Which Factors Are Important for Successful Sentinel Node Navigation Surgery in Gastric Cancer Patients? Analysis from the SENORITA Prospective Multicenter Feasibility Quality Control Trial

Ji Yeong An, Jae Seok Min, Young Joon Lee, Sang Ho Jeong, Hoon Hur, Sang Uk Han, WooJin Hyung, Gyu Seok Cho, Gui Ae Jeong, Oh Jeong, Young Kyu Park, Mi Ran Jung, Ji Yeon Park, Young Woo Kim, Hong Man Yoon, Bang Wool Eom, Keun Won Ryu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background. We investigated the results of quality control study prior to phase III trial of sentinel lymph node navigation surgery (SNNS). Methods. Data were reviewed from 108 patients enrolled in the feasibility study of laparoscopic sentinel basin dissection (SBD) in gastric cancer. Seven steps contain tracer injection at submucosa (step 1) and at four sites (step 2) by intraoperative esophagogastroduodenoscopy (EGD), leakage of tracer (step 3), injection within 3 minutes (step 4), identification of at least one sentinel basin (SB) (step 5), evaluation of sentinel basin nodes (SBNs) by frozen biopsy (step 6), and identification of at least five SBNs at back table and frozen sections (step 7). Results. Failure in step 7 (n=23) was the most common followed by step 3 (n=15) and step 6 (n=13). We did not find any differences of clinicopathological factors between success and failure group in steps 16. In step 7, body mass index (BMI) was only the significant factor. The success rate was 97.1% in patients with BMI < 23 kg/m 2 and 80.3% in those with BMI ≥ 23 kg/m 2 (P=0.028). Conclusions. Lower BMI group showed higher success rate in step 7. Surgeons doing SNNS should be cautious when evaluating sufficient number of SBN in obese patients.

Original languageEnglish
Article number1732571
JournalGastroenterology Research and Practice
Volume2017
DOIs
Publication statusPublished - 2017 Jan 1

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Quality Control
Stomach Neoplasms
Body Mass Index
Digestive System Endoscopy
Injections
Frozen Sections
Feasibility Studies
Dissection
cyhalothrin
Biopsy
Sentinel Lymph Node

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

An, Ji Yeong ; Min, Jae Seok ; Lee, Young Joon ; Jeong, Sang Ho ; Hur, Hoon ; Han, Sang Uk ; Hyung, WooJin ; Cho, Gyu Seok ; Jeong, Gui Ae ; Jeong, Oh ; Park, Young Kyu ; Jung, Mi Ran ; Park, Ji Yeon ; Kim, Young Woo ; Yoon, Hong Man ; Eom, Bang Wool ; Ryu, Keun Won. / Which Factors Are Important for Successful Sentinel Node Navigation Surgery in Gastric Cancer Patients? Analysis from the SENORITA Prospective Multicenter Feasibility Quality Control Trial. In: Gastroenterology Research and Practice. 2017 ; Vol. 2017.
@article{76b5aa173918471a81cbea37f0a22677,
title = "Which Factors Are Important for Successful Sentinel Node Navigation Surgery in Gastric Cancer Patients? Analysis from the SENORITA Prospective Multicenter Feasibility Quality Control Trial",
abstract = "Background. We investigated the results of quality control study prior to phase III trial of sentinel lymph node navigation surgery (SNNS). Methods. Data were reviewed from 108 patients enrolled in the feasibility study of laparoscopic sentinel basin dissection (SBD) in gastric cancer. Seven steps contain tracer injection at submucosa (step 1) and at four sites (step 2) by intraoperative esophagogastroduodenoscopy (EGD), leakage of tracer (step 3), injection within 3 minutes (step 4), identification of at least one sentinel basin (SB) (step 5), evaluation of sentinel basin nodes (SBNs) by frozen biopsy (step 6), and identification of at least five SBNs at back table and frozen sections (step 7). Results. Failure in step 7 (n=23) was the most common followed by step 3 (n=15) and step 6 (n=13). We did not find any differences of clinicopathological factors between success and failure group in steps 16. In step 7, body mass index (BMI) was only the significant factor. The success rate was 97.1{\%} in patients with BMI < 23 kg/m 2 and 80.3{\%} in those with BMI ≥ 23 kg/m 2 (P=0.028). Conclusions. Lower BMI group showed higher success rate in step 7. Surgeons doing SNNS should be cautious when evaluating sufficient number of SBN in obese patients.",
author = "An, {Ji Yeong} and Min, {Jae Seok} and Lee, {Young Joon} and Jeong, {Sang Ho} and Hoon Hur and Han, {Sang Uk} and WooJin Hyung and Cho, {Gyu Seok} and Jeong, {Gui Ae} and Oh Jeong and Park, {Young Kyu} and Jung, {Mi Ran} and Park, {Ji Yeon} and Kim, {Young Woo} and Yoon, {Hong Man} and Eom, {Bang Wool} and Ryu, {Keun Won}",
year = "2017",
month = "1",
day = "1",
doi = "10.1155/2017/1732571",
language = "English",
volume = "2017",
journal = "Gastroenterology Research and Practice",
issn = "1687-6121",
publisher = "Hindawi Publishing Corporation",

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An, JY, Min, JS, Lee, YJ, Jeong, SH, Hur, H, Han, SU, Hyung, W, Cho, GS, Jeong, GA, Jeong, O, Park, YK, Jung, MR, Park, JY, Kim, YW, Yoon, HM, Eom, BW & Ryu, KW 2017, 'Which Factors Are Important for Successful Sentinel Node Navigation Surgery in Gastric Cancer Patients? Analysis from the SENORITA Prospective Multicenter Feasibility Quality Control Trial', Gastroenterology Research and Practice, vol. 2017, 1732571. https://doi.org/10.1155/2017/1732571

Which Factors Are Important for Successful Sentinel Node Navigation Surgery in Gastric Cancer Patients? Analysis from the SENORITA Prospective Multicenter Feasibility Quality Control Trial. / An, Ji Yeong; Min, Jae Seok; Lee, Young Joon; Jeong, Sang Ho; Hur, Hoon; Han, Sang Uk; Hyung, WooJin; Cho, Gyu Seok; Jeong, Gui Ae; Jeong, Oh; Park, Young Kyu; Jung, Mi Ran; Park, Ji Yeon; Kim, Young Woo; Yoon, Hong Man; Eom, Bang Wool; Ryu, Keun Won.

In: Gastroenterology Research and Practice, Vol. 2017, 1732571, 01.01.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Which Factors Are Important for Successful Sentinel Node Navigation Surgery in Gastric Cancer Patients? Analysis from the SENORITA Prospective Multicenter Feasibility Quality Control Trial

AU - An, Ji Yeong

AU - Min, Jae Seok

AU - Lee, Young Joon

AU - Jeong, Sang Ho

AU - Hur, Hoon

AU - Han, Sang Uk

AU - Hyung, WooJin

AU - Cho, Gyu Seok

AU - Jeong, Gui Ae

AU - Jeong, Oh

AU - Park, Young Kyu

AU - Jung, Mi Ran

AU - Park, Ji Yeon

AU - Kim, Young Woo

AU - Yoon, Hong Man

AU - Eom, Bang Wool

AU - Ryu, Keun Won

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background. We investigated the results of quality control study prior to phase III trial of sentinel lymph node navigation surgery (SNNS). Methods. Data were reviewed from 108 patients enrolled in the feasibility study of laparoscopic sentinel basin dissection (SBD) in gastric cancer. Seven steps contain tracer injection at submucosa (step 1) and at four sites (step 2) by intraoperative esophagogastroduodenoscopy (EGD), leakage of tracer (step 3), injection within 3 minutes (step 4), identification of at least one sentinel basin (SB) (step 5), evaluation of sentinel basin nodes (SBNs) by frozen biopsy (step 6), and identification of at least five SBNs at back table and frozen sections (step 7). Results. Failure in step 7 (n=23) was the most common followed by step 3 (n=15) and step 6 (n=13). We did not find any differences of clinicopathological factors between success and failure group in steps 16. In step 7, body mass index (BMI) was only the significant factor. The success rate was 97.1% in patients with BMI < 23 kg/m 2 and 80.3% in those with BMI ≥ 23 kg/m 2 (P=0.028). Conclusions. Lower BMI group showed higher success rate in step 7. Surgeons doing SNNS should be cautious when evaluating sufficient number of SBN in obese patients.

AB - Background. We investigated the results of quality control study prior to phase III trial of sentinel lymph node navigation surgery (SNNS). Methods. Data were reviewed from 108 patients enrolled in the feasibility study of laparoscopic sentinel basin dissection (SBD) in gastric cancer. Seven steps contain tracer injection at submucosa (step 1) and at four sites (step 2) by intraoperative esophagogastroduodenoscopy (EGD), leakage of tracer (step 3), injection within 3 minutes (step 4), identification of at least one sentinel basin (SB) (step 5), evaluation of sentinel basin nodes (SBNs) by frozen biopsy (step 6), and identification of at least five SBNs at back table and frozen sections (step 7). Results. Failure in step 7 (n=23) was the most common followed by step 3 (n=15) and step 6 (n=13). We did not find any differences of clinicopathological factors between success and failure group in steps 16. In step 7, body mass index (BMI) was only the significant factor. The success rate was 97.1% in patients with BMI < 23 kg/m 2 and 80.3% in those with BMI ≥ 23 kg/m 2 (P=0.028). Conclusions. Lower BMI group showed higher success rate in step 7. Surgeons doing SNNS should be cautious when evaluating sufficient number of SBN in obese patients.

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DO - 10.1155/2017/1732571

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