What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography

Yuka Otaki; Reza Arsanjani; Heidi Gransar; Victor Y. Cheng; Damini Dey; Troy Labounty; Fay Y. Lin; Stephan Achenbach; Mouaz Al-Mallah; Matthew J. Budoff; Filippo Cademartiri; Tracy Q. Callister; Hyuk Jae Chang; Kavitha Chinnaiyan; Benjamin J.W. Chow; Augustin Delago; Martin Hadamitzky; Joerg Hausleiter; Philipp Kaufmann; Erica Maffei; Gilbert Raff; Leslee J. Shaw; Todd C. Villines; Allison Dunning; Ricardo C. Cury; Gudrun Feuchtner; Yong Jin Kim; Jonathon Leipsic; Daniel S. Berman; James K. Min

doi:10.1007/s12350-012-9582-1

What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography

Yuka Otaki, Reza Arsanjani, Heidi Gransar, Victor Y. Cheng, Damini Dey, Troy Labounty, Fay Y. Lin, Stephan Achenbach, Mouaz Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Hyuk Jae Chang, Kavitha Chinnaiyan, Benjamin J.W. Chow, Augustin Delago, Martin Hadamitzky, Joerg Hausleiter, Philipp Kaufmann, Erica MaffeiGilbert Raff, Leslee J. Shaw, Todd C. Villines, Allison Dunning, Ricardo C. Cury, Gudrun Feuchtner, Yong Jin Kim, Jonathon Leipsic, Daniel S. Berman, James K. Min

Department of Internal Medicine

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

Abstract

Coronary computed tomographic angiography (CCTA) employing CT scanners of 64-detector rows or greater represents a novel non-invasive method for detection of coronary artery disease (CAD), providing excellent diagnostic information when compared to invasive angiography. In addition to its high diagnostic performance, prior studies have shown that CCTA can provide important prognostic information, although these prior studies have been generally limited to small cohorts at single centers. The Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter registry, or CONFIRM, is a large, prospective, multinational, dynamic observational cohort study of patients undergoing CCTA. This registry currently represents more than 32,000 consecutive adults suspected of having CAD who underwent ≥64-detector row CCTA at 12 centers in 6 countries between 2005 and 2009. Based on its large sample size and adequate statistical power, the data derived from CONFIRM registry have and will continue to provide key answers to many important topics regarding CCTA. Based on its multisite international national design, the results derived from CONFIRM should be considered as more generalizable than prior smaller single-center studies. This article summarizes the current status of several studies from CONFIRM registry.

Original language	English
Pages (from-to)	787-795
Number of pages	9
Journal	Journal of Nuclear Cardiology
Volume	19
Issue number	4
DOIs	https://doi.org/10.1007/s12350-012-9582-1
Publication status	Published - 2012 Aug

Bibliographical note

Funding Information:
Dr Min received modest speakers’ bureau and medical advisory board compensation and significant research support from GE Healthcare. Dr Achenbach received grant support from Siemens and Bayer Schering Pharma and has served as a consultant for Servier. Dr Al-Mallah received support from the American Heart Association, BCBS Foundation of Michigan, and Astellas. Dr Cademartiri received grant support from GE Healthcare and has served on the Speakers’ Bureau of Bracco and as a consultant for Servier. Dr Maffei received grant support from GE Healthcare. Dr Chinnaiyan received grant support from Bayer Pharma and Blue Cross Blue Shield Blue Care MI. Dr Chow received research and fellowship support from GE Healthcare, research support from Pfizer and AstraZeneca, and educational support from TeraRecon. Dr Hausleiter received a research grant from Siemens Medical Systems. Dr Kaufmann received institutional research support from GE Healthcare and grant support from Swiss National Science Foundation. Dr Maffei received grant support from GE Healthcare. Dr Raff received grant support from Siemens, Blue Cross Blue Shield Blue Care MI, and Bayer Pharma. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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Otaki, Y., Arsanjani, R., Gransar, H., Cheng, V. Y., Dey, D., Labounty, T., Lin, F. Y., Achenbach, S., Al-Mallah, M., Budoff, M. J., Cademartiri, F., Callister, T. Q., Chang, H. J., Chinnaiyan, K., Chow, B. J. W., Delago, A., Hadamitzky, M., Hausleiter, J., Kaufmann, P., ... Min, J. K. (2012). What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography. Journal of Nuclear Cardiology, 19(4), 787-795. https://doi.org/10.1007/s12350-012-9582-1

@article{d564a91300ed43959dec597bd0d1821f,

title = "What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography",

abstract = "Coronary computed tomographic angiography (CCTA) employing CT scanners of 64-detector rows or greater represents a novel non-invasive method for detection of coronary artery disease (CAD), providing excellent diagnostic information when compared to invasive angiography. In addition to its high diagnostic performance, prior studies have shown that CCTA can provide important prognostic information, although these prior studies have been generally limited to small cohorts at single centers. The Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter registry, or CONFIRM, is a large, prospective, multinational, dynamic observational cohort study of patients undergoing CCTA. This registry currently represents more than 32,000 consecutive adults suspected of having CAD who underwent ≥64-detector row CCTA at 12 centers in 6 countries between 2005 and 2009. Based on its large sample size and adequate statistical power, the data derived from CONFIRM registry have and will continue to provide key answers to many important topics regarding CCTA. Based on its multisite international national design, the results derived from CONFIRM should be considered as more generalizable than prior smaller single-center studies. This article summarizes the current status of several studies from CONFIRM registry.",

author = "Yuka Otaki and Reza Arsanjani and Heidi Gransar and Cheng, {Victor Y.} and Damini Dey and Troy Labounty and Lin, {Fay Y.} and Stephan Achenbach and Mouaz Al-Mallah and Budoff, {Matthew J.} and Filippo Cademartiri and Callister, {Tracy Q.} and Chang, {Hyuk Jae} and Kavitha Chinnaiyan and Chow, {Benjamin J.W.} and Augustin Delago and Martin Hadamitzky and Joerg Hausleiter and Philipp Kaufmann and Erica Maffei and Gilbert Raff and Shaw, {Leslee J.} and Villines, {Todd C.} and Allison Dunning and Cury, {Ricardo C.} and Gudrun Feuchtner and Kim, {Yong Jin} and Jonathon Leipsic and Berman, {Daniel S.} and Min, {James K.}",

note = "Funding Information: Dr Min received modest speakers{\textquoteright} bureau and medical advisory board compensation and significant research support from GE Healthcare. Dr Achenbach received grant support from Siemens and Bayer Schering Pharma and has served as a consultant for Servier. Dr Al-Mallah received support from the American Heart Association, BCBS Foundation of Michigan, and Astellas. Dr Cademartiri received grant support from GE Healthcare and has served on the Speakers{\textquoteright} Bureau of Bracco and as a consultant for Servier. Dr Maffei received grant support from GE Healthcare. Dr Chinnaiyan received grant support from Bayer Pharma and Blue Cross Blue Shield Blue Care MI. Dr Chow received research and fellowship support from GE Healthcare, research support from Pfizer and AstraZeneca, and educational support from TeraRecon. Dr Hausleiter received a research grant from Siemens Medical Systems. Dr Kaufmann received institutional research support from GE Healthcare and grant support from Swiss National Science Foundation. Dr Maffei received grant support from GE Healthcare. Dr Raff received grant support from Siemens, Blue Cross Blue Shield Blue Care MI, and Bayer Pharma. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.",

year = "2012",

month = aug,

doi = "10.1007/s12350-012-9582-1",

language = "English",

volume = "19",

pages = "787--795",

journal = "Journal of Nuclear Cardiology",

issn = "1071-3581",

publisher = "Springer New York",

number = "4",

}

Otaki, Y, Arsanjani, R, Gransar, H, Cheng, VY, Dey, D, Labounty, T, Lin, FY, Achenbach, S, Al-Mallah, M, Budoff, MJ, Cademartiri, F, Callister, TQ, Chang, HJ, Chinnaiyan, K, Chow, BJW, Delago, A, Hadamitzky, M, Hausleiter, J, Kaufmann, P, Maffei, E, Raff, G, Shaw, LJ, Villines, TC, Dunning, A, Cury, RC, Feuchtner, G, Kim, YJ, Leipsic, J, Berman, DS & Min, JK 2012, 'What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography', Journal of Nuclear Cardiology, vol. 19, no. 4, pp. 787-795. https://doi.org/10.1007/s12350-012-9582-1

What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography. / Otaki, Yuka; Arsanjani, Reza; Gransar, Heidi et al.

In: Journal of Nuclear Cardiology, Vol. 19, No. 4, 08.2012, p. 787-795.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography

AU - Otaki, Yuka

AU - Arsanjani, Reza

AU - Gransar, Heidi

AU - Cheng, Victor Y.

AU - Dey, Damini

AU - Labounty, Troy

AU - Lin, Fay Y.

AU - Achenbach, Stephan

AU - Al-Mallah, Mouaz

AU - Budoff, Matthew J.

AU - Cademartiri, Filippo

AU - Callister, Tracy Q.

AU - Chang, Hyuk Jae

AU - Chinnaiyan, Kavitha

AU - Chow, Benjamin J.W.

AU - Delago, Augustin

AU - Hadamitzky, Martin

AU - Hausleiter, Joerg

AU - Kaufmann, Philipp

AU - Maffei, Erica

AU - Raff, Gilbert

AU - Shaw, Leslee J.

AU - Villines, Todd C.

AU - Dunning, Allison

AU - Cury, Ricardo C.

AU - Feuchtner, Gudrun

AU - Kim, Yong Jin

AU - Leipsic, Jonathon

AU - Berman, Daniel S.

AU - Min, James K.

N1 - Funding Information: Dr Min received modest speakers’ bureau and medical advisory board compensation and significant research support from GE Healthcare. Dr Achenbach received grant support from Siemens and Bayer Schering Pharma and has served as a consultant for Servier. Dr Al-Mallah received support from the American Heart Association, BCBS Foundation of Michigan, and Astellas. Dr Cademartiri received grant support from GE Healthcare and has served on the Speakers’ Bureau of Bracco and as a consultant for Servier. Dr Maffei received grant support from GE Healthcare. Dr Chinnaiyan received grant support from Bayer Pharma and Blue Cross Blue Shield Blue Care MI. Dr Chow received research and fellowship support from GE Healthcare, research support from Pfizer and AstraZeneca, and educational support from TeraRecon. Dr Hausleiter received a research grant from Siemens Medical Systems. Dr Kaufmann received institutional research support from GE Healthcare and grant support from Swiss National Science Foundation. Dr Maffei received grant support from GE Healthcare. Dr Raff received grant support from Siemens, Blue Cross Blue Shield Blue Care MI, and Bayer Pharma. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

PY - 2012/8

Y1 - 2012/8

N2 - Coronary computed tomographic angiography (CCTA) employing CT scanners of 64-detector rows or greater represents a novel non-invasive method for detection of coronary artery disease (CAD), providing excellent diagnostic information when compared to invasive angiography. In addition to its high diagnostic performance, prior studies have shown that CCTA can provide important prognostic information, although these prior studies have been generally limited to small cohorts at single centers. The Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter registry, or CONFIRM, is a large, prospective, multinational, dynamic observational cohort study of patients undergoing CCTA. This registry currently represents more than 32,000 consecutive adults suspected of having CAD who underwent ≥64-detector row CCTA at 12 centers in 6 countries between 2005 and 2009. Based on its large sample size and adequate statistical power, the data derived from CONFIRM registry have and will continue to provide key answers to many important topics regarding CCTA. Based on its multisite international national design, the results derived from CONFIRM should be considered as more generalizable than prior smaller single-center studies. This article summarizes the current status of several studies from CONFIRM registry.

AB - Coronary computed tomographic angiography (CCTA) employing CT scanners of 64-detector rows or greater represents a novel non-invasive method for detection of coronary artery disease (CAD), providing excellent diagnostic information when compared to invasive angiography. In addition to its high diagnostic performance, prior studies have shown that CCTA can provide important prognostic information, although these prior studies have been generally limited to small cohorts at single centers. The Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter registry, or CONFIRM, is a large, prospective, multinational, dynamic observational cohort study of patients undergoing CCTA. This registry currently represents more than 32,000 consecutive adults suspected of having CAD who underwent ≥64-detector row CCTA at 12 centers in 6 countries between 2005 and 2009. Based on its large sample size and adequate statistical power, the data derived from CONFIRM registry have and will continue to provide key answers to many important topics regarding CCTA. Based on its multisite international national design, the results derived from CONFIRM should be considered as more generalizable than prior smaller single-center studies. This article summarizes the current status of several studies from CONFIRM registry.

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SN - 1071-3581

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JO - Journal of Nuclear Cardiology

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ER -

What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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