Herein, a wireless and soft smart contact lens that enables real-time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol-related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non-invasive healthcare device.
|Publication status||Published - 2022 Oct 5|
Bibliographical noteFunding Information:
This work was supported by the Ministry of Science & ICT (MSIT), the Ministry of Trade, Industry and Energy (MOTIE), the Ministry of Health & Welfare, and the Ministry of Food and Drug Safety of Korea through the National Research Foundation for Nano Material Technology Development Program (2021M3D1A204991411), the Bio & Medical Technology Development Program (2018M3A9F1021649), the Wearable Platform Materials Technology Center ERC Program (2022R1A5A6000846), the Korea Initiative for fostering University of Research and Innovation (KIURI) Program (2020M3H1A1077207), the Technology Innovation Program (20013621, Center for Super Critical Material Industrial Technology), and the Korea Medical Device Development Fund grant (RMS 2022‐11‐1209 / KMDF RS‐2022‐00141392). In addition, the authors are thankful for the financial support by the Samsung Research Funding & Incubation Center of Samsung Electronics (SRFC‐TC2003‐03) and the Institute for Basic Science (IBS‐R026‐D1).
© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Chemical Engineering(all)
- Materials Science(all)
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Physics and Astronomy(all)