Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea

Kyungwon Lee, Mi Na Kim, Tae Yeal Choi, Soung Eun Cho, Seungok Lee, Dong Hee Whang, Dongeun Yong, Yunsop Chong, Neil Woodford, David M. Livermore

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-β-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.

Original languageEnglish
Pages (from-to)520-524
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume33
Issue number6
DOIs
Publication statusPublished - 2009 Jun 1

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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