Abstract
Wernicke’s encephalopathy is an acute neurological disorder characterized by mental confusion, oculomotor dysfunction, and ataxia. It has been reported in individuals with alcohol dependence, hyperemesis gravidarum, and prolonged parenteral nutrition without vitamin supplementation. Here we present the case of a 13-year-old male patient with neuroblastoma and a history of poor oral intake and nausea for 3 months. After admission, he showed gait disturbances, nystagmus, and excessive dizziness; his mental state, however, indicated he was alert, which did not fit the classical triad of Wernicke’s encephalopathy. A diagnosis of Wernicke’s encephalopathy was made only after brain magnetic resonance imaging and serum thiamine level analyses were performed. The patient’s symptoms remained after 5 days of treatment with 100-mg thiamine once daily; thus, we increased the dosage to 500 mg 3 times daily, 1,500 mg per day. His symptoms then improved after 20 days of replacement therapy. This case report describes a pediatric patient who was promptly diagnosed with Wernicke’s encephalopathy, despite only 2 suspicious symptoms, and who completely recovered after high doses of thiamine were given intravenously.
| Original language | English |
|---|---|
| Pages (from-to) | 496-499 |
| Number of pages | 4 |
| Journal | Korean Journal of Pediatrics |
| Volume | 57 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2014 Nov 1 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Pediatrics
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Wernicke's encephalopathy in a child with high dose thiamine therapy. / Park, So Won; Yi, Yoon Young; Han, Jung Woo; Kim, Heung Dong; Lee, Joon Soo; Kang, Hoon Chul.
In: Korean Journal of Pediatrics, Vol. 57, No. 11, 01.11.2014, p. 496-499.Research output: Contribution to journal › Article
TY - JOUR
T1 - Wernicke's encephalopathy in a child with high dose thiamine therapy
AU - Park, So Won
AU - Yi, Yoon Young
AU - Han, Jung Woo
AU - Kim, Heung Dong
AU - Lee, Joon Soo
AU - Kang, Hoon Chul
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Wernicke’s encephalopathy is an acute neurological disorder characterized by mental confusion, oculomotor dysfunction, and ataxia. It has been reported in individuals with alcohol dependence, hyperemesis gravidarum, and prolonged parenteral nutrition without vitamin supplementation. Here we present the case of a 13-year-old male patient with neuroblastoma and a history of poor oral intake and nausea for 3 months. After admission, he showed gait disturbances, nystagmus, and excessive dizziness; his mental state, however, indicated he was alert, which did not fit the classical triad of Wernicke’s encephalopathy. A diagnosis of Wernicke’s encephalopathy was made only after brain magnetic resonance imaging and serum thiamine level analyses were performed. The patient’s symptoms remained after 5 days of treatment with 100-mg thiamine once daily; thus, we increased the dosage to 500 mg 3 times daily, 1,500 mg per day. His symptoms then improved after 20 days of replacement therapy. This case report describes a pediatric patient who was promptly diagnosed with Wernicke’s encephalopathy, despite only 2 suspicious symptoms, and who completely recovered after high doses of thiamine were given intravenously.
AB - Wernicke’s encephalopathy is an acute neurological disorder characterized by mental confusion, oculomotor dysfunction, and ataxia. It has been reported in individuals with alcohol dependence, hyperemesis gravidarum, and prolonged parenteral nutrition without vitamin supplementation. Here we present the case of a 13-year-old male patient with neuroblastoma and a history of poor oral intake and nausea for 3 months. After admission, he showed gait disturbances, nystagmus, and excessive dizziness; his mental state, however, indicated he was alert, which did not fit the classical triad of Wernicke’s encephalopathy. A diagnosis of Wernicke’s encephalopathy was made only after brain magnetic resonance imaging and serum thiamine level analyses were performed. The patient’s symptoms remained after 5 days of treatment with 100-mg thiamine once daily; thus, we increased the dosage to 500 mg 3 times daily, 1,500 mg per day. His symptoms then improved after 20 days of replacement therapy. This case report describes a pediatric patient who was promptly diagnosed with Wernicke’s encephalopathy, despite only 2 suspicious symptoms, and who completely recovered after high doses of thiamine were given intravenously.
UR - http://www.scopus.com/inward/record.url?scp=84951841131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951841131&partnerID=8YFLogxK
U2 - 10.3345/kjp.2014.57.11.496
DO - 10.3345/kjp.2014.57.11.496
M3 - Article
AN - SCOPUS:84951841131
VL - 57
SP - 496
EP - 499
JO - Korean Journal of Pediatrics
JF - Korean Journal of Pediatrics
SN - 1783-1061
IS - 11
ER -