WNKs: Protein kinases with a unique kinase domain

Chou Long Huang, Seungkuy Cha, Hao Ran Wang, Jian Xie, Melanie H. Cobb

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in regulating ion transport were first revealed by the findings that mutations of two members cause a genetic hypertension and hyperkalemia syndrome. More recent studies suggest that WNKs are pleiotropic protein kinases with important roles in many cell processes in addition to ion transport. Here, we review roles of WNK kinases in the regulation of ion balance, cell signaling, survival, and proliferation, and embryonic organ development.

Original languageEnglish
Pages (from-to)565-573
Number of pages9
JournalExperimental and Molecular Medicine
Volume39
Issue number5
DOIs
Publication statusPublished - 2007 Oct 31

Fingerprint

Ion Transport
Protein Kinases
Lysine
Phosphotransferases
Ions
Hyperkalemia
Protein-Serine-Threonine Kinases
Cell signaling
Embryonic Development
Cell Survival
Cell Proliferation
Cell proliferation
Hypertension
Mutation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Huang, Chou Long ; Cha, Seungkuy ; Wang, Hao Ran ; Xie, Jian ; Cobb, Melanie H. / WNKs : Protein kinases with a unique kinase domain. In: Experimental and Molecular Medicine. 2007 ; Vol. 39, No. 5. pp. 565-573.
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WNKs : Protein kinases with a unique kinase domain. / Huang, Chou Long; Cha, Seungkuy; Wang, Hao Ran; Xie, Jian; Cobb, Melanie H.

In: Experimental and Molecular Medicine, Vol. 39, No. 5, 31.10.2007, p. 565-573.

Research output: Contribution to journalReview article

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T2 - Protein kinases with a unique kinase domain

AU - Huang, Chou Long

AU - Cha, Seungkuy

AU - Wang, Hao Ran

AU - Xie, Jian

AU - Cobb, Melanie H.

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