Background: Hypertension and diabetes mellitus (DM) are major risk factors for the cardiovascular disease. In this retrospective cohort study, we compared the long-term clinical outcomes between antecedent hypertension and DM in acute myocardial infarction (AMI) patients after stent implantation. Methods: A total of 32 938 eligible AMI patients were enrolled and divided into the four groups according to the presence or absence of hypertension and DM (hypertension −/DM −[group A, 13 773 patients], hypertension +/DM −[group B, 10 395 patients], hypertension −/DM + [group C, 3050 patients], and hypertension +/DM + [group D, 5720 patients]). The clinical endpoint was the cumulative incidence of major adverse cardiac events (MACEs) defined as all-cause death, recurrent myocardial infarction (Re-MI) and any repeat revascularization during the 2-year follow-up period. Results: After adjustment, the cumulative incidence of MACEs (adjusted hazard ratio [aHR], 1.232; 95% confidence interval [CI], 0.982-1.567; P =.071), all-cause death, and e-MI Re-MI were similar between the group B and C. However, the cumulative incidences of any repeat revascularization (aHR, 1.438; 95% CI, 1.062-1.997; P =.007), target lesion revascularization (TLR) (aHR, 2.467; 95% CI, 1.552-3.922; P <.001), and target vessel revascularization (TVR) (aHR, 1.671; 95% CI, 1.256-2.222; P <.001) were significantly higher in group C compared with group B. Conclusions: This large number of a nonrandomized and multicenter cohort study clearly demonstrated the detrimental impacts of the hypertension and diabetes on long-term clinical outcomes. Moreover, higher incidence of repeat revascularization after PCI in diabetic AMI patients a major concern until recently.
|Translated title of the contribution||Which is the worst risk factor for the long-term clinical outcome? Comparison of long-term clinical outcomes between antecedent hypertension and diabetes mellitus in South Korean acute myocardial infarction patients after stent implantation|
|Original language||Chinese (Traditional)|
|Number of pages||15|
|Journal||Journal of diabetes|
|Publication status||Published - 2020 Feb 1|
Bibliographical noteFunding Information:
This research was supported by a fund (2016-ER6304-02) by Research of Korea Centers for Disease Control and Prevention. We would like to acknowledge Dr. Malcom Neil Allison (firstname.lastname@example.org) for editorial assistance. The authors thank all of the clinical investigators who contributed time and effort to this study, as well as the Korea Acute Myocardial Infarction (KAMIR) Investigators.
All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism