Weight change is a characteristic non- motor symptom in drug-naïve Parkinson's disease patients with non-Tremor dominant subtype: A nation-wide observational study

Jun Kyu Mun, Jinyoung Youn, Jin Whan Cho, Eung Seok Oh, Ji Sun Kim, Suyeon Park, Wooyoung Jang, Jin Se Park, Seong Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han Joon Kim, Beom S. Jeon, Hae Won Shin, Sun Ah Choi, Sang Jin Kim, Seong Min Choi, Ji Yun Park, Ji Young Kim, Sun Ju ChungChong Sik Lee, Tae Beom Ahn, Won Chan Kim, Hyun Sook Kim, Sang Myung Cheon, Jae Woo Kim, Hee Tae Kim, Jee Young Lee, Eun Joo Kim, Jong Min Kim, Kwang Soo Lee, Joong Seok Kim, Min Jeong Kim, Jong Sam Baik, Ki Jong Park, Hee Jin Kim, Mee Young Park, Ji Hoon Kang, Sook Kun Song, Yong Duk Kim, Ji Young Yun, Ho Won Lee, In Uk Song, Young H. Sohn, Phil Hyu Lee, Jeong Ho Park, Hyung Geun Oh, Kun Woo Park, Do Young Kwon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Despite the clinical impact of non-motor symptoms (NMS) in Parkinson's disease (PD), the characteristicNMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes.We enrolled 136 drug-naïve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor dominant (TD) and non-Tremor dominant (NTD) subtypes. The Non-Motor Symptom Scale and scales for each NMS were completed.We compared NMS and the relationship of NMS with quality of life between normal controls and PD patients, and between the PD subtypes. Comparing with normal controls, PD patients complained of more NMS, especially mood/cognitive symptoms, gastrointestinal symptoms, unexplained pain, weight change, and change in taste or smell. Between the PD subtypes, the NTD subtype showed higher total NMS scale score and sub-score about weight change. Weight change was the characteristicNMS related to NTD subtype even after controlled other variables with logistic regression analysis. Even from the early stage, PD patients suffer from various NMS regardless of dopaminergic medication. Among the various NMS, weight change is the characteristicNMS associated with NTD subtype in PD patients.

Original languageEnglish
Article numbere0162254
JournalPloS one
Volume11
Issue number9
DOIs
Publication statusPublished - 2016 Sep

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'Weight change is a characteristic non- motor symptom in drug-naïve Parkinson's disease patients with non-Tremor dominant subtype: A nation-wide observational study'. Together they form a unique fingerprint.

  • Cite this

    Mun, J. K., Youn, J., Cho, J. W., Oh, E. S., Kim, J. S., Park, S., Jang, W., Park, J. S., Koh, S. B., Lee, J. H., Park, H. K., Kim, H. J., Jeon, B. S., Shin, H. W., Choi, S. A., Kim, S. J., Choi, S. M., Park, J. Y., Kim, J. Y., ... Kwon, D. Y. (2016). Weight change is a characteristic non- motor symptom in drug-naïve Parkinson's disease patients with non-Tremor dominant subtype: A nation-wide observational study. PloS one, 11(9), [e0162254]. https://doi.org/10.1371/journal.pone.0162254