Whole grain cereal attenuates obesity-induced muscle atrophy by activating the PI3K/Akt pathway in obese C57BL/6N mice

Sein Lee, Mi Bo Kim, Changhee Kim, Jae Kwan Hwang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Whole grain comprises starchy endosperm, germ, and bran tissues, which contain fibers, minerals, vitamins, and several phytochemicals. Whole grain cereal (WGC)-based food products supply beneficial nutrients (essential for health care) and macronutrients (essential for body maintenance and support). The present study investigated the inhibitory effect of WGC on obesity-induced muscle atrophy in obese C57BL/6N mice. WGC attenuated the body weight gain, fat pad mass, adipocyte size, food efficiency ratio, serum lipid profile, and non-alcoholic fatty liver. Furthermore, WGC increased muscle mass and muscle strength by activating the phosphatidylinositol 3-kinase/protein kinase B pathway. Accordingly, WGC up-regulated the expression of factors that regulate muscle hypertrophy and myogenesis, whereas it down-regulated the atrophy-related factors. Overall, these results demonstrate that WGC effectively attenuates obesity-induced muscle atrophy as well as overall obesity, suggesting that WGC can be used as a functional food.

Original languageEnglish
Pages (from-to)159-168
Number of pages10
JournalFood Science and Biotechnology
Volume27
Issue number1
DOIs
Publication statusPublished - 2018 Feb 1

Fingerprint

Obese Mice
muscular atrophy
Muscular Atrophy
whole grain foods
phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases
Inbred C57BL Mouse
small cereal grains
obesity
Obesity
mice
Mineral Fibers
Phosphatidylinositol 3-Kinase
synthetic fibers
muscle strength
Food
Muscles
muscles
Proto-Oncogene Proteins c-akt
Endosperm

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

Cite this

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title = "Whole grain cereal attenuates obesity-induced muscle atrophy by activating the PI3K/Akt pathway in obese C57BL/6N mice",
abstract = "Whole grain comprises starchy endosperm, germ, and bran tissues, which contain fibers, minerals, vitamins, and several phytochemicals. Whole grain cereal (WGC)-based food products supply beneficial nutrients (essential for health care) and macronutrients (essential for body maintenance and support). The present study investigated the inhibitory effect of WGC on obesity-induced muscle atrophy in obese C57BL/6N mice. WGC attenuated the body weight gain, fat pad mass, adipocyte size, food efficiency ratio, serum lipid profile, and non-alcoholic fatty liver. Furthermore, WGC increased muscle mass and muscle strength by activating the phosphatidylinositol 3-kinase/protein kinase B pathway. Accordingly, WGC up-regulated the expression of factors that regulate muscle hypertrophy and myogenesis, whereas it down-regulated the atrophy-related factors. Overall, these results demonstrate that WGC effectively attenuates obesity-induced muscle atrophy as well as overall obesity, suggesting that WGC can be used as a functional food.",
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Whole grain cereal attenuates obesity-induced muscle atrophy by activating the PI3K/Akt pathway in obese C57BL/6N mice. / Lee, Sein; Kim, Mi Bo; Kim, Changhee; Hwang, Jae Kwan.

In: Food Science and Biotechnology, Vol. 27, No. 1, 01.02.2018, p. 159-168.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Whole grain cereal attenuates obesity-induced muscle atrophy by activating the PI3K/Akt pathway in obese C57BL/6N mice

AU - Lee, Sein

AU - Kim, Mi Bo

AU - Kim, Changhee

AU - Hwang, Jae Kwan

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