Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea

Kyungwon Lee, Mi Na Kim, Tae Yeal Choi, Soung Eun Cho, Seungok Lee, Dong Hee Whang, Dongeun Yong, Yunsop Chong, Neil Woodford, David M. Livermore

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-β-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.

Original languageEnglish
Pages (from-to)520-524
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume33
Issue number6
DOIs
Publication statusPublished - 2009 Jun 1

Fingerprint

Acinetobacter baumannii
Republic of Korea
Acinetobacter
Acinetobacter calcoaceticus
Genes
Carbapenems
Imipenem
Pulsed Field Gel Electrophoresis
Clone Cells
Asp(5)-oxytocin

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Lee, Kyungwon ; Kim, Mi Na ; Choi, Tae Yeal ; Cho, Soung Eun ; Lee, Seungok ; Whang, Dong Hee ; Yong, Dongeun ; Chong, Yunsop ; Woodford, Neil ; Livermore, David M. / Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea. In: International Journal of Antimicrobial Agents. 2009 ; Vol. 33, No. 6. pp. 520-524.
@article{3daccfff1a764939b92848015ae7e0a0,
title = "Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea",
abstract = "Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-β-lactamases were detected in only 19.4{\%} of isolates, none of which were Acinetobacter baumannii, whereas 74.3{\%} of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.",
author = "Kyungwon Lee and Kim, {Mi Na} and Choi, {Tae Yeal} and Cho, {Soung Eun} and Seungok Lee and Whang, {Dong Hee} and Dongeun Yong and Yunsop Chong and Neil Woodford and Livermore, {David M.}",
year = "2009",
month = "6",
day = "1",
doi = "10.1016/j.ijantimicag.2008.10.009",
language = "English",
volume = "33",
pages = "520--524",
journal = "International Journal of Antimicrobial Agents",
issn = "0924-8579",
publisher = "Elsevier",
number = "6",

}

Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea. / Lee, Kyungwon; Kim, Mi Na; Choi, Tae Yeal; Cho, Soung Eun; Lee, Seungok; Whang, Dong Hee; Yong, Dongeun; Chong, Yunsop; Woodford, Neil; Livermore, David M.

In: International Journal of Antimicrobial Agents, Vol. 33, No. 6, 01.06.2009, p. 520-524.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea

AU - Lee, Kyungwon

AU - Kim, Mi Na

AU - Choi, Tae Yeal

AU - Cho, Soung Eun

AU - Lee, Seungok

AU - Whang, Dong Hee

AU - Yong, Dongeun

AU - Chong, Yunsop

AU - Woodford, Neil

AU - Livermore, David M.

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-β-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.

AB - Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-β-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.

UR - http://www.scopus.com/inward/record.url?scp=64549155641&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64549155641&partnerID=8YFLogxK

U2 - 10.1016/j.ijantimicag.2008.10.009

DO - 10.1016/j.ijantimicag.2008.10.009

M3 - Article

C2 - 19091520

AN - SCOPUS:64549155641

VL - 33

SP - 520

EP - 524

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

SN - 0924-8579

IS - 6

ER -