TY - JOUR
T1 - Wnt Pathway in Bone Repair and Regeneration – What Do We Know So Far
AU - Houschyar, Khosrow S.
AU - Tapking, Christian
AU - Borrelli, Mimi R.
AU - Popp, Daniel
AU - Duscher, Dominik
AU - Maan, Zeshaan N.
AU - Chelliah, Malcolm P.
AU - Li, Jingtao
AU - Harati, Kamran
AU - Wallner, Christoph
AU - Rein, Susanne
AU - Pförringer, Dominik
AU - Reumuth, Georg
AU - Grieb, Gerrit
AU - Mouraret, Sylvain
AU - Dadras, Mehran
AU - Wagner, Johannes M.
AU - Cha, Jungul Y.
AU - Siemers, Frank
AU - Lehnhardt, Marcus
AU - Behr, Björn
N1 - Funding Information:
We acknowledge support by the DFG Open Access Publication Funds of the Ruhr-Universität Bochum.
Publisher Copyright:
© Copyright © 2019 Houschyar, Tapking, Borrelli, Popp, Duscher, Maan, Chelliah, Li, Harati, Wallner, Rein, Pförringer, Reumuth, Grieb, Mouraret, Dadras, Wagner, Cha, Siemers, Lehnhardt and Behr.
PY - 2019/1/7
Y1 - 2019/1/7
N2 - Wnt signaling plays a central regulatory role across a remarkably diverse range of functions during embryonic development, including those involved in the formation of bone and cartilage. Wnt signaling continues to play a critical role in adult osteogenic differentiation of mesenchymal stem cells. Disruptions in this highly-conserved and complex system leads to various pathological conditions, including impaired bone healing, autoimmune diseases and malignant degeneration. For reconstructive surgeons, critically sized skeletal defects represent a major challenge. These are frequently associated with significant morbidity in both the recipient and donor sites. The Wnt pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for skeletal tissue regeneration and promote bone growth, suggesting that Wnt factors could be used to promote bone healing after trauma. This review summarizes our current understanding of the essential role of the Wnt pathway in bone regeneration and repair.
AB - Wnt signaling plays a central regulatory role across a remarkably diverse range of functions during embryonic development, including those involved in the formation of bone and cartilage. Wnt signaling continues to play a critical role in adult osteogenic differentiation of mesenchymal stem cells. Disruptions in this highly-conserved and complex system leads to various pathological conditions, including impaired bone healing, autoimmune diseases and malignant degeneration. For reconstructive surgeons, critically sized skeletal defects represent a major challenge. These are frequently associated with significant morbidity in both the recipient and donor sites. The Wnt pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for skeletal tissue regeneration and promote bone growth, suggesting that Wnt factors could be used to promote bone healing after trauma. This review summarizes our current understanding of the essential role of the Wnt pathway in bone regeneration and repair.
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U2 - 10.3389/fcell.2018.00170
DO - 10.3389/fcell.2018.00170
M3 - Review article
AN - SCOPUS:85096443561
VL - 6
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
SN - 2296-634X
M1 - 170
ER -