Wireless Non-Invasive Monitoring of Cholesterol Using a Smart Contact Lens

Hayoung Song; Haein Shin; Hunkyu Seo; Wonjung Park; Byung Jun Joo; Jeongho Kim; Jeonghyun Kim; Hong Kyun Kim; Jayoung Kim; Jang Ung Park

doi:10.1002/advs.202203597

Wireless Non-Invasive Monitoring of Cholesterol Using a Smart Contact Lens

Hayoung Song, Haein Shin, Hunkyu Seo, Wonjung Park, Byung Jun Joo, Jeongho Kim, Jeonghyun Kim, Hong Kyun Kim, Jayoung Kim, Jang Ung Park

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Herein, a wireless and soft smart contact lens that enables real-time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol-related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non-invasive healthcare device.

Original language	English
Article number	2203597
Journal	Advanced Science
Volume	9
Issue number	28
DOIs	https://doi.org/10.1002/advs.202203597
Publication status	Published - 2022 Oct 5

Bibliographical note

Funding Information:
This work was supported by the Ministry of Science & ICT (MSIT), the Ministry of Trade, Industry and Energy (MOTIE), the Ministry of Health & Welfare, and the Ministry of Food and Drug Safety of Korea through the National Research Foundation for Nano Material Technology Development Program (2021M3D1A204991411), the Bio & Medical Technology Development Program (2018M3A9F1021649), the Wearable Platform Materials Technology Center ERC Program (2022R1A5A6000846), the Korea Initiative for fostering University of Research and Innovation (KIURI) Program (2020M3H1A1077207), the Technology Innovation Program (20013621, Center for Super Critical Material Industrial Technology), and the Korea Medical Device Development Fund grant (RMS 2022‐11‐1209 / KMDF RS‐2022‐00141392). In addition, the authors are thankful for the financial support by the Samsung Research Funding & Incubation Center of Samsung Electronics (SRFC‐TC2003‐03) and the Institute for Basic Science (IBS‐R026‐D1).

Publisher Copyright:
© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Chemical Engineering(all)
Materials Science(all)
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Engineering(all)
Physics and Astronomy(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/advs.202203597

Cite this

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title = "Wireless Non-Invasive Monitoring of Cholesterol Using a Smart Contact Lens",

abstract = "Herein, a wireless and soft smart contact lens that enables real-time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol-related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non-invasive healthcare device.",

author = "Hayoung Song and Haein Shin and Hunkyu Seo and Wonjung Park and Joo, {Byung Jun} and Jeongho Kim and Jeonghyun Kim and Kim, {Hong Kyun} and Jayoung Kim and Park, {Jang Ung}",

note = "Funding Information: This work was supported by the Ministry of Science & ICT (MSIT), the Ministry of Trade, Industry and Energy (MOTIE), the Ministry of Health & Welfare, and the Ministry of Food and Drug Safety of Korea through the National Research Foundation for Nano Material Technology Development Program (2021M3D1A204991411), the Bio & Medical Technology Development Program (2018M3A9F1021649), the Wearable Platform Materials Technology Center ERC Program (2022R1A5A6000846), the Korea Initiative for fostering University of Research and Innovation (KIURI) Program (2020M3H1A1077207), the Technology Innovation Program (20013621, Center for Super Critical Material Industrial Technology), and the Korea Medical Device Development Fund grant (RMS 2022‐11‐1209 / KMDF RS‐2022‐00141392). In addition, the authors are thankful for the financial support by the Samsung Research Funding & Incubation Center of Samsung Electronics (SRFC‐TC2003‐03) and the Institute for Basic Science (IBS‐R026‐D1). Publisher Copyright: {\textcopyright} 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.",

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AU - Kim, Jeonghyun

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AU - Kim, Jayoung

AU - Park, Jang Ung

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AB - Herein, a wireless and soft smart contact lens that enables real-time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol-related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non-invasive healthcare device.

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Wireless Non-Invasive Monitoring of Cholesterol Using a Smart Contact Lens

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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