What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography

Yuka Otaki, Reza Arsanjani, Heidi Gransar, Victor Y. Cheng, Damini Dey, Troy Labounty, Fay Y. Lin, Stephan Achenbach, Mouaz Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Hyuk Jae Chang, Kavitha Chinnaiyan, Benjamin J.W. Chow, Augustin Delago, Martin Hadamitzky, Joerg Hausleiter, Philipp Kaufmann, Erica MaffeiGilbert Raff, Leslee J. Shaw, Todd C. Villines, Allison Dunning, Ricardo C. Cury, Gudrun Feuchtner, Yong Jin Kim, Jonathon Leipsic, Daniel S. Berman, James K. Min

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Coronary computed tomographic angiography (CCTA) employing CT scanners of 64-detector rows or greater represents a novel non-invasive method for detection of coronary artery disease (CAD), providing excellent diagnostic information when compared to invasive angiography. In addition to its high diagnostic performance, prior studies have shown that CCTA can provide important prognostic information, although these prior studies have been generally limited to small cohorts at single centers. The Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter registry, or CONFIRM, is a large, prospective, multinational, dynamic observational cohort study of patients undergoing CCTA. This registry currently represents more than 32,000 consecutive adults suspected of having CAD who underwent ≥64-detector row CCTA at 12 centers in 6 countries between 2005 and 2009. Based on its large sample size and adequate statistical power, the data derived from CONFIRM registry have and will continue to provide key answers to many important topics regarding CCTA. Based on its multisite international national design, the results derived from CONFIRM should be considered as more generalizable than prior smaller single-center studies. This article summarizes the current status of several studies from CONFIRM registry.

Original languageEnglish
Pages (from-to)787-795
Number of pages9
JournalJournal of Nuclear Cardiology
Volume19
Issue number4
DOIs
Publication statusPublished - 2012 Aug 1

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Observational Studies
Angiography
Cohort Studies
Registries
Coronary Artery Disease
Coronary Angiography
Sample Size
Computed Tomography Angiography

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Otaki, Yuka ; Arsanjani, Reza ; Gransar, Heidi ; Cheng, Victor Y. ; Dey, Damini ; Labounty, Troy ; Lin, Fay Y. ; Achenbach, Stephan ; Al-Mallah, Mouaz ; Budoff, Matthew J. ; Cademartiri, Filippo ; Callister, Tracy Q. ; Chang, Hyuk Jae ; Chinnaiyan, Kavitha ; Chow, Benjamin J.W. ; Delago, Augustin ; Hadamitzky, Martin ; Hausleiter, Joerg ; Kaufmann, Philipp ; Maffei, Erica ; Raff, Gilbert ; Shaw, Leslee J. ; Villines, Todd C. ; Dunning, Allison ; Cury, Ricardo C. ; Feuchtner, Gudrun ; Kim, Yong Jin ; Leipsic, Jonathon ; Berman, Daniel S. ; Min, James K. / What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography. In: Journal of Nuclear Cardiology. 2012 ; Vol. 19, No. 4. pp. 787-795.
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abstract = "Coronary computed tomographic angiography (CCTA) employing CT scanners of 64-detector rows or greater represents a novel non-invasive method for detection of coronary artery disease (CAD), providing excellent diagnostic information when compared to invasive angiography. In addition to its high diagnostic performance, prior studies have shown that CCTA can provide important prognostic information, although these prior studies have been generally limited to small cohorts at single centers. The Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter registry, or CONFIRM, is a large, prospective, multinational, dynamic observational cohort study of patients undergoing CCTA. This registry currently represents more than 32,000 consecutive adults suspected of having CAD who underwent ≥64-detector row CCTA at 12 centers in 6 countries between 2005 and 2009. Based on its large sample size and adequate statistical power, the data derived from CONFIRM registry have and will continue to provide key answers to many important topics regarding CCTA. Based on its multisite international national design, the results derived from CONFIRM should be considered as more generalizable than prior smaller single-center studies. This article summarizes the current status of several studies from CONFIRM registry.",
author = "Yuka Otaki and Reza Arsanjani and Heidi Gransar and Cheng, {Victor Y.} and Damini Dey and Troy Labounty and Lin, {Fay Y.} and Stephan Achenbach and Mouaz Al-Mallah and Budoff, {Matthew J.} and Filippo Cademartiri and Callister, {Tracy Q.} and Chang, {Hyuk Jae} and Kavitha Chinnaiyan and Chow, {Benjamin J.W.} and Augustin Delago and Martin Hadamitzky and Joerg Hausleiter and Philipp Kaufmann and Erica Maffei and Gilbert Raff and Shaw, {Leslee J.} and Villines, {Todd C.} and Allison Dunning and Cury, {Ricardo C.} and Gudrun Feuchtner and Kim, {Yong Jin} and Jonathon Leipsic and Berman, {Daniel S.} and Min, {James K.}",
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Otaki, Y, Arsanjani, R, Gransar, H, Cheng, VY, Dey, D, Labounty, T, Lin, FY, Achenbach, S, Al-Mallah, M, Budoff, MJ, Cademartiri, F, Callister, TQ, Chang, HJ, Chinnaiyan, K, Chow, BJW, Delago, A, Hadamitzky, M, Hausleiter, J, Kaufmann, P, Maffei, E, Raff, G, Shaw, LJ, Villines, TC, Dunning, A, Cury, RC, Feuchtner, G, Kim, YJ, Leipsic, J, Berman, DS & Min, JK 2012, 'What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography', Journal of Nuclear Cardiology, vol. 19, no. 4, pp. 787-795. https://doi.org/10.1007/s12350-012-9582-1

What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography. / Otaki, Yuka; Arsanjani, Reza; Gransar, Heidi; Cheng, Victor Y.; Dey, Damini; Labounty, Troy; Lin, Fay Y.; Achenbach, Stephan; Al-Mallah, Mouaz; Budoff, Matthew J.; Cademartiri, Filippo; Callister, Tracy Q.; Chang, Hyuk Jae; Chinnaiyan, Kavitha; Chow, Benjamin J.W.; Delago, Augustin; Hadamitzky, Martin; Hausleiter, Joerg; Kaufmann, Philipp; Maffei, Erica; Raff, Gilbert; Shaw, Leslee J.; Villines, Todd C.; Dunning, Allison; Cury, Ricardo C.; Feuchtner, Gudrun; Kim, Yong Jin; Leipsic, Jonathon; Berman, Daniel S.; Min, James K.

In: Journal of Nuclear Cardiology, Vol. 19, No. 4, 01.08.2012, p. 787-795.

Research output: Contribution to journalReview article

TY - JOUR

T1 - What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography

AU - Otaki, Yuka

AU - Arsanjani, Reza

AU - Gransar, Heidi

AU - Cheng, Victor Y.

AU - Dey, Damini

AU - Labounty, Troy

AU - Lin, Fay Y.

AU - Achenbach, Stephan

AU - Al-Mallah, Mouaz

AU - Budoff, Matthew J.

AU - Cademartiri, Filippo

AU - Callister, Tracy Q.

AU - Chang, Hyuk Jae

AU - Chinnaiyan, Kavitha

AU - Chow, Benjamin J.W.

AU - Delago, Augustin

AU - Hadamitzky, Martin

AU - Hausleiter, Joerg

AU - Kaufmann, Philipp

AU - Maffei, Erica

AU - Raff, Gilbert

AU - Shaw, Leslee J.

AU - Villines, Todd C.

AU - Dunning, Allison

AU - Cury, Ricardo C.

AU - Feuchtner, Gudrun

AU - Kim, Yong Jin

AU - Leipsic, Jonathon

AU - Berman, Daniel S.

AU - Min, James K.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Coronary computed tomographic angiography (CCTA) employing CT scanners of 64-detector rows or greater represents a novel non-invasive method for detection of coronary artery disease (CAD), providing excellent diagnostic information when compared to invasive angiography. In addition to its high diagnostic performance, prior studies have shown that CCTA can provide important prognostic information, although these prior studies have been generally limited to small cohorts at single centers. The Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter registry, or CONFIRM, is a large, prospective, multinational, dynamic observational cohort study of patients undergoing CCTA. This registry currently represents more than 32,000 consecutive adults suspected of having CAD who underwent ≥64-detector row CCTA at 12 centers in 6 countries between 2005 and 2009. Based on its large sample size and adequate statistical power, the data derived from CONFIRM registry have and will continue to provide key answers to many important topics regarding CCTA. Based on its multisite international national design, the results derived from CONFIRM should be considered as more generalizable than prior smaller single-center studies. This article summarizes the current status of several studies from CONFIRM registry.

AB - Coronary computed tomographic angiography (CCTA) employing CT scanners of 64-detector rows or greater represents a novel non-invasive method for detection of coronary artery disease (CAD), providing excellent diagnostic information when compared to invasive angiography. In addition to its high diagnostic performance, prior studies have shown that CCTA can provide important prognostic information, although these prior studies have been generally limited to small cohorts at single centers. The Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter registry, or CONFIRM, is a large, prospective, multinational, dynamic observational cohort study of patients undergoing CCTA. This registry currently represents more than 32,000 consecutive adults suspected of having CAD who underwent ≥64-detector row CCTA at 12 centers in 6 countries between 2005 and 2009. Based on its large sample size and adequate statistical power, the data derived from CONFIRM registry have and will continue to provide key answers to many important topics regarding CCTA. Based on its multisite international national design, the results derived from CONFIRM should be considered as more generalizable than prior smaller single-center studies. This article summarizes the current status of several studies from CONFIRM registry.

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UR - http://www.scopus.com/inward/citedby.url?scp=84865086334&partnerID=8YFLogxK

U2 - 10.1007/s12350-012-9582-1

DO - 10.1007/s12350-012-9582-1

M3 - Review article

C2 - 22689072

AN - SCOPUS:84865086334

VL - 19

SP - 787

EP - 795

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 4

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