Wisteria floribunda agglutinin-positive human Mac-2 binding protein predicts the risk of HBV-related liver cancer development

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Abstract

Background & Aims: Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA+-M2BP) can be used to assess the degree of liver fibrosis, but few studies have investigated its prognostic utility. We evaluated whether serum WFA+-M2BP can predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. Methods: A total of 1323 CHB patients with WFA+-M2BP test results between 2009 and 2011 were included in this retrospective analysis. Results: The mean age of patients (793 men) was 51.0 years. During the follow-up period (median 60.3 months), 52 (3.9%) patients developed HCC. Age, the proportion of male gender, the presence of diabetes and cirrhosis, and levels of aspartate aminotransferase, alpha-foetoprotein, and WFA+-M2BP were significantly greater in patients with HCC than in those without HCC, whereas serum albumin levels and platelet counts were significantly lower in patients with HCC than in those without HCC (all P<.05). In multivariate analysis, WFA+-M2BP level was an independent predictor of HCC development (adjusted hazard ratio 1.143, 95% CI: 1.139-1.829), along with male gender and diabetes (all P<.05). In patients without cirrhosis (n=1087), WFA+-M2BP levels ≥1.8 were associated with a higher risk of HCC development (P<.001 by log-rank test), whereas WFA+-M2BP levels ≥1.8 tended to be associated with a higher risk of HCC development in patients with cirrhosis (n=236) (P=.073 by log-rank test). Conclusions: WFA+-M2BP level can independently predict HCC development. Further studies should investigate whether WFA+-M2BP level could be incorporated into surveillance strategies for CHB patients.

Original languageEnglish
Pages (from-to)879-887
Number of pages9
JournalLiver International
Volume37
Issue number6
DOIs
Publication statusPublished - 2017 Jun

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Liver Neoplasms
Hepatocellular Carcinoma
Chronic Hepatitis B
Fibrosis
human TAA90K protein
wisteria lectin
alpha-Fetoproteins
Aspartate Aminotransferases
Platelet Count
Serum Albumin
Liver Cirrhosis
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

@article{5aeadc4339024c5db147a5bf6d70e497,
title = "Wisteria floribunda agglutinin-positive human Mac-2 binding protein predicts the risk of HBV-related liver cancer development",
abstract = "Background & Aims: Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA+-M2BP) can be used to assess the degree of liver fibrosis, but few studies have investigated its prognostic utility. We evaluated whether serum WFA+-M2BP can predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. Methods: A total of 1323 CHB patients with WFA+-M2BP test results between 2009 and 2011 were included in this retrospective analysis. Results: The mean age of patients (793 men) was 51.0 years. During the follow-up period (median 60.3 months), 52 (3.9{\%}) patients developed HCC. Age, the proportion of male gender, the presence of diabetes and cirrhosis, and levels of aspartate aminotransferase, alpha-foetoprotein, and WFA+-M2BP were significantly greater in patients with HCC than in those without HCC, whereas serum albumin levels and platelet counts were significantly lower in patients with HCC than in those without HCC (all P<.05). In multivariate analysis, WFA+-M2BP level was an independent predictor of HCC development (adjusted hazard ratio 1.143, 95{\%} CI: 1.139-1.829), along with male gender and diabetes (all P<.05). In patients without cirrhosis (n=1087), WFA+-M2BP levels ≥1.8 were associated with a higher risk of HCC development (P<.001 by log-rank test), whereas WFA+-M2BP levels ≥1.8 tended to be associated with a higher risk of HCC development in patients with cirrhosis (n=236) (P=.073 by log-rank test). Conclusions: WFA+-M2BP level can independently predict HCC development. Further studies should investigate whether WFA+-M2BP level could be incorporated into surveillance strategies for CHB patients.",
author = "Kim, {Seung Up} and Heo, {Ja Yoon} and Kim, {Beom Kyung} and Park, {Jun Yong} and Kim, {Do Young} and Han, {Kwang Hyub} and Ahn, {Sang Hoon} and Kim, {Hyon Suk}",
year = "2017",
month = "6",
doi = "10.1111/liv.13341",
language = "English",
volume = "37",
pages = "879--887",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
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TY - JOUR

T1 - Wisteria floribunda agglutinin-positive human Mac-2 binding protein predicts the risk of HBV-related liver cancer development

AU - Kim, Seung Up

AU - Heo, Ja Yoon

AU - Kim, Beom Kyung

AU - Park, Jun Yong

AU - Kim, Do Young

AU - Han, Kwang Hyub

AU - Ahn, Sang Hoon

AU - Kim, Hyon Suk

PY - 2017/6

Y1 - 2017/6

N2 - Background & Aims: Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA+-M2BP) can be used to assess the degree of liver fibrosis, but few studies have investigated its prognostic utility. We evaluated whether serum WFA+-M2BP can predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. Methods: A total of 1323 CHB patients with WFA+-M2BP test results between 2009 and 2011 were included in this retrospective analysis. Results: The mean age of patients (793 men) was 51.0 years. During the follow-up period (median 60.3 months), 52 (3.9%) patients developed HCC. Age, the proportion of male gender, the presence of diabetes and cirrhosis, and levels of aspartate aminotransferase, alpha-foetoprotein, and WFA+-M2BP were significantly greater in patients with HCC than in those without HCC, whereas serum albumin levels and platelet counts were significantly lower in patients with HCC than in those without HCC (all P<.05). In multivariate analysis, WFA+-M2BP level was an independent predictor of HCC development (adjusted hazard ratio 1.143, 95% CI: 1.139-1.829), along with male gender and diabetes (all P<.05). In patients without cirrhosis (n=1087), WFA+-M2BP levels ≥1.8 were associated with a higher risk of HCC development (P<.001 by log-rank test), whereas WFA+-M2BP levels ≥1.8 tended to be associated with a higher risk of HCC development in patients with cirrhosis (n=236) (P=.073 by log-rank test). Conclusions: WFA+-M2BP level can independently predict HCC development. Further studies should investigate whether WFA+-M2BP level could be incorporated into surveillance strategies for CHB patients.

AB - Background & Aims: Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA+-M2BP) can be used to assess the degree of liver fibrosis, but few studies have investigated its prognostic utility. We evaluated whether serum WFA+-M2BP can predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. Methods: A total of 1323 CHB patients with WFA+-M2BP test results between 2009 and 2011 were included in this retrospective analysis. Results: The mean age of patients (793 men) was 51.0 years. During the follow-up period (median 60.3 months), 52 (3.9%) patients developed HCC. Age, the proportion of male gender, the presence of diabetes and cirrhosis, and levels of aspartate aminotransferase, alpha-foetoprotein, and WFA+-M2BP were significantly greater in patients with HCC than in those without HCC, whereas serum albumin levels and platelet counts were significantly lower in patients with HCC than in those without HCC (all P<.05). In multivariate analysis, WFA+-M2BP level was an independent predictor of HCC development (adjusted hazard ratio 1.143, 95% CI: 1.139-1.829), along with male gender and diabetes (all P<.05). In patients without cirrhosis (n=1087), WFA+-M2BP levels ≥1.8 were associated with a higher risk of HCC development (P<.001 by log-rank test), whereas WFA+-M2BP levels ≥1.8 tended to be associated with a higher risk of HCC development in patients with cirrhosis (n=236) (P=.073 by log-rank test). Conclusions: WFA+-M2BP level can independently predict HCC development. Further studies should investigate whether WFA+-M2BP level could be incorporated into surveillance strategies for CHB patients.

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U2 - 10.1111/liv.13341

DO - 10.1111/liv.13341

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C2 - 27973711

AN - SCOPUS:85007413352

VL - 37

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JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 6

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