Tae} and Lee, {Jee Young} and Kim, {Eun Joo} and Kim, {Jong Min} and Lee, {Kwang Soo} and Kim, {Joong Seok} and Kim, {Min Jeong} and Baik, {Jong Sam} and Park, {Ki Jong} and Kim, {Hee Jin} and Park, {Mee Young} and Kang, {Ji Hoon} and Song, {Sook Kun} and Kim, {Yong Duk} and Yun, {Ji Young} and Lee, {Ho Won} and Song, {In Uk} and Sohn, {Young H.} and philhyu Lee and Park, {Jeong Ho} and Oh, {Hyung Geun} and Park, {Kun Woo} and Kwon, {Do Young}",
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language = "English",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
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Mun, JK, Youn, J, Cho, JW, Oh, ES, Kim, JS, Park, S, Jang, W, Park, JS, Koh, SB, Lee, JH, Park, HK, Kim, HJ, Jeon, BS, Shin, HW, Choi, SA, Kim, SJ, Choi, SM, Park, JY, Kim, JY, Chung, SJ, Lee, CS, Ahn, TB, Kim, WC, Kim, HS, Cheon, SM, Kim, JW, Kim, HT, Lee, JY, Kim, EJ, Kim, JM, Lee, KS, Kim, JS, Kim, MJ, Baik, JS, Park, KJ, Kim, HJ, Park, MY, Kang, JH, Song, SK, Kim, YD, Yun, JY, Lee, HW, Song, IU, Sohn, YH, Lee, P, Park, JH, Oh, HG, Park, KW & Kwon, DY 2016, 'Weight change is a characteristic non- motor symptom in drug-naïve Parkinson's disease patients with non-Tremor dominant subtype: A nation-wide observational study', PloS one, vol. 11, no. 9, e0162254. https://doi.org/10.1371/journal.pone.0162254

Weight change is a characteristic non- motor symptom in drug-naïve Parkinson's disease patients with non-Tremor dominant subtype : A nation-wide observational study. / Mun, Jun Kyu; Youn, Jinyoung; Cho, Jin Whan; Oh, Eung Seok; Kim, Ji Sun; Park, Suyeon; Jang, Wooyoung; Park, Jin Se; Koh, Seong Beom; Lee, Jae Hyeok; Park, Hee Kyung; Kim, Han Joon; Jeon, Beom S.; Shin, Hae Won; Choi, Sun Ah; Kim, Sang Jin; Choi, Seong Min; Park, Ji Yun; Kim, Ji Young; Chung, Sun Ju; Lee, Chong Sik; Ahn, Tae Beom; Kim, Won Chan; Kim, Hyun Sook; Cheon, Sang Myung; Kim, Jae Woo; Kim, Hee Tae; Lee, Jee Young; Kim, Eun Joo; Kim, Jong Min; Lee, Kwang Soo; Kim, Joong Seok; Kim, Min Jeong; Baik, Jong Sam; Park, Ki Jong; Kim, Hee Jin; Park, Mee Young; Kang, Ji Hoon; Song, Sook Kun; Kim, Yong Duk; Yun, Ji Young; Lee, Ho Won; Song, In Uk; Sohn, Young H.; Lee, philhyu; Park, Jeong Ho; Oh, Hyung Geun; Park, Kun Woo; Kwon, Do Young.

In: PloS one, Vol. 11, No. 9, e0162254, 01.09.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Weight change is a characteristic non- motor symptom in drug-naïve Parkinson's disease patients with non-Tremor dominant subtype

T2 - A nation-wide observational study

AU - Mun, Jun Kyu

AU - Youn, Jinyoung

AU - Cho, Jin Whan

AU - Oh, Eung Seok

AU - Kim, Ji Sun

AU - Park, Suyeon

AU - Jang, Wooyoung

AU - Park, Jin Se

AU - Koh, Seong Beom

AU - Lee, Jae Hyeok

AU - Park, Hee Kyung

AU - Kim, Han Joon

AU - Jeon, Beom S.

AU - Shin, Hae Won

AU - Choi, Sun Ah

AU - Kim, Sang Jin

AU - Choi, Seong Min

AU - Park, Ji Yun

AU - Kim, Ji Young

AU - Chung, Sun Ju

AU - Lee, Chong Sik

AU - Ahn, Tae Beom

AU - Kim, Won Chan

AU - Kim, Hyun Sook

AU - Cheon, Sang Myung

AU - Kim, Jae Woo

AU - Kim, Hee Tae

AU - Lee, Jee Young

AU - Kim, Eun Joo

AU - Kim, Jong Min

AU - Lee, Kwang Soo

AU - Kim, Joong Seok

AU - Kim, Min Jeong

AU - Baik, Jong Sam

AU - Park, Ki Jong

AU - Kim, Hee Jin

AU - Park, Mee Young

AU - Kang, Ji Hoon

AU - Song, Sook Kun

AU - Kim, Yong Duk

AU - Yun, Ji Young

AU - Lee, Ho Won

AU - Song, In Uk

AU - Sohn, Young H.

AU - Lee, philhyu

AU - Park, Jeong Ho

AU - Oh, Hyung Geun

AU - Park, Kun Woo

AU - Kwon, Do Young

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Despite the clinical impact of non-motor symptoms (NMS) in Parkinson's disease (PD), the characteristicNMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes.We enrolled 136 drug-naïve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor dominant (TD) and non-Tremor dominant (NTD) subtypes. The Non-Motor Symptom Scale and scales for each NMS were completed.We compared NMS and the relationship of NMS with quality of life between normal controls and PD patients, and between the PD subtypes. Comparing with normal controls, PD patients complained of more NMS, especially mood/cognitive symptoms, gastrointestinal symptoms, unexplained pain, weight change, and change in taste or smell. Between the PD subtypes, the NTD subtype showed higher total NMS scale score and sub-score about weight change. Weight change was the characteristicNMS related to NTD subtype even after controlled other variables with logistic regression analysis. Even from the early stage, PD patients suffer from various NMS regardless of dopaminergic medication. Among the various NMS, weight change is the characteristicNMS associated with NTD subtype in PD patients.

AB - Despite the clinical impact of non-motor symptoms (NMS) in Parkinson's disease (PD), the characteristicNMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes.We enrolled 136 drug-naïve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor dominant (TD) and non-Tremor dominant (NTD) subtypes. The Non-Motor Symptom Scale and scales for each NMS were completed.We compared NMS and the relationship of NMS with quality of life between normal controls and PD patients, and between the PD subtypes. Comparing with normal controls, PD patients complained of more NMS, especially mood/cognitive symptoms, gastrointestinal symptoms, unexplained pain, weight change, and change in taste or smell. Between the PD subtypes, the NTD subtype showed higher total NMS scale score and sub-score about weight change. Weight change was the characteristicNMS related to NTD subtype even after controlled other variables with logistic regression analysis. Even from the early stage, PD patients suffer from various NMS regardless of dopaminergic medication. Among the various NMS, weight change is the characteristicNMS associated with NTD subtype in PD patients.

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DO - 10.1371/journal.pone.0162254

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