WNKs: Protein kinases with a unique kinase domain

Chou Long Huang, Seung Kuy Cha, Hao Ran Wang, Jian Xie, Melanie H. Cobb

Research output: Contribution to journalReview articlepeer-review

41 Citations (Scopus)


WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in regulating ion transport were first revealed by the findings that mutations of two members cause a genetic hypertension and hyperkalemia syndrome. More recent studies suggest that WNKs are pleiotropic protein kinases with important roles in many cell processes in addition to ion transport. Here, we review roles of WNK kinases in the regulation of ion balance, cell signaling, survival, and proliferation, and embryonic organ development.

Original languageEnglish
Pages (from-to)565-573
Number of pages9
JournalExperimental and Molecular Medicine
Issue number5
Publication statusPublished - 2007 Oct 31

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry


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